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Glutathione metabolism
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Ebook "Sulfur assimilation and abiotic stress in plants" discusses the aspects of sustainable crop production with sulfur, the importance of sulfur metabolites and sulfur metabolizing enzymes in abiotic stress management in plants. Sulfur is one of the four major essential elements necessary for the plant life cycle. Its assimilation in higher plants and its reduction in metabolically important sulfur compounds are crucial factors determining plant growth and vigor and resistance to stresses.
373p
tachieuhoa
28-01-2024
3
2
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Ebook "Abiotic stress responses in plants: Metabolism, productivity and sustainability" deals with abiotic stress-induced morphological and anatomical changes, abberations in metabolism, strategies and approaches to increase salt tolerance, managing the drought stress, sustainable fruit production and postharvest stress treatments, role of glutathione reductase, flavonoids as antioxidants in plants, the role of salicylic acid and trehalose in plants, stress-induced flowering.
475p
tachieuhoa
28-01-2024
9
2
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Ebook "Gamma-glutamyl transpeptidases: Structure and function" covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine. Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine.
65p
lucchinguyen
28-12-2023
4
2
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This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. We sought to understand the connection between the exosomal Medium-chain acyl-CoA dehydrogenase (ACADM) level and the reaction to gemcitabine in vivo and in patients with PC.
14p
vioracle
29-09-2023
5
2
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In this study, we determined the in vitro inhibitory effects of metal ions such as Cu2+, Cd2+, Ag+, and Co2+ on GST enzyme activity. For this aim, GST was purified from C. tarichi Pallas liver with 37.36% yield and 29.304 EU/mg specific activity using the chromatographic method. The Vmax values of liver GST were determined for CDNB and GSH to be 1.245 and 0.562 EU/mL, respectively, and the Km values were found 0.89 and 0.06 mM, respectively, using the Lineweaver–Burk plot.
8p
lyhuyenthu
31-01-2023
3
2
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Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxifcation of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine kinase inhibitors.
11p
viangelamerkel
27-07-2022
4
2
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Thiamine, an essential vitamin for aerobic metabolism and glutathione cycling, may decrease the effects of critical illnesses. The objective of this study was to determine whether intravenous thiamine administration can reduce vasopressor requirements in patients with septic shock.
9p
vizhangzhidong
29-12-2021
3
0
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Cardiac hypertrophy (CH), leading to cardiac failure is due to chronic metabolic alterations occurring during cellular stress. Besides the already known relationship between oxidative stress and CH, there are implications of reductive stress leading to CH. This study attempted to develop reductive stress-based CH rat model using n-acetyl-L-cysteine (NAC), a glutathione agonist that was compared with typical isoproterenol (ISO) induced CH model.
21p
thiencuuchu
27-11-2021
11
1
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The common deletion of the glutathione S-transferase Mu 1 (GSTM1) gene in humans has been shown to be involved in xenobiotic metabolism and associated with bladder cancer. However, the evolution of this deletion has not been investigated.
12p
vibeauty
23-10-2021
7
1
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Glutathione transferases (GSTs), the ancient, ubiquitous and multi-functional proteins, play significant roles in development, metabolism as well as abiotic and biotic stress responses in plants. Wheat is one of the most important crops, but the functions of GST genes in wheat were less studied.
15p
viansan2711
30-07-2021
7
1
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The glyoxalase pathway is evolutionarily conserved and involved in the glutathione-dependent detoxification of methylglyoxal (MG), a cytotoxic by-product of glycolysis. It acts via two metallo-enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII), to convert MG into D-lactate, which is further metabolized to pyruvate by D-lactate dehydrogenases (D-LDH).
19p
vijeeni2711
24-07-2021
3
0
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Fulvic acid (FA) is a kind of plant growth regulator, which can promote plant growth, play an important role in fighting against drought, improve plant stress resistance, increase production and improve quality. However, the function of FA in tea plants during drought stress remain largely unknown.
13p
vijeeni2711
24-07-2021
11
0
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The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-oral carbohydrate load and their influence on tumor characteristics and survival.
23p
vikuala271
13-06-2020
10
1
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Drought is the most important environmental stress that limits crop yield in a global warming world. Despite the compelling evidence of an important role of oxidized and reduced sulfur-containing compounds during the response of plants to drought stress (e.g. sulfate for stomata closure or glutathione for scavenging of reactive oxygen species), the assimilatory sulfate reduction pathway is almost not investigated at the molecular or at the whole plant level during drought.
15p
vihashirama2711
21-05-2020
20
1
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Hydrogen gas (H2) is hypothesised to play a role in plants that are coping with stresses by regulating signal transduction and gene expression. Although the beneficial role of H2 in plant tolerance to cadmium (Cd) has been investigated previously, the corresponding mechanism has not been elucidated.
19p
viharuno2711
21-04-2020
7
1
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The aim of the study was to evaluate the effect of titanium bone fixations on mitochondrial activity, reactive oxygen species (ROS) production, glutathione metabolism, and selected markers of oxidative/nitrosative stress in the periosteum-like tissue of patients treated with mandible fractures.
13p
vicaracas2711
27-11-2019
23
1
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Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism. Accumulation of ROS without an effective antioxidant response can lead to oxidative stress, resulting in macromolecular damage that is implicated in the etiology of various diseases including cancer.
6p
vikimsa
22-02-2019
17
1
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Reactive oxygen species (ROS) are products of normal metabolic activities and are thought to be the cause of many diseases. A selenium-containing single-chain abzyme 2F3 (Se-2F3-scFv) that imitates glutathione peroxidase has been produced which has the capacity to remove ROS. To evaluate the antioxidant ability of Se-2F3-scFv, we con-structeda ferrous sulfate/ascorbate (Vc/Fe 2+ )-inducedmito-chondrial damage model system and investigated the capacity of Se-2F3-scFv to protect mitochondria from oxi-dative damage.
6p
tumor12
20-04-2013
30
3
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GlutathioneS-transferases (GSTs) play critical roles in detoxification, response to oxidative stress, regeneration of S-thiolated proteins, and cata-lysis of reactions in nondetoxification metabolic pathways. Liver GSTs were purified from the anoxia-tolerant turtle,Trachemys scripta elegans. Purification separated a homodimeric (subunit relative molecular mass¼ 34 kDa) and a heterodimeric (subunit relative molecular mass¼32.6 and 36.8 kDa) form of GST.
13p
fptmusic
11-04-2013
40
1
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4-Hydroxy-2-trans-nonenal (4-HNE), one of the major end products of lipid peroxidation, has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signalingprocesses inmore thanonewaybecause it has been suggested to have a role in signaling for differentiation and proliferation. We showfor the first time that incorporation of 4-HNE-metabolizing glutathioneS-transferase (GST) isozyme, hGSTA4-4, into adherent cell lines HLE B-3 and CCL-75, by either cDNA transfection or microinjection of active enzyme, leads to their transformation. ...
12p
dell39
03-04-2013
45
2
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