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HBV reverse transcriptase
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Herein, the predicted atomic structures of five representative sequence variants of the reverse transcriptase protein (RT) of hepatitis B virus (HBV), sampled from patients with rapid or slow response to tenofovir disoproxil fumarate (TDF) treatment, have been examined to identify structural variations between them in order to assess structural and functional properties of HBV-RT variants associated with the differential responses to TDF treatment.
10p
vioklahoma2711
19-11-2020
12
1
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Entecavir (ETV) added to adefovir (ADV) is recommended in the consensus for management of patients with ADV resistance. However, little attention has been focused on the delayed reduction of HBV DNA and dynamics of ADV-resistant variants during ADV–ETV combination rescue therapy in the clinical setting.
7p
viwashington2711
04-12-2019
8
1
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Entecavir (ETV) đã được chấp thuận để điều trị viêm gan B mãn trên toàn thế giới. Entecavir là một chất ức chế mạnh và chọn lọc HBV DNA polymerase ảnh hưởng trên sự khởi động DNA, tổng hợp DNA và men sao chép ngược (reverse transcriptase).
3p
womanhood911_10
17-11-2009
350
67
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