Hematopoietic stem cells

In this study, we tested the ability of a specific culture medium supplemented with a cytokine cocktail to increase the number of total MNCs and thereby enrich CD34+UCHSCs. In addition, we investigated the effects of the bioactive peptide SL-13R on the proliferation of CD34+UC-HSCs at different culture time points and peptide doses.

7p xuanphongdacy06 18-09-2024 2 1   Download

High-risk neuroblastoma is a childhood malignancy with a poor prognosis. Gradual improvements in survival have correlated with therapeutic intensity, and the ability to harvest, process and store autologous hematopoietic stem cells has allowed for dose intensification beyond marrow tolerance.

5p vinatisu 29-08-2024 1 1   Download

The mixed-lineage leukemia (MLL) gene is located on chromosome 11q23. The MLL gene can be rear‑ ranged to generate partial tandem duplications (MLL-PTD), which occurs in about 5-10% of acute myeloid leukemia (AML) with a normal karyotype and in 5-6% of myelodysplastic syndrome (MDS) patients. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently one of the curative therapies available for AML and MDS with excess blasts (MDS-EB).

11p vielonmusk 21-01-2022 11 1   Download

Spermatogonial stem cells (SSCs) are pluripotent and have properties similar to embryonic stem cells. In this experiment, we collected SSCs from young mouse testis and injected it into mature female mice which were irradiated with gamma rays to bring them to a near death state.

9p tamynhan8 04-11-2020 9 1   Download

Tế bào gốc tạo máu (HSC: Hematopoietic Stem Cell) đã được nghiên cứu hơn nửa thế kỷ nay và là một trong những lĩnh vực tiến bộ và nổi bật nhất trong y sinh học hiện đại.

37p haokhitihon 21-03-2014 265 46   Download

Mobilization of hematopoietic stem and progenitor cells (HSPCs) from the bone marrow to the peripheral blood is utilized in clinical HSPC transplan-tation protocols. Retention of HSPCs in the bone marrow is determined by relationships between the chemokine chemokine (C-X-C motif) ligand 12 (CXCL12) and its major receptor

16p cosis54 09-12-2012 38 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Function, Adjustment, Quality of Life and Symptoms (FAQS) in Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Survivors: A Study Protocol

9p panasonic05 23-12-2011 53 4   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells from hematopoietic stem cells...

12p thulanh27 13-12-2011 49 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Enhanced self-renewal of hematopoietic stem/progenitor cells mediated by the stem cell gene Sall4...

14p thulanh25 06-12-2011 48 6   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation...

8p thulanh25 06-12-2011 57 6   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome...

3p thulanh25 06-12-2011 48 5   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Marked increase of procalcitonin after the administration of anti-thymocyte globulin in patients before hematopoietic stem cell transplantation does not indicate sepsis: a prospective study...

7p thulanh18 28-10-2011 48 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection...

12p toshiba15 24-10-2011 39 5   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology cung cấp cho các bạn kiến thức về ngành y đề tài: Hematopoietic stem cells and retroviral infection...

17p toshiba14 24-10-2011 55 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Hematopoietic stem cell transplantation for systemic lupus erythematosus...

3p thulanh11 11-10-2011 43 6   Download

Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia (CML) is 1.5 per 100,000 people per year, and the age-adjusted incidence is higher in men than in women (2.0 versus 1.2). The incidence of CML increases slowly with age until the middle forties, when it starts to rise rapidly. CML incidence for males decreased slightly (4.4%) between 1997 and 2003 as compared to 1977–1997. Definition The diagnosis of CML is established by identifying a clonal expansion of a hematopoietic stem cell possessing a reciprocal translocation between chromosomes 9 and 22.

5p thanhongan 07-12-2010 162 4   Download

Etiology Megakaryocytopoiesis and platelet production depend upon thrombopoietin and its receptor, Mpl. As in the case of early erythroid and myeloid progenitor cells, early megakaryocytic progenitors require the presence of interleukin 3 (IL-3) and stem cell factor for optimal proliferation in addition to thrombopoietin. Their subsequent development is also enhanced by the chemokine stromal cell–derived factor 1 (SDF-1). However, megakaryocyte maturation and differentiation require thrombopoietin.

5p thanhongan 07-12-2010 89 4   Download

Pneumocystis jiroveci pneumonia, once seen in 5–10% of patients, can be prevented by treating patients with oral trimethoprim-sulfamethoxazole for 1 week pretransplant and resuming the treatment once patients have engrafted. The risk of infection diminishes considerably beyond 3 months after transplant unless chronic Most GVHD transplant develops, centers requiring recommend continuous continuing immunosuppression. trimethoprim-sulfamethoxazole prophylaxis while patients are receiving any immunosuppressive drugs and also recommend careful monitoring for late CMV reactivation.

5p thanhongan 07-12-2010 57 4   Download

Graft Failure While complete and sustained engraftment is usually seen posttransplant, occasionally marrow function either does not return or, after a brief period of engraftment, is lost. Graft failure after autologous transplantation can be the result of inadequate numbers of stem cells being transplanted, damage during ex vivo treatment or storage, or exposure of the patient to myelotoxic agents posttransplant. Infections with cytomegalovirus (CMV) or human herpes virus type 6 have also been associated with loss of marrow function.

5p thanhongan 07-12-2010 62 5   Download

Graft-versus-Host Disease GVHD is the result of allogeneic T cells that were either transferred with the donor's stem cell inoculum or develop from it, reacting with antigenic targets on host cells. GVHD developing within the first 3 months posttransplant is termed acute GVHD, while GVHD developing or persisting beyond 3 months posttransplant is termed chronic GVHD.

5p thanhongan 07-12-2010 70 3   Download