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Heme oxygenase
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According to the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia primarily focused on low muscle strength with the detection of low muscle quality and quantity as confirming index.
9p
vinobelprisen
26-03-2022
13
5
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Ischemia-reperfusion (I/R) is a critical pathophysiological basis of cognitive dysfunction caused by ischemia stroke. Heme-oxygenase-1 (HO-1) is the rate-limiting enzyme for the elimination of excessive free heme by combining with hemopexin (HPX), a plasma protein that contributes to eliminating excessive free heme during ischemia stroke.
9p
vampires36
30-12-2021
7
0
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Ischemia-reperfusion (I/R) is a critical pathophysiological change of ischemic stroke. Heme-oxygenase-1 (HO-1) is a rate-limiting enzyme of eliminating excessive free heme by combining with hemopexin (HPX), a plasma protein contributing to alleviating infarct size due to ischemia stroke. This study was to investigate whether HPX could improve angiogenesis after cerebral ischemia-reperfusion via up-regulating HO-1.
7p
vampires36
30-12-2021
16
0
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Oxidative stress plays an important role in acute lung injury, which is associated with the development and progression of acute respiratory failure. Here, we investigated whether the degree of oxidative stress as indicated by serum heme oxygenase-1 (HO-1) is clinically useful for predicting prognosis among the patients with acute respiratory distress syndrome (ARDS) and acute exacerbation of interstitial lung disease (AE-ILD).
10p
vimichigan2711
26-03-2021
17
2
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Nerve growth factor (NGF) is a neurotrophin and has been suggested to induce heme oxygenase-1 (HO1) expression. Although the role of HO1 in tumorigenesis remains controversial, recent evidence suggests NGF and HO1 as tumor-progressing factors. However, the correlative role of NGF and HO1 and their prognostic impact in breast carcinoma is unknown.
10p
vijennie2711
29-09-2020
10
1
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Methionine adenosyltransferase 2A (MAT2A) is an enzyme that catalyzes the formation of S-adenosylmethionine (SAMe) by joining methionine and ATP. SAMe is a methyl donor for transmethylation and has an important role for DNA and/or protein methylation. MAT2A is expressed widely in many tissues especially in kidney. S
9p
virose2711
25-09-2020
11
1
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Heme oxygenase-1 (HO-1) and its major product carbon monoxide (CO) are known to be involved in the development and progression of many tumors. The present study was to elucidate the expression and function of HO-1 in colorectal cancer (CRC), specially focusing on the circulation CO levels in CRC patients and the possible roles of HO-1 in chemoresistance of colon cancer cells.
14p
virose2711
22-09-2020
7
2
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Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways. In healthy tissues, statins activate the heme oxygenase pathway, nevertheless the role of heme oxygenase in pancreatic cancer is still controversial.
11p
vinaypyidaw2711
26-08-2020
9
2
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Docosahexaenoic acid (DHA) is a long chain n-3 polyunsaturated fatty acid that has anticancer activity. Heme oxygenase 1 (HO-1) is a potential therapeutic target due to its cytoprotective activity in cancer cells.
10p
vimanila2711
25-06-2020
7
0
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Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration. The aim of this study was to determine the effects of leptin on the antioxidant response in three human mammary epithelial cells each presenting a different neoplastic status: healthy human mammary epithelial cells (HMEC), oestrogen-receptor positive MCF-7 cells and triple-negative MDA-MB-231 cells
13p
viputrajaya2711
22-06-2020
11
0
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Cadmium (Cd) is a well known environmental and industrial toxicant causing damaging effects in numerous organs. In this study, we examined the role of heme oxygenase-1 (HO-1) in modulating the Cd-induced apoptosis in human hepatoma (HepG2) cells after 24 h exposure.
13p
vienzym2711
30-03-2020
10
1
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Hyperbilirubinemia is a common disorder during neonatal period in Taiwan. Gene variants may play an important role in the development of neonatal hyperbilirubinemia. The current study investigated the association between neonatal hyperbilirubinemia and common gene variants involving the production and metabolism of bilirubin.
5p
videshiki2711
21-02-2020
41
1
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Exposure to high environmental temperature leading to increased core body temperature above 40°C and central nervous system abnormalities such as convulsions, delirium, or coma is defined as heat stroke.
5p
vivalletta2711
11-01-2020
8
0
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In a previous study, we found that induced expression of Heme Oxygenase-1 (HO-1) is responsible for the resistance of human osteosarcoma MG63 cells to the chemotherapeutic agent arsenic trioxide (ATO). The present study was aimed at investigating the molecular mechanisms underlying the induction of HO-1 that occurs after exposure of MG63 cells to ATO.
6p
viwashington2711
04-12-2019
5
1
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Antioxidant enzymes play a protective role in plants under oxidative stress. The present study explores the role of antioxidant system heme oxygenase1 (HO1) in Brassica juncea (L.) Czern. in salt stress conditions. B. juncea seedlings were treated with different NaCl concentrations (0–200 mM) for 5 days.
10p
vikimsa
22-02-2019
25
1
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Previously, we demonstrated apoptotic cell death in the chorion laeve trophoblast layer of human fetal membrane tissues during the late stages of pregnancy, the progression of apoptosis during incubation in vitro, and its suppression by a low concentration of glucocorticoid hormones.
8p
system191
01-06-2013
30
3
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Cytochrome P450BM3is a self-sufficient fatty acid mono-oxygenase consisting of a diflavin (FAD/FMN) reductase domain and a heme domain fused together in a single polypeptide chain. The multidomain structure makes it an ideal model system for studying the mechanism of electron transfer and for understanding P450 systems in general. Here we report the redox properties of the cyto-chrome P450BM3 wild-type holoenzyme, and its isolated FADreductase andP450 heme domains, when immobilized in a didodecyldimethylammonium bromide film cast on an edge-plane graphite electrode....
7p
tumor12
20-04-2013
44
2
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An efficient bacterial expression system of cyanobacterium Synechocystissp. PCC 6803 heme oxygenase gene, ho-1, has been constructed, using a synthetic gene. A soluble protein was expressedat high levels and was highly purified, for the first time. The protein binds equimolar free hemin to catabolize the boundhemin to ferric-bili-verdin IXa in the presence of oxygen andreducing equivalents, showing the heme oxygenase activity. During the reaction, verdoheme intermediate is formed with the evolution of carbon monoxide. ...
12p
tumor12
20-04-2013
29
2
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Two isoforms of a heme oxygenase gene,ho1andho2, with 51% identity in amino acid sequence have been identified in the cyanobacterium Synechocystissp. PCC 6803. Isoform-1, Syn HO-1, has been characterized, while isoform-2, Syn HO-2, has not. In this study, a full-lengthho2gene was cloned using synthetic DNA and Syn HO-2 was demonstrated to be highly expressed inEscherichia colias a soluble, catalytically active protein.
0p
awards
05-04-2013
37
1
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Heme oxygenase (HO) catalyzes the oxidative degradation of heme utilizing molecular oxygen and reducing equiva-lents. In photosynthetic organisms, HO functions in the biosynthesis of such open-chain tetrapyrroles as phyto-chromobilin and phycobilins, which are involved in the sig-nal transduction for light responses and light harvesting for photosynthesis, respectively.
9p
awards
05-04-2013
30
2
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