Hepatitis C virus

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  • The hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality worldwide. Infection with HCV becomes chronic in more than 80% of cases and it accounts for 20% of all cases of acute hepatitis. The hepatitis C virus was first identified by the molecular cloning of the virus genome in 1989.

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  • Chronic hepatitis C virus (HCV) infection is a main health problem in Egypt causing high rates of mortalities. Egypt has the highest HCV prevalence in the world, with specific HCV subtypes epidemic and circulating extensively in the country. Different antiviral therapy protocols have been implemented for treating Egyptian HCV patients. Due to the limited data about HCV in Egypt, this study aimed to genotype HCV strains circulating in the Nile Delta Damietta governorate and to investigate the variation in the nonstructural 5B (NS5B) region targeted by the newly approved antiviral drugs.

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  • The association between hepatitis C virus (HCV) infection and type 2 diabetes (T2D) has been known for over 20 years. Cross-sectional and longitudinal studies have shown a higher prevalence and incidence, respectively, of T2D in patients with chronic HCV infection. HCV induces glucose metabolism alterations mostly interfering with the insulin signaling chain in hepatocytes, although extrahepatic mechanisms seem to contribute.

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  • Chronic hepatitis C virus (HCV) infection is a systemic disease that leads to increased risks of cirrhosis and its complications, as well as extrahepatic disturbances, including immune-related disorders and metabolic alterations such as insulin resistance and steatosis. Recent accumulating evidence suggests that HCV infection can increase cardiovascular risk, and that viral eradication can improve cardiovascular outcomes in the clinical setting. These data are strengthened by evidence identifying potential mechanisms (in)directly linking HCV infection to vascular damage.

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  • An association between hepatitis C virus infection and neuropsychiatric symptoms has been proposed for some years. A variety of studies have been undertaken to assess the nature and severity of these symptoms, which range from fatigue and depression to defects in attention and verbal reasoning. There is evidence of mild neurocognitive impairment in some patients with HCV infection, which is not fully attributable to liver dysfunction or psychosocial factors.

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  • Circulating microRNAs (miRNAs) play critical roles in pathogen–host interactions. Aberrant miRNA expression profiles might have specific characteristics for virus strains, and could serve as noninvasive biomarkers for screening and diagnosing infectious diseases. In this study, we aimed to find new potential miRNA biomarkers of hepatitis C virus (HCV) infection.

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  • This study is a cross-sectional study aimed to assess the rate of occurrence of secondary occult hepatitis C virus (HCV) infection in patients treated with the combination of sofosbuvir and daclatasvir. This study included 40 patients whose serum turned negative for HCV ribonucleic acid (HCV RNA) via real time polymerase chain reaction (RT-PCR) after 3 months of the treatment. Blood samples on EDTA were collected from the patients to detect HCV RNA in peripheral blood mononuclear cells (PBMCs).

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  • Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis and primary hepatocellular carcinoma in most parts of the world. The prevalence of HCV infection worldwide has been estimated to be about 3%. Hence the present study was carried out to detect the prevalence of hepatitis C in patients of chronic liver disease. Eighty patients with clinically suspected Chronic Liver Disease attending the outpatient department or admitted in the K R Hospital attached to Mysore Medical College and Research Institute, Mysore from January 2012 to December 2012, were screened for anti-HCV.

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  • There is currently no evidence that hepatitis C virus (HCV) genotype affects survival in patients with hepatocellular carcinoma (HCC). This study aimed to investigate whether the HCV genotype affected the survival rate of patients with HCV-related HCC.

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  • Hepatitis C virus (HCV) infects many people worldwide and it is a leading cause of cirrhosis and hepatocellular carcinoma. Natural Killer (NK) cells have an important role during HCV infection as a part of innate immune responses. Three subtypes of NK cells are recognized: CD56dim CD16+ve, CD56bright CD16+ve and CD56–veCD16+ve. Natural killers T (NKT) (CD3CD16CD56+ve) cells are subsets of T lymphocytes that help in innate immune response because they can be directly cytotoxic.

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  • Autoimmune endocrine disorders are considered one of the extrahepatic manifestations of Hepatitis C virus (HCV) infection. HCV could trigger cytokines release due to local inflammation. Interleukin 17 a (IL17a) and Interferon gamma (IFNγ) play an important role in pathogenesis of autoimmune disease. Herein, we tried to assess the serum levels of IL17a and IFN-gamma in cirrhotic HCV infected patients with autoimmune thyroiditis. Serum samples were collected from 183 cirrhotic HCV infected patients.

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  • We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-HCV and anticancer effects was explored.

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  • Hepatitis C infection is a liver disease caused by the hepatitis C virus (HCV). It is one of the important risk factor causing acute to chronic illness in form of altered liver functions or development of chronic hepatitis, cirrhosis, hepatocellular carcinoma and liver failure.

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  • Since the discovery of hepatitis C virus (HCV) in 1989, there has been an explosion of research and information on the virus. This is evidenced by the more than 20 000 papers onHCV(as of December, 2000), as well as the numerous reviews in journals and edited books. The purpose of this book is to present an overview of the diVerent disciplines that have contributed to an understanding of the virus, its diseases, current and proposed treatments, and much more.

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  • Hepatitis C virus clearance is expected in more than 95% of patients treated with direct-acting antivirals (DAAs). However, an extensive debate about the impact of DAAs on the development of hepatocellular carcinoma (HCC) is currently ongoing. This review aimed to explore currently available evidence about the relationship between DAAs and HCC development. The American studies and some European studies clearly showed no relation, while the Japanese and Egyptian studies and the other European studies showed an increased risk of developing HCC after DAA exposure.

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  • The pegylated interferon regimen has long been the lone effective management of chronic hepatitis C with modest response. The first appearance of protease inhibitors included boceprevir and telaprevir. However, their efficacy was limited to genotype 1. Recently, direct antiviral agents opened the gate for a real effective management of HCV, certainly after FDA approval of some compounds that further paved the way for the appearance of enormous potent direct antiviral agents that may achieve successful eradication of HCV.

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  • Genetic variation near the interferon lambda 3 (IFNL3) is known to be associated with response to pegylated interferon (pegIFN) and ribavirin combination therapy in patients with chronic hepatitis C virus (HCV) infection which is often accompanied by hepatic steatosis.

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  • This study was designed to investigate the impact of liver cirrhosis due to chronic hepatitis C virus (HCV) infection on the disease-free and overall survival of ovarian cancer patients undergoing a standard primary operation followed by standard chemotherapy.

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  • Chronic hepatitis C virus (HCV) infection remains a global health threat with 175 million carriers worldwide. Approximately 3% of the worldwide population is infected with the hepatitis C virus (HCV). Lymphoproliferative disorder (LPD) is a term that includes a wide spectrum of pathologies ranging from a minor expansion of a B-cell population (with no clinical significance) to an aggressive high-grade lymphoma. Such proliferations of B cells apparently can be triggered as a consequence of a chronic antigenic stimulation resulting from an HCV infection.

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  • Both Helicobacter pylori (HP) and hepatitis C virus (HCV) infections are endemic in Egypt. This work aimed to investigate the presence of HP in the liver of patients with chronic hepatitis C (CHC) and explore the relation between HP infection, liver histopathology and HCV viral load. The study included 60 patients with CHC. Virological, biochemical, liver biopsy and testing for anti-Hp and anti-schistosomal antibodies in serum were done. Liver tissues were examined for histopathological and presence of Hp by detection of HP 16S rRNA gene by PCR and sequence analysis.

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