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Histological analysis
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To explore challenges of liquid-based cytology (LBC) specimens for next-generation sequencing (NGS) in lung adenocarcinoma and evaluate the efficacy of targeted therapy. Methods A retrospective analysis was conducted on the NGS test of 357 cases of advanced lung adenocarcinoma LBC specimens and compared with results of histological specimens to assess the consistency. The impact of tumor cellularity on NGS test results was evaluated.
8p
vikoch
27-06-2024
1
1
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Part 1 book "Bancroft’s theory and practice of histological techniques" includes content: Pathology laboratory management; chemical safety in the laboratory; light microscopy; fixation of tissues; the gross room surgical cut up including sample handling; tissue processing; microtomy for paraffin and frozen sections; resin (plastic) embedding for microscopy and tissue analysis; theory of histological staining; the hematoxylins and eosin; automation in the histology department; connective and other mesenchymal tissues with their stains; carbohydrates; pigments and minerals; amyloid.
267p
muasambanhan10
11-04-2024
3
1
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Comprehensive mutational profiling data now available on all major cancers have led to proposals of novel molecular tumor classifications that modify or replace the established organ- and tissue-based tumor typing. The rationale behind such molecular reclassifications is that genetic alterations underlying cancer pathology predict response to therapy and may therefore offer a more precise view on cancer than histology.
17p
vibransone
28-03-2024
4
2
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While clinical factors such as age, grade, stage, and histological subtype provide physicians with information about patient prognosis, genomic data can further improve these predictions. Previous studies have shown that germline variants in known cancer driver genes are predictive of patient outcome.
18p
vibransone
28-03-2024
4
2
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Accurate lung cancer classification is crucial to guide therapeutic decisions. However, histological subtyping by pathologists requires tumor tissue—a necessity that is often intrinsically associated with procedural difficulties. The analysis of circulating tumor DNA present in minimal-invasive blood samples, referred to as liquid biopsies, could therefore emerge as an attractive alternative.
12p
vibransone
28-03-2024
6
2
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Part 1 book "Canine and feline liver cytology" includes content: Before the analysis - rules for interpretation of hepatic cytology, normal histology and cytology of the liver, nonspecific and reversible hepatocellular damage, intracytoplasmic and extracytoplasmic pathological accumulation, irreversible hepatocellular damage.
132p
muasambanhan08
23-02-2024
3
1
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The patient received intravenous antibiotics, antiviral medications, systemic corticosteroids and dual anticoagulation with aspirin and enoxaparin. Death outcome was reported on day 18 of illness despite aggressive supportive care. Histological analysis demonstrated that obstruction of the main pulmonary arthery and disseminated intravascular coagulation were the causes of death.
8p
vitiki
30-01-2024
2
2
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Human papillomavirus (HPV) has been confirmed as a major causative factor for malignant transformation of cervical epithelial cells and for the development of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. We carried out this study to investigate the association of different HPV genotypes and ages with immediate histological cervical lesions in opportunistic screening patients in a single center.
10p
vileonardodavinci
23-12-2023
6
3
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Uterine sarcomas are rare and aggressive gynaecologic malignancies, characterized by a relatively high recurrence rate and poor prognosis. The aim of this study was to investigate the clinicopathological features and explore the prognostic factors of these malignancies.
10p
vialfrednobel
23-12-2023
4
3
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Previous studies on cancer of unknown primary (CUP) mainly focus on treatment and prognosis in western populations and lacked clinical evaluation of different IHC markers, so this study aimed to evaluate characteristics of CUP and recommend a diagnostic strategy from a single center in China.
10p
vialfrednobel
23-12-2023
2
2
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Part 1 book "Transgenic mouse - Methods and protocols" includes content: Introduction - Strategies for developing genetically modified mice; genetic modification of the mouse - general technology – pronuclear and blastocyst injection; generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos; cryopreservation of mouse spermatozoa and in vitro fertilization; autopsy and histological analysis of the transgenic mouse; transgene design; inducible transgenic mouse models; lentiviral transgenesis; transgenesis in mouse embryonic stem cells.
175p
oursky09
12-11-2023
3
2
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DNA methylation is an essential factor in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer. The aim was to investigate the diagnostic value provided by methylation biomarkers of six tumor suppressor genes (ASTN1, DLX1, ITGA4, RXFP3, SOX17 and ZNF671) for cervical precancerous lesions and cervical cancer.
10p
vischultz
20-10-2023
2
1
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Endometrial carcinoma (EC) is one of the most common gynecological malignancies in China and globally, accounting for the fourth-prevalent cancer in women. Although numerous studies have confirmed prognostic value of The Cancer Genome Atlas (TCGA) molecular subgroups, it is unclear how they are combined with histological features.
13p
vischultz
20-10-2023
5
2
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Part 1 book "Transgenic mouse, methods and protocols" includes content: Introduction - Atrategies for developing genetically modified mice; genetic modification of the mouse - general technology – pronuclear and blastocyst injection; generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos; cryopreservation of mouse spermatozoa and in vitro fertilization,.... and other contents.
175p
oursky05
20-09-2023
2
1
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Thyroid cancer (TC) overall survival at 5 years was estimated at 97% in mainland France over 2010–2015. Its prognosis is known to be affected by patient age, tumor histology, size, and extension. This study aims to describe overall survival of thyroid cancer patients diagnosed between 2008 and 2018 in Martinique.
13p
vioracle
29-09-2023
3
2
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Agarose-paraffin double embedding assisted with 3D printing for high throughput rice root sectioning
Anatomical analysis of the plant tissues is an important technique used in plant research for studying the process of plant growth, development, adaptation to environmental stress as well as for characterizing gene localization. In Vietnam, most anatomical analysis for plant material was manually conducted which is time-consuming and labor-intensive.
7p
vimulcahy
18-09-2023
7
3
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It is common that cancer patients have different molecular signatures even though they have similar clinical features, such as histology, due to the heterogeneity of tumors. To overcome this variability, we previously developed a new approach incorporating prior biological knowledge that identifies knowledge-driven genomic interactions associated with outcomes of interest.
11p
visteverogers
24-06-2023
5
3
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We report here the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. Methods: Finnish Cancer Registry data by histological diagnosis and tumor location (2007–2017) for cases with diffuse large B-cell lymphoma.
8p
vikolindagrabar
27-07-2022
5
2
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It has been postulated that patient’s sex impacts response to immunotherapy. Sex modulation of immunotherapy benefit, however, has not yet been explored using patient-level data, where potential confounder, as well as histologic type, can be accounted for. Here we investigated the association between sex and chemoimmunotherapy efficacy for non-small cell lung cancer (NSCLC) using a large, nation-wide dataset.
8p
vielonmusk
21-01-2022
14
1
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Uterine cervical cancer (UCC) was the fourth leading cause of cancer death among women worldwide. The conventional MRI hardly revealing the microstructure information. This study aimed to compare the value of amide proton transfer-weighted imaging (APTWI) and diffusion kurtosis imaging (DKI) in evaluating the histological grade of cervical squamous carcinoma (CSC) in addition to routine diffusion-weighted imaging (DWI).
10p
vielonmusk
21-01-2022
20
1
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