HIV reverse transcriptase

Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have designed and synthesized 2 series, namely pyrazoline and pyrimidine containing quinoline derivatives as non nucleoside reverse transcriptase inhibitors (NNRTIs).

46p tudichquannguyet 29-11-2021 5 1   Download

In this work we created a simple dynamic model for HIV infection with three parameters: The concentration of HIV virus, the concentration of health and the infected T-cells. Using a ‘therapy starting moment’ and this dynamic model, we investigated the effectiveness of HIV drug treatment.

7p tamynhan9 02-12-2020 13 3   Download

In this study, clustering was performed using a bitmap representation of HIV reverse transcriptase and protease sequences, to produce an unsupervised classification of HIV sequences. The classification will aid our understanding of the interactions between mutations and drug resistance.

23p vikentucky2711 26-11-2020 7 1   Download

Drug resistance in HIV treatment is still a worldwide problem. Predicting resistance to antiretrovirals (ARVs) before starting any treatment is important. Prediction accuracy is essential, as low-accuracy predictions increase the risk of prescribing sub-optimal drug regimens leading to patients developing resistance sooner.

7p viflorida2711 30-10-2020 8 1   Download

Abacavir (ABC) and Zidovudine (AZT) based regimens are the preferred first line nucleoside reverse transcriptase (NRTIs) backbones being widely utilized for managing HIV infection in children. However, there is a dearth of data regarding the clinical outcomes and associated risk factors in Ethiopia.

9p vivalanbo2711 19-03-2020 18 2   Download

Trong công trình này, các chất ức chế phiên mã ngược non-nucleoside mới (Non-nucleoside reverse transcriptase inhibitors (NNRTIs)) được nghiên cứu thông qua phương pháp docking phân tử. Dữ liệu Diversity chứa 1420 hợp chất “giống thuốc” từ Viện Ung thư Quốc Gia Mỹ (National Cancer Institute (NCI)) được docking vào tâm liên kết của cấu trúc tinh thể phiên mã ngược HIV-1 RT (1fk9) bằng gói phần mềm Autodock 4.2.6.

6p gildur 30-11-2019 36 3   Download

2’,3’-Dideoxynucleosides (ddNs) are the most important class of compounds active against HIV/AIDS. They act as DNA chain terminators and competitive inhibitors of viral reverse transcriptase (RT). Currently, stavudine (d4T, Zerit) is one six drugs belonging to the ddNs family that are approved by the FDA. This article describes the synthesis of generic stavudine drug from thymidine in three steps. By mean of this synthesis, stavudine was obtained in a good yield. The structure of product and intermediate were established by NMR spectroscopies.

3p uocvong04 24-09-2015 34 2   Download

why are we working towards becoming the Greenest City and why now? Vancouver residents have an ecological footprint three times larger than the Earth can sustain. he decisions we make every day about how we move around the city, what we buy or eat, and how we deal with our waste means that we currently use far more than our fair share of the Earth’s resources.

43p doidieumuonnoi 11-06-2013 51 7   Download

When pasture is limited, grain and concentrates are easy fillers but can be expensive and its use must be managed in regards to animal health. The majority of dairy farms in Australia currently process grain by using the method of „dry-rolling‟. This is a process where grain with 10-12% moisture content is shattered and then fed to cows. The „shattering‟ of the grain increases its surface area which speeds up the rate of digestion in the rumen. In many other parts of the world such as the United Kingdom, grain is also „dry-rolled‟ but with much higher moisture...

398p conduongdinhmenh 07-05-2013 57 7   Download

We have recently expressed in bacteria the enzymatically active reverse transcriptase (RT) of bovine leukemia virus (BLV) [Perach, M. & Hizi, A. (1999) Virology 259, 176–189]. In the present study, we have studied in vitro two features of the DNA polymerase activity of BLV RT, the processivity of DNA synthesis and the fidelity of DNA synthesis. These properties were compared with those of the well-studied RTs of human immunodeficiency virus type 1 (HIV-1) and murine leukaemia virus (MLV).

9p research12 01-06-2013 37 3   Download

Tham khảo sách 'healthy media, vibrant societies - how strengthening the media can boost development in sub-saharan africa', văn hoá - nghệ thuật, báo chí - truyền thông phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

62p thamgiacongdong 02-05-2013 34 3   Download

To enhance usability, the Guide has been organized to follow the numbering of the CPR, with explanations and documentation information separately accessible through hyperlinks via the table of contents. Additional hyperlinks to relevant documents, such as the ACGME Policy and Procedures Manual, Institutional Requirements, ACGME Glossary of Terms and Common Acronyms, and FAQs are also included. Selected resources available on the ACGME website that might be especially useful for new program directors have been collected together as part of the Guide and are listed below. ...

28p thamgiacongdong 02-05-2013 69 8   Download

Infections. During infancy, a number of viruses have been associated with the inception of the asthmatic phenotype. Respiratory syncytial virus (RSV) and parainfluenza virus produce a pattern of symptoms including bronchiolitis that parallel many features of childhood asthma53,54. A number of long-term prospective studies of children admitted to the hospital with documented RSV have shown that approximately 40% will continue to wheeze or have asthma into later childhood53.

17p dacotaikhoan 26-04-2013 47 2   Download

The interest rate on 10-year Treasury bonds in the third quarter of 2010 has averaged less than 2.6 percent. 7 It is not plausible that interest rates could decline much further, even in response to the most extreme fiscal adjustment. The short-term rate in the United States is already at zero so it can literally fall no further, and the long-term rate will surely reach a plateau in excess of zero. After more than a decade of deflation, the interest rate on 10-year bonds in Japan is still 0.9 percent, leaving a real yield that is approximately the same as in...

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Th e effi ciency argument assumes that the predominant motiva- tion infl uencing the behavior of corporate executives while car- rying out their duties as an executive is personal fi nancial gain in the form of salary. It relies on closely linking the salary to the corporation’s performance, typically measured through the share price. Th is assumption has been explicitly used by those in favor of high executive pay justifi ed by links to corporate per- formance, such as Murphy and Jensen (1990).

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Helen of Troy I and II, 1983, were both made out of the broken parts of Balzae. In the Greek myth, Helen was captured by the Trojans. She was said to be the most beautiful woman who ever lived, and a flotilla of 1,000 ships was launched to save her. Helen of Troy I will presumably be the first sculpture that launches a thousand ships. Helen of Troy II, while still the same shape, is painted partly white and raised on a pyramid type base. It is almost as if in this second version we are allowed to peek under her skirt. Troy finally fell after a horse...

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I am sure you are familiar with Donald Trump. Is that true? Let them respond. Would you agree that he is a great businessman? Let them respond. After Trump became a multi-millionaire he made some bad financial decisions. In fact, he lost so much money that he went upside down $900 million. One day, Trump was walking in downtown Manhattan with this then wife, Marla Maples. He said, “Marla, you see that bum right there? He is worth $900 million more than I am.” Although Trump...

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As mentioned above, the first defensive strategy of the host against infection consists of a non-specific phase, where the mucus and its contents (for example defensin and lysozyme) play a major role. Other important soluble chemical factors are acute phase proteins such as C-reactive protein, interferon, lactoferrin, sIgA, and the complement system (159) . • Viruses. Defensin plays an important role in defence against both enveloped and non-enveloped viruses. This protein is present in immune cells, to assists in the killing of phagocytized pathogens.

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Lys101Glu is a drug resistance mutation in reverse transcriptase clinically observed in HIV-1 from infected patients treated with the non-nucleoside inhibitor (NNRTI) drugs nevirapine and efavirenz. In contrast to many NNRTI resistance mutations, Lys101(p66 subunit) is positioned at the sur-face of the NNRTI pocket where it interacts across the reverse transcrip-tase (RT) subunit interface with Glu138(p51 subunit).

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The MHS program in Environmental Health is designed to address the academic and practice needs of students in the diverse environmental health field. For some, it serves as a foundation and provides direction for further academic training in medical school or doctoral programs. For others, the knowledge base it provides allows them to successfully pursue positions that incorporate environmental health perspectives and practice activities.

62p nhamnhiqa 01-03-2013 91 1   Download