Human lung cancer
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CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8+ Tregs and their interaction with CD8+ T cells in the tumor microenvironment of human lung cancer.
12p vishanshan 27-06-2024 1 1 Download
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Recent studies show that human gut microbial composition can determine whether a patient is a responder or non-responder to immunotherapy but have not identified a common microbial signal shared by responding patients.
15p viellison 28-03-2024 8 2 Download
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ung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance and failure. Single-cell RNA sequencing (scRNA-seq) has been widely used to dissect the cellular composition and characterize the molecular properties of cancer cells and their tumor microenvironment in lung cancer.
18p viellison 28-03-2024 4 2 Download
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Ebook "Systems analysis of human multigene disorders" Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors.
134p duongthandue0501 28-02-2024 1 1 Download
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The presence of inorganic forms of arsenic in water causing a serious threat to human health. Exposure of arsenic can cause serious diseases such as skin discoloration, cancer of skin, kidney and lung, blood vessel diseases, high blood pressure, and reproductive disorders.
5p vimichaelfaraday 28-12-2023 4 3 Download
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Ebook "Ambient air pollution and health impact in China" focuses on the health impacts of air pollution in China, especially the epidemiology-based exposure-response functions for the mortality, morbidity, and hospital admissions for respiratory diseases, cardiovascular diseases, lung cancer, and mental health related to pollution. It also provides the latest estimates of the magnitude of the adverse effects of air pollution on the health of the Chinese population.
277p lucchinguyen 28-12-2023 7 2 Download
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Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated. Forty-one fresh lung adenocarcinoma (ADC) tissues were analyzed using flow cytometry for comprehensive immunoprotein. Formalin-fixed tissues were immunostained for hexokinase-2 (HK2) to assess cancer cell glycolysis.
11p vileonardodavinci 23-12-2023 6 3 Download
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SET domain containing 6 (SETD6) has been shown to be upregulated in multiple human cancers and can promote malignant cell survival. However, expression and function of SETD6 in lung adenocarcinoma (LUAD) remains unaddressed. This study aimed to demonstrate the expression pattern, biological roles and potential mechanisms by which SETD6 dysregulation is associated with LUAD.
12p vileonardodavinci 23-12-2023 4 2 Download
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Accumulating evidence has revealed that the gut microbiota influences the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. As a part of the human microbiome, Helicobacter pylori (H. pylori) was reported to be associated with reduced effectiveness of anti-PD1 immunotherapy in patients with non-small-cell lung cancer (NSCLC).
8p vialfrednobel 23-12-2023 7 3 Download
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Anlotinib is a multi-targeted receptor tyrosine kinase inhibitor (TKI) which has exhibited encouraging clinical activity in advanced non-small cell lung cancer (NSCLC) and soft tissue sarcoma. The present study aims to investigate the combinatory antitumor efect of anlotinib and raltitrexed on human esophageal squamous carcinoma cells and further explore the molecular mechanisms in vitro.
15p vischultz 20-10-2023 3 1 Download
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Antibody-drug conjugates (ADCs) that target human epidermal growth factor receptor 2 (HER2) are leading a new era of targeted cancer therapy. These drugs have also been associated with several fatal adverse events, such as pneumonia, interstitial lung disease, and infection. We performed a meta-analysis of randomized controlled trials (RCTs) to estimate the incidence and risk of fatal adverse events in cancer patients treated with HER2-targeted ADCs.
10p visharma 20-10-2023 5 3 Download
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The current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables (e.g., age, sex, TNM stage), new omics data have recently been introduced in clinical practice, thereby making more complex the decision-making process.
8p visharma 20-10-2023 4 2 Download
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Wilms’ tumour gene 1 (WT1) is clearly recognized as a tumour promoter in diversiform of human malignancies. Nevertheless, knowledge of its expression, functions and potential molecular mechanisms in non-small cell lung cancer (NSCLC) remains elusive.
15p vioracle 29-09-2023 4 2 Download
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Polyphyllin I (PPI) is a naturally active steroidal saponin that has good therapeutic effects in various cancers, such as liver and lung cancers. However, owing to its non-selective distribution in various tissues, it is toxic and has side effects on normal human organs while taking effect.
12p viberbers 09-08-2023 3 2 Download
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To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing haematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell lung cancer (SCLC).
10p vikolindagrabar 27-07-2022 6 2 Download
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Lung cancer is among the major diseases threatening human health. Although the immune response plays an important role in tumor development, its exact mechanisms are unclear.
12p viangelamerkel 27-07-2022 3 2 Download
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BCD-021 is a bevacizumab biosimilar which was shown to be equivalent to reference bevacizumab in a wide panel of physicochemical studies as well as preclinical studies in vitro and in vivo.
13p vipriyankagandhi 27-07-2022 1 1 Download
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Recombinant human granulocyte colony-stimulating factor (rhG-CSF) reduces neutropenia events and is widely used in cancer patients receiving chemotherapy. However, the effects of rhG-CSF on distant organ metastasis (DOM) in non-small-cell lung cancer (NSCLC) patients following postoperative chemotherapy are not clear.
13p viangelamerkel 27-07-2022 3 1 Download
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The WNT signal pathway has myriad family members, which are broadly involved in embryonic development and human cancer. Over-activation of WNT-β-Catenin signalling promotes cancer cell proliferation and survival.
14p viangelamerkel 27-07-2022 4 1 Download
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The study was conducted to: (1) Describe the understanding of the impacts of environmental pollution on the health of people in Vinh Tan and Phuoc The communes, Tuy Phong district, Binh Dinh province; (2) Describe the health issues in Vinh Tan and Phuoc The communes. The topic is a cross-sectional descriptive study using quantitative research methods.
6p visusanwojcicki 22-06-2022 6 1 Download