Identification of toxic

Heparin was immobilized on magnetic chitosan particles to be used as a tool for human plasma protein identification. Chitosan was magnetized by co-precipitation with Fe2+/Fe3+ (MAG-CH). Heparin was functionalized with carbodiimide and N-hydroxysuccinimide and covalently linked to MAG-CH (MAG-CH-hep).

9p viginny 30-12-2022 8 2   Download

A filamentous cyanobacterium Oscillatoria limosa was isolated from the Tri An Reservoir, and cultured in laboratory under controlled conditions. Microscopic observation was used for morphological identification. Microcystins (MCs) concentration was determined using Highperformance liquid chromatography (HPLC).

8p viellenkullman 13-05-2022 6 1   Download

Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies. Personalized chemotherapy is dependent on the identification and validation of biomarkers that can predict treatment outcome and/or risk of toxicity.

16p vidarwin 22-02-2022 18 1   Download

Post transcriptional gene regulation in wheat cultivars caused by boron (B) toxicity has not been reported to date. In this study, two wheat cultivars Bolal-2973 (B-tolerant) and Atay-85 (B-sensitive) were compared with regard to the transcriptional regulation of miR319, miR172 and miR398 and their plausible target genes in order to address differences in their performances under high B levels. The expression levels of Cu/ZnSOD gene were found to be greater in Atay exposed to toxic B compared to Bolal, as verified by stable expression level of miR398.

23p hanthienngao 30-11-2021 12 1   Download

Harmful cyanobacterial blooms (HCB) have become a global threat to human health and aquatic biota around the world. While the ecotoxicity of microcystins (MC) producing cyanobacteria such as Microcystis spp. has been studied extensively, little is known about toxic effects of others filamentus cyanobacteria such as Anabaena spp. In this study, several strains of Anabaena sp. were isolated from Tri An Reservoir and cultured under laboratory conditions. Microscopic observation was used for morphological identification.

4p viwinter2711 05-10-2021 15 1   Download

Barley is relatively sensitive to Aluminum (Al) toxicity among cereal crops, but shows a wide genotypic difference in Al tolerance. The well-known Al-tolerant mechanism in barley is related to Al exclusion mediated by a citrate transporter HvAACT1 (Al-activated citrate transporter 1). A 1-kb insertion in the promoter region of HvAACT1 gene results in a dramatic increase of its expression level, which only occurs in some Al-tolerant cultivars. However, Al-tolerant Tibetan wild barley accession XZ29 did not have the 1-kb insertion.

14p vitzuyu2711 29-09-2021 7 1   Download

As an important group of the multidrug efflux transporter family, the multidrug and toxic compound extrusion (MATE) family has a wide range of functions and is distributed in all kingdoms of living organisms. However, only two MATE genes in apple have been analyzed and genome-wide comprehensive analysis of MATE family is needed.

14p vitzuyu2711 29-09-2021 12 1   Download

Environmental toxicity from non-essential heavy metals such as cadmium (Cd), which is released from human activities and other environmental causes, is rapidly increasing. Wheat can accumulate high levels of Cd in edible tissues, which poses a major hazard to human health.

18p visilicon2711 20-08-2021 13 1   Download

Pinus massoniana Lamb. is an important afforestation tree species with high economic, ecological and medicinal values. Aluminum (Al) toxicity driven by soil acidification causes dieback of P. massoniana plantations.

13p vijichea2711 28-05-2021 8 1   Download

NipahVirus (NiV) is a zoonotic Virus which infects several animals and humans worldwide. Currently, there is no specific drug or vaccine to treat or control NiV infections. The present study is aimed to identify novel inhibitors of NiV from Indian medicinal plants. Glycoprotein was taken as target protein. Around 600 phytocompounds were taken from 10 Indian medicinal plants and subjected to Virtual Screening by using Libdock module from Discovery Studio 4.0. From these, the best 20 compounds were screened and evaluated for their Pharmacokinetic properties by using ADMETSAR and pKCSM tools.

14p trinhthamhodang9 16-12-2020 9 2   Download

Drug-induced liver injury (DILI) is a critical issue in drug development because DILI causes failures in clinical trials and the withdrawal of approved drugs from the market. There have been many attempts to predict the risk of DILI based on in vivo and in silico identification of hepatotoxic compounds.

10p viflorida2711 30-10-2020 14 2   Download

Biomarker discovery studies have been moving the focus from a single target gene to a set of target genes. However, the number of target genes in a drug should be minimum to avoid drug side-effect or toxicity. But still, the set of target genes should effectively block all possible paths of disease progression.

12p vicoachella2711 27-10-2020 11 0   Download

Toxic chemicals strictly controlled by the International Maritime Organization (IMO) are dangerous goods which can potentially cause environmental degradation in maritime transport. Within the seaports of Hai Phong - Quang Ninh, the volume of toxic chemicals accounted for about 1% of container throughput (over 56 million tons per year, 2017) and many incidents took place during goods loading and unloading at the ports. Although they did not cause significant environmental damages, the prevention of and response to these incidents have revealed many drawbacks.

11p caygaocaolon6 22-07-2020 20 1   Download

The progress of treatments of childhood acute lymphoblastic leukemia (ALL) has made it possible to reach a survival rate superior to 80%. However, the treatments lead to several long-term adverse effects, including cardiac toxicity.

8p vikuala271 13-06-2020 10 1   Download

The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents.

11p vijiraiya2711 27-05-2020 6 1   Download

India spent Rs. 2,96,431 Crore to import 143.813 MMT of crude oil during AprilNovember, 2016 showing a marked increase of 9.31% in quantity terms and 4.84% decrease in value terms over the same period of last year. Interspecific hybridization as prebreeding approach has been proved as an important approach to widen variability and potential plants emerged as derivatives have been effectively utilized in genetic improvement of Jatropha.

11p nguaconbaynhay5 11-05-2020 4 1   Download

Cutaneous adverse reactions (CARs) from antiepileptic drugs (AEDs) are common, ranging from mild to life-threatening, including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The identification of subjects carrying the HLA-B*15:02, an inherited allelic variant of the HLAB gene, and the avoidance of carbamazepine (CBZ) therapy in these subjects are strongly associated with a decrease in the incidence of carbamazepine-induced SJS/TEN. In spite of the strong genetic associations, the initiation of hypersensitivity for AEDs is still not very well characterized.

10p caothientrangnguyen 09-05-2020 10 1   Download

Vanillin, a type of phenolic released during the pre-treatment of lignocellulosic materials, is toxic to microorganisms and therefore its presence inhibits the fermentation. The vanillin can be reduced to vanillyl alcohol, which is much less toxic, by the ethanol producer Saccharomyces cerevisiae.

9p viuchiha2711 21-04-2020 13 1   Download

Pulmonary fungal infections are common potentially life-threatening conditions in immuno-compromised patients. Diagnosis represents a challenge due to the non-specific clinical manifestations. Empirical use of anti-fungal drug therapy has been a burden for years due to high cost and drug toxicity. This study was designed to determine the presence of Candida chest infection in immuno-compromised patients in Tanta University Hospitals. A total of 150 patients with chest infection were selected during the period from June 2015 till June 2017.

9p trinhthamhodang4 22-03-2020 13 1   Download

Phenol and its components are extremely toxic and can easily be isolated from different industrial sewage such as oil refinery, petrochemical industry and mines, especially chemical factories causing pollution in water bodies. Rivers and oceans are contaminated on a large scale with these toxic compounds. In the past, physicochemical method was used for the elimination of phenol and its compounds, but today, bioremediation is preferable.

8p trinhthamhodang4 22-03-2020 27 2   Download