Immune system response
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Traditional nanodrug delivery systems have some limitations, such as eliciting immune responses and inaccuracy in targeting tumor microenvironments. Targeted drugs (Sorafenib, Sora) nanometers (hollow mesoporous silicon, HMSN) were designed, and then coated with platelet membranes to form aPD-1-PLTM-HMSNs@Sora to enhance the precision of drug delivery systems to the tumor microenvironment, so that more effective immunotherapy was achieved.
12p vikoch 27-06-2024 1 1 Download
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Ebook "Innate immunity of plants, animals, and humans" wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.
248p ladongphongthanh1008 22-04-2024 4 2 Download
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Ebook "Self and nonself" focuses on the origin of the immune response during the development of multicellularity (Chapters 1-4). Bacteria have developed defense systems against viruses and conversely, viruses have devised escape mechanisms that allow infection. Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity known as the CRISPR-Cas, that confers resistance to mobile genetic elements.
338p tracanhphuonghoa1007 22-04-2024 1 1 Download
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Ebook "Mesenchymal stem cells and immunomodulation" explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response.
94p tracanhphuonghoa1007 22-04-2024 4 2 Download
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Part 2 book "Veterinary microbiology" includes content: Agents of subcutaneous mycoses; agents of systemic mycoses; parvoviridae; circoviridae; asfarviridae and iridoviridae; papillomaviridae and polyomaviridae; adenoviridae; herpesviridae; poxviridae; picornaviridae; caliciviridae; togaviridae and flaviviridae; orthomyxoviridae; bunyavirales; paramyxoviridae, pneumoviridae, filoviridae, and bornaviridae; rhabdoviridae; coronaviridae and tobanivi,... and other contents.
453p muasambanhan10 03-04-2024 8 1 Download
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The expression of antigens that are recognized by self-reactive T cells is essential for immune-mediated tumor rejection by immune checkpoint blockade (ICB) therapy. Growing evidence suggests that mutation-associated neoantigens drive ICB responses in tumors with high mutational burden.
10p vibransone 28-03-2024 6 2 Download
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Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysregulation.
18p vibransone 28-03-2024 11 1 Download
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Vaccines dramatically affect an individual’s adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus.
18p vioraclene 31-03-2024 6 2 Download
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Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses
The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies various inflammation-mediated diseases, but the role of rare variants relative to common variants in immune response variability in healthy individuals remains unclear.
17p vibransone 28-03-2024 3 2 Download
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Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block immune inhibitory pathways. Administration of ICIs augments T cell-mediated immune responses against tumor, resulting in improved overall survival in cancer patients. It has emerged that the intestinal microbiome can modulate responses to ICIs via the host immune system and that the use of antibiotics can lead to reduced efficacy of ICIs.
11p vibransone 28-03-2024 4 2 Download
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Ebook "Food allergens: Biochemistry and molecular nutrition" covers the topics of biochemistry, digestibility, and uptake in the gastrointestinal tract of the most important food allergens causing IgE-mediated food allergy that is believed to be responsible for most immediate-type, foodinduced hypersensitive reactions.
217p tudohanhtau1006 29-03-2024 4 2 Download
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Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from the use of pre-clinical models rather than human samples.
25p viellison 28-03-2024 3 1 Download
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Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p viellison 28-03-2024 3 2 Download
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The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant contact with the brain borders, thus permitting insights into the brain to diagnose and monitor diseases. Recently, the meninges, which are filled with CSF, were identified as a neuroimmunological interface, highlighting the potential of exploring central nervous system (CNS) immunity by studying CNS border compartments.
12p viellison 28-03-2024 5 2 Download
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T-cells play a crucial role in the adaptive immune system by triggering responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, which has sparked interest in the development of various T-cell-focused immunotherapies.
24p vicwell 29-02-2024 3 1 Download
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Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau pathology and the local inflammatory response within the brain influence the broader immune system.
22p vicwell 29-02-2024 2 1 Download
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Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection.
24p vicwell 29-02-2024 1 1 Download
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Ebook "Crossroads between innate and adaptive immunity IV (Advances in experimental medicine and biology, Volume 785)" presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.
144p duongthandue0501 28-02-2024 1 1 Download
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Ebook "Classical and spatial stochastic processes: With applications to biology (Second edition)" presents the concepts and applications of random processes with the same illuminating simplicity as its first edition, but with the notable addition of substantial modern material on biological modeling. While still treating many important problems in fields such as engineering and mathematical physics, the book also focuses on the highly relevant topics of cancerous mutations, influenza evolution, drug resistance, and immune response.
271p manmanthanhla0201 26-02-2024 4 1 Download
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Cryptococcal meningitis (CM) is an inflammatory mycosis of the central nervous system caused by meninge infection or brain parenchyma with Cryptococcus species. It is associated with high morbidity and mortality, and patients with acquired immune deficiency syndrome are particularly susceptible.
6p vitiki 30-01-2024 4 2 Download