Increased functional limitations

Anthocyanins are colored bioactive phytochemicals in the class of flavonoids with high potential as dietary antioxidants. Demand for anthocyanins in functional food and nutraceutical industries has continued to increase over the past decades. However, sources of anthocyanins for commercial exploitation are currently limited.

7p viisac 23-09-2023 2 1   Download

Prevalence of frailty has been previously established in different Western countries; however, the prevalence and the burden of in the aging populations of Saudi Arabia has not been examined. Therefore, the aim of this study was to examine the prevalence of frailty, and associated factors among Saudi older population.

8p viisaacnewton 25-04-2022 9 5   Download

Sepsis-induced cardiac dysfunction may limit fluid responsiveness and the mechanism thereof remains unclear. Since cardiac function may affect the relative value of cardiac filling pressures, such as the recommended central venous pressure (CVP), versus filling volumes in guiding fluid loading, we studied these parameters as determinants of fluid responsiveness, according to cardiac function.

8p viisaacnewton 26-04-2022 10 1   Download

Declining functionality affects an individual’s musculoskeletal integrity increasing the risk of fall and disability. Individuals with severe functional limitations are 5 times more likely to experience a fall. Thus, this paper investigated the association between functional decline and falls in older adults.

7p vinobelprisen 26-03-2022 12 4   Download

The explosive growth of genomic data provides an opportunity to make increased use of sequence variations for phenotype prediction. We have developed a prediction machine for quantitative phenotypes (WhoGEM) that overcomes some of the bottlenecks limiting the current methods.

20p vigalileogalilei 27-02-2022 8 1   Download

Examples of heterozygote advantage in humans are scarce and limited to protein-coding sequences. Here, we attempt a genome-wide functional inference of advantageous heterozygosity at cis-regulatory regions.

15p viaristotle 29-01-2022 7 0   Download

Density functional theory was employed to investigate a series of phthalocyanine derivatives, discovering the limitation when the expansion of the conjugated system was employed to improve the hyper-Rayleigh scattering response coefficient. Furthermore, an unusually C∞v -type octupolar population was found by electrostatic potential analysis. In addition, the dynamic and static hyper-Rayleigh scattering responses (βHRS) were simulated using the coupled perturbed density functional theory, showing an increasing dynamic βHRS value along with an increase in incident light energy.

10p langthannam 29-12-2021 6 0   Download

: Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity.

7p thiencuuchu 27-11-2021 6 1   Download

Enhancers are distal cis-regulatory elements that control gene expression. Despite an increasing appreciation of the importance of enhancers in cellular function and disease, our knowledge of enhancer-regulated transcription is very limited.

18p vitzuyu2711 29-09-2021 11 1   Download

Low back pain (LBP) affects more than one third of the population at any given time, and chronic LBP is responsible for increased medical costs, functional limitations and decreased quality of life. A clear etiology is often difficult to identify, but aberrant posture and movement are considered contributing factors to chronic LBP that are addressed during physiotherapy intervention.

9p vitennessee2711 02-02-2021 11 2   Download

The incidence of proximal humeral fractures (PHF) increased by more than 30% over the last decade, which is accompanied by an increased number of operations. However, the evidence on operative vs. non-operative treatment and post-operative treatments is limited and mostly based on expert opinion.

8p vivermont2711 28-01-2021 7 2   Download

An understanding of the insertional footprints of the capsular ligaments of the hip is important for preserving hip function and stability given the increasing number of minimally invasive hip surgeries being performed under a limited surgical view.

8p vimariana2711 22-12-2020 15 1   Download

Integrative analysis of multi-omics data is becoming increasingly important to unravel functional mechanisms of complex diseases. However, the currently available multi-omics datasets inevitably suffer from missing values due to technical limitations and various constrains in experiments.

12p vioklahoma2711 19-11-2020 26 1   Download

The increasing volume and complexity of high-throughput genomic data make analysis and prioritization of variants difficult for researchers with limited bioinformatics skills. Variant Ranker allows researchers to rank identified variants and determine the most confident variants for experimental validation.

9p viflorida2711 30-10-2020 11 2   Download

Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study was to investigate the function of miRNA-146a (miR-146a) in DDP-resistant non-small cell lung cancer (NSCLC), as well as the underlying mechanisms.

14p vimale2711 21-08-2020 9 2   Download

A 7 years old female Labrador dog was presented with the history of alopecia with pruritis and inappetance for the past three months. Physical examination revealed bilateral alopecia with hyperpigmentation of skin. Thyroid function tests revealed decrease in T3 and T4 and increase in TSH values and thus indicating hypothyroidism. Haematological and other biochemical parameters were found be within normal limits except leukocytosis. Based on the laboratory findings the animal was treated with Levothyroxine sodium (Eltroxin tab) @20 μg/kg body weight PO, q 12hrs.

4p nguaconbaynhay6 23-06-2020 11 0   Download

Miscanthus is a promising biomass crop for temperate regions. Despite the increasing interest in this plant, limited sequence information has constrained research into its biology, physiology, and breeding.

10p viminato2711 22-05-2020 8 1   Download

Fertility augmentation approaches Fertility is one of the key determinants of the life time reproductive performance of the dairy cattle (Bos taurus and Bos indicus) and riverine buffaloes (Bubalus bubalis) which is reflected by its genotype, physiological condition, nutrition and management. It is assessed by the ability of a dairy cow to produce one calf per year. Fertility in riverine buffalo is considerably lower than in cattle.

13p kethamoi4 16-04-2020 14 1   Download

The role of nutritional factors or dietary elements is much more important which comprise balancing of energy between energy expenditure and intake or other factors that contribute to prevent obesity. Obesity is a noteworthy public health issue whose incidence tends to increase continuously. Emerging scientific data over the previous decade recommends that dairy foods might be advantageous when incorporated into a moderate energy limited diet and perhaps for weight management too.

13p caygaocaolon3 09-03-2020 21 2   Download

Perinatal stroke is a leading cause of cerebral palsy and lifelong neurological morbidity. Studies on perinatal stroke outcomes are increasing, although examinations of its broader impact on parents and families have been limited.

11p vichengshin2711 26-02-2020 12 1   Download