Independent modulation

Patterns in expression data conserved across multiple independent disease studies are likely to represent important molecular events underlying the disease. We present the INSPIRE method to infer modules of co-expressed genes and the dependencies among the modules from multiple expression datasets that may contain different sets of genes.

31p vioraclene 31-03-2024 4 2   Download

As the main isoforms of membranous glucose transporters (GLUT), GLUT1 involves tumorigenesis, metastasis and prognosis in a variety of cancers. However, its role in breast cancer metastasis remains to be elucidated. Here we examined its transcriptional and survival data in patients with breast cancer from several independent databases including the Oncomine, Gene Expression Profling Interactive Analysis, Gene Expression across Normal and Tumor tissue, UALCAN, cBioPortal, Kaplan-Meier Plotter and PROGgeneV2.

15p vileonardodavinci 23-12-2023 6 2   Download

The Credit-Module System (CMS) has been applied in various countries in order to increase students’ independence and all-round competence. To investigate the attitudes and practices of undergraduate students towards CMS.

7p vispacex 16-11-2023 5 2   Download

We aimed to evaluate the clinical efficacy and prognostic significance of intensity-modulated radiotherapy (IMRT)-based salvage concurrent chemoradiotherapy (CCRT) for patients with locoregional recurrence cervical cancer after radical hysterectomy and evaluated two salvage radiotherapy modes—regional RT (involved-field RT combined with regional lymph nodes) and local RT (involved-field RT).

10p vioracle 29-09-2023 4 2   Download

Generalized loss of skeletal muscle mass (SMM) may modulate or otherwise affect the loss of masseter muscle mass and be responsible for low masseter muscle performance and strength (i.e., low oral function). Moreover, dentition status can afect oral function independent of the muscle state.

13p vinobelprisen 26-03-2022 13 4   Download

Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of three-dimensional quantitative structure–activity relationship (3D-QSAR) models were conducted using 36 aromatic compound congeners as the training set and eight aromatic compound congeners as the test set. Logarithms of experimental bioconcentration data (logBCF) were used as dependent variables and the physicochemical properties of the aromatic compound congeners were used as independent variables.

21p tudichquannguyet 29-11-2021 13 1   Download

In this paper, in order to construct a 3D quantitative structure–activity relationship (QSAR) model with the chlorobenzene (CB) molecular structure parameter as an independent variable and the octanol-water partition coefficient (KOW ) as a dependent variable, 9 kinds of CB molecules were used as training sets and 3 kinds of CB molecules were used as test sets. We adopted the QSAR module in the Sybyl-X2.0 software from the Tripos Corporation (USA).

20p tudichquannguyet 29-11-2021 11 2   Download

The three prime untranslated region (3′-UTR) is known to play a pivotal role in modulating gene expression by determining the fate of mRNA. Many crucial developmental events, such as mammalian spermatogenesis, tissue patterning, sex determination and neurogenesis, rely heavily on post-transcriptional regulation by the 3′-UTR. However, 3′-UTR biology seems to be a relatively untapped field, with only limited tools and 3′-UTR resources available. To elucidate the regulatory mechanisms of the 3′-UTR on gene expression, firstly the 3′-UTR sequences must be identified.

11p vilarryellison 29-10-2021 7 1   Download

Intermittent fasting and time-restricted diets are associated with lower risk biomarkers for cardiometabolic disease. The shared mechanisms underpinning the similar physiological response to these events is not established, but circadian rhythm could be involved. Here we investigated the transcriptional response to fasting in a large cross-sectional study of adipose and skin tissue from healthy volunteers (N = 625) controlling for confounders of circadian rhythm: time of day and season.

14p vitzuyu2711 29-09-2021 10 1   Download

The genome of Banana bunchy top virus (BBTV) consists of at least six circular, single-stranded DNA components of ~ 1 kb in length. Some BBTV isolates may also carry satellite DNA molecules that are not essential for BBTV infection.

13p visilicon2711 20-08-2021 8 1   Download

Analyzing the human transcriptome is crucial in advancing precision medicine, and the plethora of over half a million human microarray samples in the Gene Expression Omnibus (GEO) has enabled us to better characterize biological processes at the molecular level.

25p viconnecticut2711 28-10-2020 16 1   Download

Cervical cancer continues to threaten women’s health worldwide, and the incidence of cervical adenocarcinoma (AD) is rising in the developed countries. Previously, we showed that glucose-regulated protein 58 (Grp58) served as an independent factor predictive of poor prognosis of patients with cervical AD.

8p vilisa271 22-09-2020 9 1   Download

Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+ -dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts.

10p vimanila2711 29-06-2020 11 1   Download

Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.

13p caothientrangnguyen 09-05-2020 20 0   Download

Metabolic pathways are interconnected and yet relatively independent. Genes involved in metabolic modules are required for the modules to run. Study of the relationships between genes and metabolic modules improves the understanding of metabolic pathways in plants.

13p viharuno2711 21-04-2020 12 1   Download

Presents a method to realize FIR filter based on DSP Builder, FIR design using a relatively independent function of circuit module and subsystems in the design, it can easily realize the filtering function of FIR, simplified the design, modular design method greatly shortens the development cycle, make the system have been optimized in the chip area and timing analysis etc.

7p vivalletta2711 11-01-2020 11 0   Download

It is time to shift the arachidonic acid (ARA) paradigm from a harm-generating molecule to its status of polyunsaturated fatty acid essential for normal health. ARA is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. Arachidonic acid is obtained from food or by desaturation and chain elongation of the plant-rich essential fatty acid, linoleic acid.

9p trinhthamhodang1 14-11-2019 22 0   Download

Module D - Internal, governmental, and fraud audits. This module define internal auditing; describe internal audit institutions (e.g. IIA); describe how internal auditors interact with independent auditors; explain internal auditors’ independence problems; and list features of internal reports; explain the function of standards and measurements in economy, efficiency and program audits.

16p shiwo_ding8 26-06-2019 21 1   Download

After studying this chapter you will be able to: Define internal auditing; describe internal audit institutions (e.g. IIA); describe how internal auditors interact with independent auditors; explain internal auditors’ independence problems; and list features of internal reports; explain the function of standards and measurements in economy, efficiency and program audits.

22p thiendiadaodien_9 24-02-2019 42 1   Download

In addition, differentiation reversal was highly specific since, at physiologically significant concentrations, closely related serine proteases did not cause neurite retraction. Prothrombin and thrombin also reversed morphological differentiation in the SK-N-SH neuroblastoma cell line and in heterogeneous cultures of cells from various regions in the human foetal brain.

7p byphasse043256 12-01-2019 21 1   Download