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Inhibit bacterial
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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin.
261p
vimeyers
29-05-2024
5
1
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Ebook "Prokaryotic cell wall compounds: Structure and biochemistry" provides an up-to-date knowledge of the prokaryotic cell wall, including its structure, composition, synthesis, assembly, and some surface interactions. Topics concerning bacterial and archaeal polymeric cell wall structures, biological activities, growth and inhibition, cell wall interactions and the applications of cell wall components, especially in the field of nanobiotechnology, are presented.
518p
tachieuhoa
28-01-2024
5
2
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The gut microbiome plays an important role in immune modulation. Specifically, presence or absence of certain gut bacterial taxa has been associated with better antitumor immune responses. Furthermore, in trials using fecal microbiota transplantation (FMT) to treat melanoma patients unresponsive to immune checkpoint inhibitors (ICI), complete responses (CR), partial responses (PR), and durable stable disease (SD) have been observed.
11p
vileonardodavinci
23-12-2023
7
2
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Mangrove is one of the highly productive ecosystems and contains diverse plants and microbial communities. Bacterial endophytes from mangroves are considered as a prolific source of biological molecules with important functions in the protection of mangrove plants against herbivores, insects as well as pathogens.
11p
vicaptainmarvel
21-04-2023
8
2
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Bacterial biofilms can initiate chronic infections that become difficult to eradicate. There is an unmet need for effective therapeutic strategies that control and inhibit the growth of these biofilms. Herein, light sensitive mesoporous silica nanoparticles (MSNs) with photothermal (PTT) and antimicrobial combined capabilities have been developed.
9p
vironald
15-12-2022
2
2
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Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO
UTP-glucose-1-phosphoryl transferase (UGPase) catalyzes the synthesis of UDP-glucose, which is essential for generating the glycogen needed for the synthesis of bacterial lipopolysaccharide (LPS) and capsular polysaccharide, which play important roles in bacterial virulence. However, the molecular function of UGPase in Brucella is still unknown.
10p
vidarwin
23-02-2022
10
1
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Results showed that increasing in rotational speed from 0 rpm to 200 rpm converted cellulose-producing cells to non-cellulose-producing ones, leading to a significant decline in BC film formation. The increase in initial inoculum size from 0.01 g/L to 0.1 g/L reduced sugar concentration and surface area of the medium, and therefore inhibiting the formation of film-like cellulosic biomass.
13p
paddington36
04-01-2022
11
1
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The investigated bacteria found to have a strong ability to form biofilms with densities ranged from 0.67 to 0.80. Both tested extracts inhibited these biofilms with percentages ranged from 48 to 66% at sub-inhibitory concentrations (SICs) ranged from 0.04 to 0.16 mg/mL.
9p
schindler
30-12-2021
12
0
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The active methanol extracts were successively partitioned with organic solvents such n-hexane, ethyl acetate and butanol to yield organic layers. Among of the resulting organic layers, n-hexane and ethyl acetate layers of the two plants displayed effective inhibition against various filamentous fungal and bacterial growth. Through bioassay guided isolation, 1,8 dihydroxy anthraquinones and their derivatives were isolated from those bioactive layers using silica gel, reverse phase and sephadex LH20 column chromatography.
7p
mudbound
06-12-2021
15
1
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The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a–6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1- tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones.
17p
tudichquannguyet
29-11-2021
8
1
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Glycopeptide antibiotics inhibit bacterial cell-wall synthesis, and are important for the treatment of infections caused by multi drug-resistant strains of enterococci, streptococci and staphylococci. The main mechanism by which bacteria resist the action of glycopeptides is by producing a modified cell-wall in which the dipeptide D-Alanine-D-Alanine is substituted by D-Alanine-D-Lactate or D-Alanine-D-Serine. Recently, it has been shown that inorganic phosphate (Pi) induces hypersensitivity to vancomycin in Streptomyces coelicolor (which is highly resistant to the antibiotic in low-Pi media).
16p
vibeauty
23-10-2021
13
1
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Bowman-Birk inhibitors (BBI) are a family of serine-type protease inhibitors that modulate endogenous plant proteolytic activities during different phases of development. They also inhibit exogenous proteases as a component of plant defense mechanisms, and their overexpression can confer resistance to phytophagous herbivores and multiple fungal and bacterial pathogens.
21p
vilichoo2711
23-06-2021
11
1
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Benzimidazole scaffold containing chemical derivatives show superior biological activity. In view of this, we synthesized a combination of benzimidazole and aryl amides. The target compounds (6a-j) were synthesized using ethyl 3-iodobenzoate and benzimidazole as starting materials under microwave conditions. The synthesized compounds were screened against gram (+ve) and gram (-ve) bacteria as well as for their anti-oxidant activity. Compound 6a was proved to be most active in inhibiting the DPPH free radical.
6p
nguaconbaynhay11
16-04-2021
8
1
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In the current study, for the aims to determine chemicals combination and minimum inhibition concentration (MIC) to optimize BGs production.
12p
nguaconbaynhay11
16-04-2021
14
2
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Bacterial resistance against traditional antibiotics has posed a major problem nowadays and the phytoconstituents present in medicinal plants has the potential to combat bacterial infections. Leaves of Adhathoda vasica plant were screened for its medicinal property.
10p
nguaconbaynhay8
13-10-2020
15
2
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Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bacterial and anti-inflammation. Inflammation is an immunological response to external harmful stimuli and is regulated by an endogenous pyrogen and pleiotropic pro-inflammatory cytokine, tumor necrosis factor alpha (TNF-α).
12p
vilisa271
22-09-2020
16
1
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An experiment was conducted to find out the effective antibacterial chemicals and bioagents against the growth of Ralstonia solanacearum under in vitro conditions. Average inhibition was ranged from 6.2 mm (Copper hydroxide) to 20.05 mm (Streptocycline).
12p
cothumenhmong7
09-09-2020
14
2
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Total of 523 bacterial isolates were collected from studied children groups (7-10 years); caries-active (n=50), caries-free (n=50). From caries-active children, 325 isolates have belonged to 22 bacterial species, whereas, in caries-free children, 198 bacterial isolates have belonged to 18 species.
15p
trinhthamhodang7
31-08-2020
9
2
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The study revealed that, the aqueous, acetone and alcoholic extract of A.vasica at different concentrations (2, 4 and 6 %) were highly effective against three bacterial species.
9p
nguaconbaynhay7
15-08-2020
15
1
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The phylloplane and rhizosphere microbes of rose cv. Edward was isolated and nine bacteria were selected to observe their antagonistic efficacy against Diplocarpon rosae causing blackspot disease in rose. The per cent inhibition of mycelial growth of the fungi by bacterial isolates was observed. The bacterial isolates PB1 and PB2 recorded 100 per cent inhibition followed by SB1, PB2 and SB2 isolates.
10p
caygaocaolon6
30-07-2020
19
1
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