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Inhibited accordingly
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Ticagrelor is a direct and rapid-acting antagonist of the P2Y12-adenosine diphosphate receptor found on platelets. The drug is recommended as a first-line antiplatelet agent in patients with acute coronary syndromes, as evidenced in its superiority compared to clopidogrel according to the Platelet Inhibition and Patient Outcomes study.
4p
viintuit
26-09-2023
4
0
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The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy moieties to the phthalocyanine structure favors excellent solubilities in water, as well as providing an inhibition effect on carbonic anhydrase (CA) I and II isoenzymes and paraoxonase (PON1) enzyme. According to biological activity results, both complexes inhibited hCA I, hCA II, and PON1.
13p
tudichquannguyet
29-11-2021
15
1
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In this study, a new series of Mannich bases, 3-(aminomethyl)-6-{3-[4-(trifluoromethyl)phenyl]acryloyl}-2(3H)- benzoxazolones (1a–g), were synthesized by the Mannich reaction. Inhibitory effects of the newly synthesized compounds towards carbonic anhydrases (CAs) and acetylcholinesterase (AChE) enzymes were evaluated to find out new potential drug candidate compounds. According to the inhibitory activity results, Ki values of the compounds 1 and 1a–g were in the range of 12.3 ± 1.2 to 154.0 ± 9.3 nM against hCA I, and they were in the range of 8.6 ± 1.9 to 41.0 ± 5.5 nM against hCA II.
14p
tudichquannguyet
29-11-2021
6
1
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Caffeic acid phenethyl ester induces apoptosis in colorectal cancer cells via inhibition of survivin
According to the results, CAPE decreased cell viability in the RKO cell line in a dose-dependent manner. Likewise, CAPE induced apoptotic cell death in approximately 40% of the RKO cells. Furthermore, CAPE treatment increased the Serine 15 (Ser15) and Serine 46 (Ser46) phosphorylation of p53, while decreased the survivin expression. The results suggested that CAPE induced apoptosis by regulating p53 phosphorylation, leading to inhibition of the survivin expression.
11p
thiencuuchu
27-11-2021
3
1
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Low temperature severely depresses the uptake, translocation from the root to the shoot, and metabolism of nitrate and ammonium in thermophilic plants such as cucumber (Cucumis sativus). Plant growth is inhibited accordingly.
16p
vijichea2711
28-05-2021
4
1
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Dispersal of glioblastoma (GBM) cells leads to recurrence and poor prognosis. Accordingly, molecular pathways involved in dispersal are potential therapeutic targets. The mitogen activated protein kinase/extracellular signal regulated kinase (MAPK/ERK) pathway is commonly dysregulated in GBM, and targeting this pathway with MEK inhibitors has proven effective in controlling tumor growth.
11p
vimale2711
21-08-2020
9
1
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According to GLOBOSCAN, hepatocellular carcinoma (HCC) claimed 782,000 lives in 2018. The tyrosine kinase inhibitor sorafenib is used to treat HCC, but new anticancer agents targeting different pathways are urgently needed to improve outcomes for patients with advanced disease.
15p
viorochimaru2711
30-05-2020
8
1
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Gender-based pharmacokinetics and/or pharmacodynamics differences can result in differences in treatment which can accordingly affect the drug safety and/or efficacy. A new validated bio-analytical LC-MS/ MS method was developed for the estimation of ezogabine, a third-generation antiepileptic drug, in human plasma using oxcarbazepine as an internal standard (IS) and to study the gender effect on the pharmacokinetic parameters in Egyptian human subjects.
6p
partimesinhvien
08-05-2020
18
1
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The present study was designed to evaluate in vitro antimicrobial activity and antioxidant activity and anticancer activity of different five extracts of Euphorbia tirucalli Stem. Plant roots were extracted in different five solvents viz. Hexane, Chloroform, Methanol, Water and Methanol: Water (90:10) through Soxtherm according to polarity gradients. Aiming to investigate antimicrobial activities, agar well diffusion method was followed using five pathogenic bacteria and five fungi as test organisms.
9p
kethamoi4
18-04-2020
10
1
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Alternaria leaf blight of tomato caused by Alternaria solani is a soil inhabiting and airborne pathogen responsible for considerable loss in tomato production. In the absence of resistant cultivars, the use of fungicides and biocontrol agents to control the disease is one exercise training. When there is an epidemic outbreak for some reason, perhaps the use of fungicides are one of the best options available. These fungicides must be used judiciously according to the need, type of body involved and availability of new fungicides.
11p
chauchaungayxua3
07-02-2020
13
2
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Mastitis is one of the major factors obstructing the progress of the dairy industry. The use of antibiotics has been related with antibiotic-resistant pathogens. Consequently, several studies have been done in order to find natural alternatives. One of these alternatives is propolis which has been identified as an appropriate option according to recent studies of antibacterial, antiviral, antifungal, and antiprotozoal activity.
7p
kequaidan2
13-12-2019
17
0
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There are many researches on the role of pesticides used in agricultural applications in the ecosystem. However, detailed research on microbial flora, especially for metabolic activity products, has not been found. Therefore, in our study the effect on microbial flora of natural pesticide, bordeux mixture used in the control of plant harmful and diseases in agricultural applications was evaluated in terms of production of EPS and siderophore.
11p
nguaconbaynhay1
04-12-2019
39
2
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Reactive oxygen species (ROS) are produced as by-products of several intracellular metabolic pathways and are reduced to more stable molecules by several protective pathways. The presence of high levels of ROS can be associated with disturbance of cell function and could lead to apoptosis. The presence of ROS within the physiological range has many effects on several signalling pathways. In stem cells, this role can range between keeping the potency of the naive stem cells to differentiation towards a certain lineage.
7p
trinhthamhodang1
14-11-2019
15
0
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The corrosion inhibition of mild steel in 0.01M HCl acid solution by water extract of Green tea has been studied using electrochemical method. The results of the study reveal that the inhibition efficiency of the extract is found to vary with concentration and period of immersion. Thermodynamic consideration reveals that adsorption of Green tea extract on mild steel surface is spontaneous and occurs according to Langmuir adsorption isotherm. Physical adsorption mechanism has been proposed for the adsorption of the inhibitor from the values of some kinetic and thermodynamic parameters.
5p
blackwidow123
15-06-2018
37
1
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This paper introduces a Maximum Entropy dependency parser based on an efficient kbest Maximum Spanning Tree (MST) algorithm. Although recent work suggests that the edge-factored constraints of the MST algorithm significantly inhibit parsing accuracy, we show that generating the 50-best parses according to an edge-factored model has an oracle performance well above the 1-best performance of the best dependency parsers. This motivates our parsing approach, which is based on reranking the kbest parses generated by an edge-factored model. ...
8p
hongvang_1
16-04-2013
50
2
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Mitochondrial calcium overload has been implicated in the irreversible damage of reperfused heart. Accordingly, we studied the effect of an oxy-gen-bridged dinuclear ruthenium amine complex (Ru360 ), which is a select-ive and potent mitochondrial calcium uniporter blocker, on mitochondrial dysfunction and on the matrix free-calcium concentration in mitochondria isolated from reperfused rat hearts.
12p
fptmusic
11-04-2013
46
1
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Compounds that influence the rates of enzyme-catalyzed reactions are called modulators, moderators, or modifiers. Usually, the effect is to reduce the rate, and this is called inhibition. Sometimes the enzyme reaction is increased, and this is called activation. Accordingly, the compounds are termed inhibitors or activators. When studying these phenomena, one has to understand the molecular events.
21p
sinh_30
27-09-2010
135
24
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