Inhibitors

Helicobacter pylori is a bacterium associated with gastric diseases and disorders of the upper gastrointestinal tract. The gram-negative bacterium Helicobacter pylori is known as a persistent colonizer of the human stomach, and this bacteria is also involved in extra-intestinal diseases. In 1994, the International Agency for Research on Cancer, World Health Organization classified H. pylori as a class 1 carcinogen, the only bacterium given this classification.

11p vinara 11-01-2025 0 0   Download

Helicobacter pylori (H.pylori) associated chronic gastritis is a risk factor of gastric cancer. This study aims to confirm effect of H.pylori eradication of sequential therapy (RA-RCT) and compare with the standard triple-drug therapy (RCT), addition to evaluating the improvement about histology of chronic gastritis after treatment.

7p viuchiha 06-01-2025 1 0   Download

Colorectal cancer (CRC) is one of the most common malignant cancers of the colon worldwide. Several novel approaches to cancer treatment have emerged, including gene therapy, targeted therapy, and adjuvant therapies.

7p viharuno 03-01-2025 1 1   Download

Pancreatic lipase is one of the safest targets of anti-obesity drugs. To date, orlistat is the only pancreatic lipase inhibitor approved for the long-term treatment of obesity. Therefore, there is an elevated need to find new drugs for this disease.

6p viharuno 03-01-2025 1 1   Download

FtsZ is conserved in almost all bacteria and is an essential protein for bacterial cell division. The cell division is prevented by the inhibitors against FtsZ’s functions. Thus, FtsZ is known as an attractive, and underexploited novel antibacterial target protein. The aim of this research is searching for new antibacterial agents from 72 plants collected in Central Vietnam.

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Bài giảng “Managing chronic heart failure patient in chronic kidney disease” trình bày các nội dung: Epidemiology, pathophysiolog, management, modification of risk factors, angiotensin-converting enzyme inhibitors,… Mời các bạn cùng tham khảo nội dung chi tiết.

23p tsmttc_004 13-06-2015 65 8   Download

Bài giảng "Đái tháo đường type 2: Cập nhật điều trị" cung cấp cho học viên những nội dung gồm: sinh lý bệnh đái tháo đường type 2; vị trí tác động của các thuốc điều trị đái tháo đường type 2; thuốc ức chế men α-Glucosidase; Incertin và sự tiết insulin khi tăng đường vào cơ thể; tính lượng carbohydrate và đếm carbohydrate cho đái tháo đường type 2;... Mời các bạn cùng tham khảo!

55p hamoc 13-11-2024 3 1   Download

The specific research objectives of this study are: 1. The development of a high throughput method for evaluation of alloys (5xxx Al as model materials in this work) subject to pitting; 2. Understanding the roles of variation in functional groups' in determining the inhibition efficiency; 3. Elucidating the inhibition mechanisms; and 4. Unveiling the role of intermetallic present in Al matrix and their contribution to the inhibition mechanism, particularly the long-term durability of the inhibitor systems.

104p runthenight04 02-02-2023 11 2   Download

The study "Studies on film forming corrosion inhibitors on aluminium alloy, AA2024-T3" presents key aspects of the film forming behaviour of the selected inhibitors and the test methods used to evaluate the inhibitor induced films in a chloride solution. This study also aims to provide significant insights to the film tenacity, the influence of the molecular structure as well as the film stability in the absence of inhibitors to provide a deeper understanding of the film forming and film breakdown mechanisms.

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Detection and screening of genes related to biosynthesis of substances with protease inhibitory activity from microorganisms associated with sponge collected from the Mien trung sea of Vietnam by metagenomics method. Then, selective gene, expression of in vitro and determination of activity of the expressed protein.

27p capheviahe26 25-01-2021 18 3   Download

To describe the clinical and subclinical features of lung cancer patients with EGFR mutations before TKIs therapy and in the relapsed period. To identify the T790M mutation and MET amplification in patients with lung cancer and EGFR-TKIs resistance and the relationship with clinical and subclinical features.

29p cothumenhmong6 17-07-2020 14 2   Download

The selective effects of these inhibitors are governed by substituent at position 5. Kinetic studies and molecular docking simulation were performed for elucidating mechanisms of enzyme-inhibitor complex formation.

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Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 13 1   Download

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinical characterization of the pharmacokinetics of AR-42 in mice and rats.

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The main contents and objectives of the thesis: Synthesis of hydrotalcite bearing benzothiazolylthiosuccinic acid (BTS) modified by silane and applied in solventborne epoxy coating for corrosion protection of carbon steel.

31p xacxuoc4321 09-07-2019 26 7   Download

An optogenetic upgrade for the tet - OFF system fused the inhibitor to the blue light-responsive B-LID degron and optimized the performance of this construct with regard to the number of Med25VBD repeats. This approach resulted in an optogenetic upgrade of the popular Tet-OFF (TetR-VP64, tetO7-PhCMVmin)  system  that  allows tunable, blue light-inducible gene expression in HEK-293T  cells.

5p thuyancn 01-06-2015 30 5   Download

TÍNH CHẤT VI SINH HỌC: 2.Biến dưỡng và tăng trưởng: phụ thuộc vào tế bào ký chủ để sinh năng lượng. (ATP hoặc tái oxi hóa NADPH 3.Sức đề kháng: 60oC/10’ (Đa số ┼). -50oC→-60oC: giữ nhiều năm Phenol, Ether bất hoạt vi khuẩn Inhibitors of protein synthesis (tetracyclines, erythromycins) are effective in most clinical infections

19p shift_12 18-07-2013 116 7   Download

The K103N substitution is a frequently observed HIV-1 RT mutation in patients who do not respond to combinationtherapy. The drugs Efavirenz, MSC194 and PNU142721 belong to the recent generation of NNRTIs characterized by an improved resistance profile to the most common single point mutations within HIV-1 RT, including the K103N mutation. In the present study we present structural observations from Efavirenz in complex with wild-type protein and the K103N mutant and PNU142721 and MSC194 in complex with the K103N mutant.

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Certain amino acids, like glutamine and leucine, induce an anabolic response in liver. They activate p70 ribosomal protein S6 kinase (p70S6K) and acetyl-CoA carboxylase (ACC) involved in protein and fatty acids synthesis, respectively. In contrast, the AMP-activated protein kinase (AMPK), which senses the energy state of the cell and becomes activated under metabolic stress, inactivates by phosphorylation key enzymes in biosynthetic pathways thereby conserving ATP.

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The goal of this study was to determine the effects of a putative specific cytosolic phospholipase A2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3), on arachidonic acid (AA) release and lipid mediator biosynthesis by ionophore-stimulated human neutrophils. Initial studies indicated that AACOCF3 at concentrations 0–10 lM did not affect AA release from neutrophils. In contrast, AACOCF3 potently inhibited leukotriene B4 formation by ionophore-stimulated neutrophils (IC50  2.5 lM).

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