Inhibitory activities
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Lichens, formed by the symbiosis of fungi and algae or cyanobacteria, are increasingly recognized for their potential medicinal properties, including their potential to treat type 2 diabetes. Many studies have shown that the bioactive metabolites of lichens originate from their fungal partners. This study isolated the mycobiont from a Graphis lichen sample and investigated the antioxidant and α-glucosidase inhibitory activity of its ethyl acetate extract.
10p visergeyne 18-06-2024 2 0 Download
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The study on essential oils of various plantparts and their biological activities continues to be an important area of research and developmen. In the continuation of our current research on the identification of bioactive substances from plants of North East India.
21p viamancio 04-06-2024 2 0 Download
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Achyranthes aspera L., belongs to the genus Achyranthes (Amaranthaceae). It is a well-known medicine in traditional remedies in Viet Nam, China and India. A. aspera leaves has a bitter, sour taste, clearing heat, decongesting, low leprosy, strong blood circulation. This paper reported the isolation of five ecdysterols and a saponin from Achyranthes aspera.
9p viamancio 04-06-2024 2 0 Download
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In addition, their inhibitory activity on NO production and cytotoxic effects against human embryonic kidney cells (HEK-293A) and human hepatocellular carcinoma (HepG2) were evaluated. This is the first study of the phytochemical investigation of P. ginseng sprouts cultivated in Vietnam and ginseng sprouts also contained the same main active ginsenosides as in the 4–6-year old roots.
7p dianmotminh02 03-05-2024 4 1 Download
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Seven known compounds, including two neolignans, four lignans, and one flavane were isolated from the methanol extract of Pandanus tonkinenis fruits. Their structures were determined to be ficusal, vladinol F, medioresinol, syringaresinol, lariciresinol, secoisolariciresinol, and luteoliflavan by analysis of MS and NMR data as well as by comparison of their spectral data with those reported in the literature.
7p dianmotminh02 03-05-2024 3 1 Download
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Phytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7''R, 8''R)-hydnocarpin D, (7''R, 8''R)-hydnocarpin, sinaicitin, (-)-globulol, β-caryolanol, phytol, biochanin A, chrysoeriol, tanoside II and astragalin using NMR and MS spectral data. Among the isolates, (7''R, 8''R)-hydnocarpin showed good cytotoxic activity against KB, HepG-2, Lu and MCF-7 cancer cell lines with IC50 values from 13.99±0.62 ug/mL to 30.65±1.44 ug/mL.
6p dianmotminh02 03-05-2024 1 1 Download
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Resistance to pathogenic bacteria may lead to serious health problems. Scientists found that discovering novel antimicrobial compounds is possible by exploring rarely investigated environments. Therefore, this work focused on isolating and identifying some fungal strains collected from the Co To sea. We tested whether such strains can produce compounds with vital activities, including antibacterial and antifungal. The antimicrobial activity of the marine fungi crude extracts was performed by the Bioassay method in a 96-well tray.
10p dianmotminh02 03-05-2024 3 1 Download
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The winged-helix domain within the N-terminus of human MUS81 has been considered as potential target for drug development since the inhibition of this protein might significantly enhance the sensitivity of various cancer cells towards anticancer drugs. Nine cytotoxic triterpenoids previously purified from Helicteres hirsuta and Pterospermum truncatolobatum were selected for the docking experiment.
6p dianmotminh02 03-05-2024 1 1 Download
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Cancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells.
10p dianmotminh02 03-05-2024 3 1 Download
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This study would like to point out the potential compounds as inflammatory agents. Herein, we displayed the isolation and structural identification of thirteen compounds including ten flavonoids, one tannin, one triterpenoid, and one derivative of benzoic acid from the methanolic extract. Furthermore, all of them were evaluated the anti-inflammatory activity.
12p dianmotminh02 03-05-2024 1 1 Download
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Alpinia vietnamica H.Ð. Tran, Luu & Skornick was identified as a new species in 2019, which is widely distributed in Thua Thien Hue, Quang Nam, and Kon Tum provinces, Vietnam. The current study wishes to report phytochemical investigation, and the biological activities (cytotoxic, antioxidative, and α-glucosidase inhibitory) of isolated compounds.
5p dianmotminh02 03-05-2024 8 1 Download
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The essential oils were also tested for their antioxidant, anti-imflammatory, antimicrobial and cytotoxic activities. The HD essential oil sample showed inhibitory activity against 6/8 tested microorganisms, i.e., Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtillis, Candida albicans, and Saccharomyces cerevisiae. The MHD and EHD exhibited the inhibitory activity against three strains E. coli, A. niger and F. oxysporum. The UHD inhibited E. coli and F. oxysporum.
9p dianmotminh02 03-05-2024 8 1 Download
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A series of chalcone analogues were synthesized using Claisen-Schmidt condensation and assayed for in vitro inhibitory activity against α-glucosidase. The synthesis involved in solvent-free reaction conditions including NaOHcatalyzed grinding or microwave irradiation in the presence of a clay-based catalyst. Hydroxychalcones and 2′-hydroxychalcones were not isolated when using grinding method, while the microwave-assisted, clay-catalyzed synthesis gave these desired products. In addition, flavanones, cyclization products from 2′-hydroxychalcones were formed in both methods.
8p dianmotminh02 03-05-2024 5 1 Download
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p dianmotminh02 03-05-2024 2 2 Download
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From CHCl3-soluble extract of the leaves of Taxus wallichiana (Taxaceae), collected in Lam Dong Province, five compounds were isolated and identified as sciadopitysin, ginkgetin, (S)-(+)-rhododenol, (+)-erythro-N-benzoyl3-phenylisoserine methyl ester, and (−)-α-conidendrin (5). Their chemical structures were determined by 1D and 2D NMR spectra and comparison with published data. Except for (−)-α-conidendrin, these remaining compounds were first reported of Taxus wallichiana.
6p dianmotminh02 03-05-2024 5 3 Download
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The present study investigated the phytochemical and biological properties of the rhizomes C. aromatica. From the CHCl3 extract of C. aromatic rhizomes, six known compounds, including (-)-hannokinol, (3R,5R)-3,5-diacetoxy-1,7-bis(4- hydroxyphenyl)heptane, naringenin, 2-(4- (hydroxymethyl)phenyl)propan-2-ol, 5-hydroxymethylfurfural, and bisacurone, were isolated. All compounds were tested on the biological inhibitory activities against tyrosinase, αglucosidase, and urease. It was the first time all compounds were isolated from rhizomes of C. aromatica Salisb.
6p dianmotminh02 03-05-2024 2 2 Download
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The purpose of this study was to find the optimal conditions for extracting polyphenols from Vietnamese tropical almond leaves (Terminalia catappa L.) and to assess the anti-diabetic activities of the resulting extract. The polyphenol extraction from Vietnamese tropical almond leaves was optimized using the response surface methodology.
12p vioraclene 01-04-2024 2 0 Download
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The synthesized compounds' enzyme inhibition potential was tested against a-glucosidase, AChE, and BChE enzymes. As illustrated from the results of IC50, these compounds are observed as the active inhibitory potential for these enzymes. The cytotoxic activity by hemolytic Assay revealed that these compounds have mild exposure to cytotoxicity on RBCs.
10p visergey 02-04-2024 0 0 Download
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The liver X receptors (LXRs, NR1H2 and NR1H3) and peroxisome proliferator-activated receptor gamma (PPARG, NR1C3) nuclear receptor transcription factors (TFs) are master regulators of energy homeostasis. Intriguingly, recent studies suggest that these metabolic regulators also impact tumor cell proliferation.
16p vioraclene 31-03-2024 5 2 Download
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The present study was aimed at the determination of microscopic characteristics and chemical compositions as well as evaluating the antioxidant and acetylcholinesterase inhibitory activities of A. vietnamica.
8p vilarry 12-03-2024 5 2 Download