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Insulin secretion
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The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations.
15p
vioraclene
31-03-2024
3
2
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Insulinomas are rare neuroendocrine tumors that typically present with hypoglycemic crises. Peripheral neuropathy is an uncommon complication of insulinoma. Most clinicians expect peripheral neuropathy symptoms to reverse completely after the insulin-secreting tumor is resected, but this may be a misassumption.
10p
vitiki
30-01-2024
3
2
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Ebbok "Advances in stem cell therapy: Bench to bedside" reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals.
319p
lamquandat
28-12-2023
5
2
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Insulinoma is a rare but common functional neuroendocrine tumor that secretes an excess amount of insulin resulting in mostly fasting hypoglycemia but can also cause postprandial hypoglycemia. It usually presents with neuroglycopenic and autonomic sympathetic symptoms that resolve following the administration of dextrose.
3p
viintuit
26-09-2023
3
0
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Diabetes mellitus (DM), a group of chronic metabolic disorders characterized by hyperglycemia resulting from defects in insulin action and/or insulin secretion. It represents one of the main contributors to ill health and premature mortality worldwide and its prevalence has been rising during the last decades.
5p
viisac
23-09-2023
2
1
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Inappropriately high levels of insulin secretion can cause the potentially fatal condition of persistent hyperinsulinemic hypoglycemia of infancy. Our paper focuses on another cause of severe hypoglycemia, which can be easily missed.
5p
vidoctorstrange
06-05-2023
4
2
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Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-gorelated gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia.
9p
vinarcissa
21-03-2023
3
1
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Adipose tissue is recognized as a highly active metabolic and endocrine organ. The hormones secreted by this tissue play an important role in many biochemical processes. It is known that dysfunction of adipocytes can cause insulin resistance, type 2 diabetes or hyperlipidemia.
7p
vinarcissa
21-03-2023
5
1
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Both genetic and environmental factors contribute to type 2 diabetes development. We used consomic mice established from an animal type 2 diabetes model to identify susceptibility genes that contribute to type 2 diabetes development under specific environments.
11p
vihagrid
30-01-2023
7
3
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Diabetes is a group of diseases characterized by high levels of blood sugar for an extended period. Despite newer and effective therapy, current treatment is riddled with fundamental challenges. To overcome the adverse effects of existing drugs, regenerative medicine has emerged as an essential treatment, for which tissue engineering may serve as a foundation for the repair of pancreatic cells secreting insulin.
13p
viporsche
28-10-2022
8
2
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KCNJ11 gene, encoding ATP-sensitive channel subunits, involves in insulin secretion. The study aimed at investigating the distribution of the KCNJ11 E23K (rs5219) polymorphism and its association with prediabetes and type 2 diabetes (T2D) in Vietnamese population.
8p
vihennessey
26-09-2022
8
2
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Teucrium species have been used in folk medicine as antidiabetic, antiinflammatory, antiulcer, and antibacterial agents. We have explored in vitro antidiabetic impacts of 2 natural diterpenoids, alysine A and alysine B, isolated from Teucrium alyssifolium.
23p
tudichquannguyet
29-11-2021
4
0
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Leucine decarboxylase (LDC) is a recently proposed enzyme with no official enzyme commission number yet. It is encoded by the Mus musculus gene Gm853 which is expressed at kidneys, generating isopentylamine, an alkylmonoamine that has not been described to be formed by any metazoan enzyme yet. Although the relevance of LDC in mammalian physiology has not been fully determined, isopentylamine is a potential modulator which may have effects on insulin secretion and healthy gut microbiota formation.
16p
tudichquannguyet
29-11-2021
4
1
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Type 2 diabetes mellitus is characterized by insulin resistance and hypersecretion of insulin from the pancreas to compensate for decreased insulin sensitivity in the peripheral tissues. In later stages of the disease insulin-secreting beta cell degeneration commences and patients require insulin replacement therapy in order to accomplish proper regulation of their blood glucose. Endoplasmic reticulum (ER) stress in the beta cells is one of the factors contributing to this detrimental effect.
10p
thiencuuchu
27-11-2021
8
1
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Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta-cell function and may contribute to development of type 2 diabetes mellitus (T2DM). Whereas mechanisms of impaired glucosestimulated insulin secretion (GSIS) in FFA-treated beta-cells have been intensively studied, biological events preceding the secretory failure, when GSIS is accentuated, are poorly investigated.
11p
vitzuyu2711
29-09-2021
13
1
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The potassium inwardly rectifying channel, sub-family J, member 11 (KCNJ11), which is a pore-forming sub-unit of ATP sensitive potassium channels in pancreatic B-cells, plays a critical role in the regulation of insulin secretion. A non-synonymous E23K variant (SNP rs5219) in the KCNJ11 gene, which results from C to T transition and substitutes glutamate for lysine at position 23, is identified as a SNP associated with prediabetes and type 2 diabetes.
8p
tamynhan9
02-12-2020
14
2
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Diabetes mellitus is a common metabolic disorder of carbohydrate, fat, and protein metabolism. It is characterized by increased glucose levels (hyperglycemia). Diabetes mellitus arises due to defects in insulin secretion or action, or both. Solute carrier family 30 (Zinc transporter) member 8 also known as SLC30A8 is a human gene that codes for a Zinc transporter which in turn is associated to insulin secretion in humans.
5p
caygaocaolon8
07-11-2020
11
1
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Diabetes mellitus (DM) is a metabolic disorder of multiple etiologies characterized by absolute or relative deficiency of insulin secretion with or without varying degree of insulin resistance. Sedentary life style and obesity are two major epidemiological determinants of diabetes mellitus. In the present investigation hypoglycemic efficacy of methanol extract of Catharanthus roseus (Nayantara) of Apocyanaceae and Opuntia ficusindica of Cactaceae was tested on STZ induced mice diabetic models.
17p
chauchaungayxua8
03-10-2020
11
1
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Coriander is an annual seed spice crop, which belongs to family Apiaceae. It is native of Mediterranean region. The aromatic characters of plants are due to presence of linalool compound in essential oil of seeds. The green leaves of coriander are used in salads and are a good source of vitamin A and vitamin C. Major active constituents of coriander essential oils and fatty oil. The essential oil content of the weight of ripe and a dried fruit of coriander varies between 0.03 and 2.6% and the content of fatty oil varies between 9.9 and 27.7%.
7p
angicungduoc6
20-07-2020
9
1
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Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and alterations in carbohydrate, fat and protein metabolisms. Diabetes is associated with absolute or relative deficiencies in insulin secretion by pancreatic β-cells and/or insulin action. For the treatment of diabetes large numbers of herbal preparations are in vogue. Plant cells produced secondary metabolites which are biologically active constituents with therapeutic and prophylactic applications in humans.
40p
kequaidan4
05-05-2020
14
1
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