Integrin α2
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Part 2 book "Handbook of venoms and toxins of reptiles" includes content: Snake venom three finger toxins; sarafotoxins, the snake venom homologs of the endothelins; cysteine rich secretory proteins in reptile venoms; snake venomics and disintegrins - portrait and evolution of a family of snake venom integrin antagonists;... and other contents.
273p muasambanhan06 03-02-2024 2 1 Download
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Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease is determined to be the mutations in the ITGB2 gene that codes for CD18, the beta chain of beta-2 integrins, leads to decreased expression or functioning of CD18. This deficiency leads to severe impairment of leukocyte adhesion to the vascular wall and leukocyte migration to sites of infection and inflammation.
7p vimulcahy 18-09-2023 5 3 Download
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Prevascularization and mechanical stimulation have been reported as effective methods for the construction of functional bone tissue. However, their combined effects on osteogenic differentiation and its mechanism remain to be explored. Here, the effects of fluid shear stress (FSS) on osteogenic differentiation of rat bone-marrow-derived mesenchymal stem cells (BMSCs) when cocultured with human umbilical vein endothelial cells (HUVECs) were investigated, and underlying signaling mechanisms were further explored.
15p langthannam 29-12-2021 9 0 Download
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Severe non-allergic eosinophilic asthma (SNEA) is a rare asthma phenotype associated with severe clinical course, frequent exacerbations, and resistance to therapy, including high steroid doses. The key feature is type 2 inflammation with predominant airway eosinophilia.
12p vimaine2711 26-03-2021 10 2 Download
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Integrins are transmembrane receptors that mediate cell–extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechanism(s) of integrin activation leading to integrin-mediated signaling in trophoblast cell differentiation is unknown.
13p viwyoming2711 16-12-2020 10 2 Download
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Phosphatase of regenerating liver-3 (PRL-3), a protein tyrosine phosphatase, is highly expressed in multiple human cancers and strongly implicated in tumor progression and cancer metastasis. However, the mechanisms by which PRL-3 promotes cancer cell migration, invasion, and metastasis are not very well understood.
11p vijisoo2711 29-09-2020 9 1 Download
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Expression of integrin α3β1 is associated with tumor progression, metastasis, and poor prognosis in several cancers, including breast cancer. Moreover, preclinical studies have revealed important pro-tumorigenic and pro-metastatic functions for this integrin, including tumor growth, survival, invasion, and paracrine induction of angiogenesis.
12p virose2711 22-09-2020 10 2 Download
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Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism is not fully elucidated.
13p vinaypyidaw2711 26-08-2020 7 1 Download
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Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this integrin has also been reported on several solid tumors, including colorectal cancer. However, its functional role in the metastatic progression to the liver remains unknown.
17p vimanama2711 30-07-2020 10 3 Download
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Our previous studies have shown that integrin subunits β1, β2 and β3 were the core proteins of venous thrombi and potential useful biomarker of venous thromboembolism (VTE). Patients with acute infection have a high risk of VTE. In this study we explored that is there any relevance between core proteins and acute infection.
5p viwashington2711 04-12-2019 6 0 Download
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The risk of rheumatoid arthritis (RA), an autoimmune disease, in the elderly population increases along with that of atherosclerosis, cardiovascular disease, type 2 diabetes, and Alzheimer’s disease. Identifying specific biomarkers for RA can clarify the underlying molecular mechanisms and can aid diagnosis and patient care.
9p vinasaki2711 12-11-2019 5 0 Download
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The vertex of the adenoviral capsid is formed by the penton, a complex of two proteins, the pentameric penton base and the trimeric fiber protein. The penton contains all necessary components for viral attachment and entry into the host cell. After initial attachment via the head domain of the fiber protein, the penton base interacts with cellular integrins through an Arg-Gly-Asp (RGD) motif located in a hypervariable surface loop, trigger-ing virus internalization.
10p inspiron33 25-03-2013 38 4 Download
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Talins are large adaptor proteins that link the integrin family of adhesion molecules to F-actin. In vertebrates, there are two talin genes.Talin 1is essential for integrin-mediated cell adhesion; the role oftalin 2 is unclear. Here we report a detailed analysis of mammaliantalin 2.
19p vinaphone15 27-02-2013 29 2 Download
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To determine the reliability of applying these categories to specific song lyrics, two observers independently classified the reproductive themes present in written versions of the reproductively relevant phrases extracted from a representative sample of the Pop, Country, and R&B songs. The number of phrases containing reproductive messages ranged from 2 (“White Horse” and “Second Chance”) to 29 (“Baby By Me”) for a total of 219 reproductive phrases, with an average of 8.76 different reproductive references per song.
17p ut_hai_can 25-12-2012 43 4 Download
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Meliton et al. Journal of Inflammation 2010, 7:14 http://www.journal-inflammation.com/content/7/1/14 RESEARCH Research Open Access Cytosolic group IVa phospholipase A2 mediates IL-8/CXCL8-induced transmigration of human polymorphonuclear leukocytes in vitro Angelo Y Meliton1, Nilda M Muñoz*1, Lucille N Meliton1, David C Binder1, Christopher M Osan1, Xiangdong Zhu1, Steven M Dudek1 and Alan R Leff1,2 Abstract Background: Cytosolic gIVaPLA2 is a critical enzyme in the generation of arachidonate metabolites and in induction of β2-integrin adhesion in granulocytes.
8p thulanh27 12-12-2011 49 4 Download
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Không xâm lấn trực quan của integrin alphavbeta3 kích hoạt ở những bệnh nhân ung thư bằng cách chụp cắt lớp phát xạ positron và [(18) F] galacto-RGD. PLoS Med 2005; 2: E70. 172. Chen X, Park R, Shahinian AH, et al. 18F-dán nhãn RGD peptide: đánh giá ban đầu cho hình ảnh khối u não hình thành mạch máu.
59p meomap5 12-12-2011 73 5 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes...
9p thulanh16 21-10-2011 51 2 Download
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điều này cho phép xẩy ra sự tương tác chọn lọc của các tế bào khác nhau với các phân tử kết dính tế bào có trên các tế bào khác, hoặc dọc theo thành mạch. Ví dụ một integrin có kí hiệu là LFA-1 xuất hiện trên tất cả các loại bạch cầu, có thể nhận dạng một phân tử kết dính có tên là ICAM có trên nhiều loại tế bào trong đó có các tế bào nội mô của mao mạch đã được hoạt hoá. Một integrin khác có kí hiệu là VLA-4 mang tính đặc hiệu...
29p iiduongii2 02-04-2011 82 12 Download
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Tumor angiogenesis is a complex process involving many different cell types that must proliferate, migrate, invade, and differentiate in response to signals from the tumor microenvironment. Endothelial cells (ECs) sprout from host vessels in response to VEGF, bFGF, Ang2, and other proangiogenic stimuli. Sprouting is stimulated by VEGF/VEGFR2, Ang2/Tie-2, and integrin/extracellular matrix (ECM) interactions.
6p konheokonmummim 03-12-2010 78 6 Download
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Disorders of Adhesion Two main types of leukocyte adhesion deficiency (LAD) have been described, LAD 1 and LAD 2. Both are autosomal recessive traits and result in the inability of neutrophils to exit the circulation to sites of infection, leading to leukocytosis and increased susceptibility to infection (Fig. 61-8). Patients with LAD 1 have mutations in CD18, the common component of the integrins LFA-1, Mac-1, and p150,95, leading to a defect in tight adhesion between neutrophils and the endothelium.
5p konheokonmummim 03-12-2010 81 4 Download