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Intermediate ligand
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Ebook "Site-selective catalysis" focuses on (1) ligand-controlled site-selective cross-coupling, (2) iron-catalyzed site-selective oxidation of alkyl C– H bonds, (3) catalytic site-selective conjugate addition of conjugated dienones and trienones, (4) site-selective redox-triggered C–C coupling of diols, (5) site-selective cleavage of peptides and proteins, (6) catalyst-controlled site-selective molecular transformations of carbohydrates, (7) site-selective functionalization of complex natural products by peptide-based catalysts, and (8) site-selective acylation of carbohydrates and its app...
237p
tracanhphuonghoa1007
22-04-2024
2
2
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Ebook "Homogeneous gold catalysis (Topics in Current chemistry, Volume 357)" begins with a chapter by Malhotra, Hammond, and Xu, which highlights the interplay of ligand effects, substrate structure and mechanism in gold catalysis, using specific examples of ligand design and reactions mediated by gold–oxonium intermediates.
292p
tudohanhtau1006
29-03-2024
5
1
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In ebook "High- and low-valent tris-N-heterocyclic carbene iron complexes: A study of molecular and electronic structure" high valent iron nitride and oxo species have been proposed as key intermediates in many bio-catalytic transformations, but until now these species have proven exceedingly challenging to isolate and study. Iron complexes in high oxidation states can thus serve as models for iron-containing enzymes to help us understand biological systems or aid our development of more efficient industrial catalysts.
145p
nhanphanguyet
28-01-2024
8
2
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Giant cell tumor of the bone (GCTB) is classified as an intermediate, locally aggressive but rarely metastasizing tumor. The mainstay of treatment for the treatment of GCTB had been the surgical removal until an anti- receptor activator of nuclear factor-kappa B ligands (RANKL) antibody denosumab was developed.
7p
vioregon2711
22-02-2021
8
1
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Conventionally, human monocyte sub-populations are classified according to surface marker expression into classical (CD14++CD16− ), intermediate (CD14++CD16+ ) and non-classical (CD14+ CD16++) lineages. The involvement of non-classical monocytes, also referred to as proinflammatory monocytes, in the pathophysiology of diseases including diabetes mellitus, atherosclerosis or Alzheimer’s disease is well recognized.
9p
viuchiha2711
21-04-2020
11
1
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A new approach has been developed for the preparation of mixed-mode stationary phases to separate proteins. The pore surface of monolithic poly(glycidyl methacrylate-co-ethylene dimethacrylate) capillary columns was functionalized with thiols and coated with gold nanoparticles. The final mixed mode surface chemistry was formed by attaching, in a single step, alkanethiols, mercaptoalkanoic acids, and their mixtures on the free surface of attached gold nanoparticles. Use of these mixtures allowed fine tuning of the hydrophobic/hydrophilic balance.
8p
trinhthamhodang1
16-11-2019
14
1
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The recorded high resolution mass spectra when following the typical protocol for the asymmetric transfer hydrogenation of acetophenone confirmed an involvement of the active complex mono-hydride ruthenium in the catalytic circle. As a result, high resolution mass spectra in research on catalytic mechanism can be therefore employed as an alternative tool for studying catalytic mechanism.
6p
giesumanh
04-11-2018
14
1
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Methanol:coenzyme M methyltransferase from methanogenic archaea is a cobalamin-dependent enzyme composed of three different subunits: MtaA, MtaB and MtaC. MtaA is a zinc protein that catalyzes the methylation of coenzyme M (HS-CoM) with methylcob(III)alamin. We report zinc XAFS (X-ray absorption fine structure) results indicating that, in the absence of coenzyme M, zinc is probably coordinated by a single sulfur ligand and three oxygen or nitrogen ligands. In the presence of coenzyme M, one (N/O)-ligand was replaced by sulfur, most likely due to ligation of the thiol group of coenzyme M....
7p
research12
01-06-2013
51
4
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Resonance Raman spectroscopy has been used to observe changes in the iron–ligand stretching frequency in photo-product spectra of the proximal cavitymutant ofmyoglobin H93G. The measurements compare the deoxy ferrous state of the heme iron in H93G(L), where L is an exogenous imidazole ligand bound in the proximal cavity, to the pho-tolyzed intermediate of H93G(L)*CO at 8 ns.
8p
research12
29-04-2013
40
3
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The heterodimeric cytokine composed of the soluble ciliary neurotrophic factor receptor (sCNTFR) and the IL-6 family member cardiotrophin-like cytokine (CLC) was recently identi®ed as a new ligand for gp130±leukemia inhibitory factor receptor (LIFR) complex [Plun-Favreau, H., Elson, G., Chabbert, M., Froger, J., deLapeyriere, O., Lelievre, E., Guillet, C., Hermann, J., Gauchat, J. F., Gascan, H. & Chevalier, S. (2001)EMBO J.20, 1692± 1703]. This heterodimer shows overlapping biological properties with LIF....
10p
research12
23-04-2013
27
1
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Primary olfactory neuronal cultures exposed to odorant stimulation have previously exhibited concentration-related effects in terms of intracellular cAMP levels and adenylate cyclase activity [Ronnett, G.V., Parfitt, D.J., Hester, L.D. & Snyder, S.H. (1991)PNAS88, 2366–2369].Maximal sti-mulation occurred for intermediate concentrations, whereas AC activity declined for both low and high odorant con-centrations.We suspected that this behavior might be ascribed to the intrinsic response of the first molecular species concerned by odorant detection, i.e. the olfactory receptor itself....
8p
fptmusic
16-04-2013
35
1
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To investigate the structural function of the C-terminal amide group of endomorphin-2 (EM2, H-Tyr-Pro-Phe-Phe-NH2), an endogenous l-opioid receptor ligand, the solution conformations of EM2 and its C-terminal free acid (EM2OH, H-Tyr-Pro-Phe-Phe-OH) in TFE (trifluoroethanol), water (pH 2.7 and 5.2), and aqueous DPC (dodecylphosphocholine) micelles (pH 3.5 and 5.2) were investigated by the combination of 2D 1 H-NMR meas-urement and molecular modelling calculation.
19p
fptmusic
12-04-2013
29
2
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Conformational changes in the calpain molecule following interaction with natural ligands can be monitored by the binding of a specific monoclonal antibody directed against the catalytic domain of the protease. None of these conformational states showed catalytic activity and probably repre-sent intermediate forms preceding the active enzyme state.
9p
inspiron33
26-03-2013
43
4
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Antibodies are the paradigm for binding proteins, with their hypervariable loop region supported by a structurally rigid framework, thus providing the vast repertoire of antigen-binding sites in the immune system. Lipoca-lins are another family of proteins that exhibit a binding site with high structural plasticity, which is composed of four peptide loops mounted on a stable b-barrel scaffold.
7p
galaxyss3
07-03-2013
42
2
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The oligomeric state and kinetics of ligand binding were measured for wild-type cytoglobin. Cytoglobin has the classical globin fold, with an extension at each extremity of about 20 residues. The extended length of cytoglobin leads to an ambiguous interpretation of its oligomeric state.
9p
mobifone23
21-01-2013
48
3
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The truncated C-terminal portion of Bid (tBid) is an important intermedi-ate in ligand-induced apoptosis. tBid has been shown to be sensitive to pro-teasomal inhibitors and downregulated by activation of the epidermal growth factor (EGF) pathway. Here, we provide evidence that tBid is a substrate of the ubiquitin ligase Itch, which can specifically interact with and ubiquitinate tBid, but not intact Bid.
12p
mobifone23
18-01-2013
34
5
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CD91 plays an important role in the scavenging of apoptotic material, pos-sibly through binding to soluble pattern-recognition molecules. In this study, we investigated the interaction of CD91 with mannan-binding lectin (MBL), ficolins and lung surfactant proteins. Both MBL and L-ficolin were found to bind CD91. The MBL–CD91 interaction was time- and concentra-tion-dependent and could be inhibited by known ligands of CD91.
9p
mobifone23
08-01-2013
39
3
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The topoisomerase I (TopI) reaction intermediate consists of an enzyme covalently linked to a nicked DNA molecule, known as a TopI-DNA complex, that can be trapped by inhibitors and results in failure of re-ligation. Attempts at new derivative designs for TopI inhibition are enthusiastically being pursued, and TopI inhibitors were developed for a variety of applications. Surface plasmon resonance (SPR) was recently used in TopI-inhibition studies.
9p
toshiba23
18-11-2011
47
2
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