Involve numerous physiological

Colorectal adenoma (CA) is an important precancerous lesion and early screening target of colorectal cancer (CRC). Lipids with numerous physiological functions are proved to be involved in the development of CRC. However, there is no lipidomic study with large-scale serum samples on diagnostic biomarkers for CA.

14p viangelamerkel 27-07-2022 6 1   Download

MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA.

11p thiencuuchu 27-11-2021 9 1   Download

Reactive oxygen species (ROS) or oxidative stress has been reported with strongly involving to pathogenesis of many diseases in human. On the other hand, ROS play a critical regulation as secondary signal to maintain intracellular redox equilibrium. Basically, the antioxidant defense systems in the body counteract with overproduced ROS. However, when the redox balance is broken under severe oxidative stress conditions, it leads to tissue injuries and numerous disorders.

6p nguyenmyhuyen90 04-03-2021 13 1   Download

Immediate early genes (IEGs) encode transcription factors which serve as first line response modules to altered conditions and mediate appropriate cell responses. The immediate early response gene EGR1 is involved in physiological adaptation of numerous different cell types.

13p vioregon2711 22-02-2021 9 2   Download

Plants are constantly exposed to stressful situations due to changing environmental conditions or through their contact with numerous pests and pathogenic microorganisms. Plants have evolved various strategies to defend themselves against these stresses. Plant responses to these stresses are complex and involve numerous physiological, molecular, and cellular adaptations.

5p angicungduoc8 07-11-2020 10 1   Download

Nuclear receptors (NRs) form a large family of ligand-inducible transcription factors that regulate gene expressions involved in numerous physiological phenomena, such as embryogenesis, homeostasis, cell growth and death.

13p vioklahoma2711 19-11-2020 6 1   Download

Antibiotic resistance and the particular emergence of multi - resistant bacterial strains are clinically relevant issue involving serious threats to public health worldwide. DNA methylation, which changes the affinity and interaction of regulatory proteins with DNA, is an epigenetic mechanism that regulates numerous bacterial physiological processes, including chromosome replication, DNA segregation, mismatch repair, transposition and transcription.

11p quenchua2 15-12-2019 6 0   Download

MicroRNAs (miRNAs) play an important role in regulating gene expression at the posttranscriptional level and are involved in numerous physiological processes. Accumulating evidence suggests that single-nucleotide polymorphisms (SNPs) in human miRNA genes may affect miRNA biogenesis pathway and influence the susceptibility to several diseases such as cancer. The present study aimed to evaluate the impact of miR-499 rs3746444, miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms on prostate cancer (PCa) risk in a sample of Iranian population.

8p kequaidan1 16-11-2019 25 2   Download

Calpains are intracellular Ca 2+ -regulated cysteine pro-teases which mediate regulatory cleavage of specific substrates. They cover a broad range of physiological functions including proteolysis of molecules involved in cytoskeletal organization, the cell cycle, signal trans-duction, apoptosis, and protein renewal during growth and tissue regeneration. Originally found in mamma-lian skeletal muscle then in numerous organisms inclu-ding protists and plants, their expression is ubiquitous [1,2].

2p inspiron33 25-03-2013 38 2   Download