Kidney cancer

Previous large observational cohort studies showed higher blood pressure (BP) positively associated with cancer. We used Mendelian randomization (MR) to obtain less confounded estimates of BP on total and sitespecific cancers.

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Gynura procumbens (Lour.) Merr. (Family: Asteraceae) is mainly popular in SouthEast Asian countries for its traditional medicinal properties. It is usually used as a traditional medicine for the treatment of eruptive fevers, rash, kidney disease, migraines, constipation, hypertension, diabetes mellitus, and cancer. It is commonly used as a traditional medicine in Vietnam for the treatment of many diseases.

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We have previously reported the Ras-dependent activation of the mitogen-activated protein kinases p44 and p42, also termed extracellular signal-regulated kinases (ERK)1 and 2 (ERK1⁄2), mediated through Gs-coupled serotonin receptors transiently expressed in human embryonic kidney (HEK) 293 cells. Whereas G i- and Gq-coupled receptors have been shown to activate Ras through the guanine nucleotide exchange factor (GEF) called Ras-GRF1 (CDC25 Mm ) by binding of Ca 2+ ⁄calmodulin to its N-terminal IQ domain, ...

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Urinary glycoproteins are important inhibitors of calcium oxalate crystal-lization and adhesion of crystals to renal cells, both of which are key mech-anisms in kidney stone formation. This has been attributed to glycosylation of the proteins. In South Africa, the black population rarely form stones (incidence

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Protein kinase Ce is expressed at higher levels in the brain compared to other tissues such as the heart and kidney, suggesting that it plays an important role in the nervous system. Several neural functions of PKCe, including neurotransmitter release and ion channel regulation, have been identified using PKCe knockout mice.

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Genome Institute of Singapore, Agency for Science, Technology and Research, 60 Biopolis Street, Singapore, 138672. †National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ‡Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4264, USA. Correspondence: Sheue-yann Cheng. E-mail: sycheng@helix.nih.gov

0p thulanh21 15-11-2011 48 2   Download

Cách đây hai ba tháng, khi Nexavar vừa được FDA approved cho metastatic cancer of the kidney: tôi liền cho ngay một bnhân bị ung thư thận (ông ta chỉ còn có 1 thận PHẢI: ung thư tìm ra ở thận TRÁI (vì thế đã cắt bỏ thận TRÁI, nhưng không kịp: ung thư ngay sau đó lên phổi: bnhân được cho Nexavar ở giai đoạn đã thấy ung thư chuyển đi lên phổi). Cách đây 3 tuần, làm lại CAT scan ở bụng, thấy thận còn lại (bên PHẢI) có dấu chứng cuả ung thư !!! và bnhân...

7p nganluong111 14-04-2011 169 3   Download

Renal and Ureteral Infections Infections of the urinary tract are common among patients whose ureteral excretion is compromised (Table 82-1). Candida, which has a predilection for the kidney, can invade either from the bloodstream or in a retrograde manner (via the ureters or bladder) in immunocompromised patients. The presence of "fungus balls" or persistent candiduria suggests invasive disease. Persistent funguria (with Aspergillus as well as Candida) should prompt a search for a nidus of infection in the kidney. Certain viruses are typically seen only in immunosuppressed patients.

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Cisplatin was discovered fortuitously by observing that bacteria present in electrolysis solutions could not divide. Only the cis diamine configuration is active as an antitumor agent. It is hypothesized that in the intracellular environment, a chloride is lost from each position, being replaced by a water molecule. The resulting positively charged species is an efficient bifunctional interactor with DNA, forming Pt-based cross-links.

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Neoplasms (See also Chap. 374) Back pain is the most common neurologic symptom in patients with systemic cancer and may be the presenting symptom. The cause is usually vertebral metastases. Metastatic carcinoma (breast, lung, prostate, thyroid, kidney, gastrointestinal tract), multiple myeloma, and non-Hodgkin's and Hodgkin's lymphomas frequently involve the spine. Cancer-related back pain tends to be constant, dull, unrelieved by rest, and worse at night. By contrast, mechanical low back pain usually improves with rest.

5p ongxaemnumber1 26-11-2010 110 6   Download