Liver tumors

Laparoscopic left lateral sectionectomy (LLLS) is indicated for liver tumors which locate in easily accessible locations (left lateral section, left lobe, ...), with small sizes,... Feasibility, safety also depend on surgeon skills, equipments. Objectives: Evaluate short-term outcomes of LLLS to treat hepatocellular carcinoma.

5p vinatisu 29-08-2024 2 1   Download

The study was performed on 25 patients diagnosed with liver tumors, assigned magnetic resonance imaging (MRI) with Primovist - a hepatospecific paramagnetic gadolinium-based contrast agent at the International Medical Center of Hue Central Hospital.

4p vinatisu 29-08-2024 3 1   Download

Intrahepatic cholangiocarcinoma (ICC) is a type of malignant tumor ranking the second in the incidence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been increasing in recent years. Small duct type of ICC has potential therapeutic targets. But overall, the prognosis of patients with ICC is usually very poor.

12p vielonmusk 21-01-2022 17 1   Download

The impact of hepatic resection for liver metastases (LM) on the survival of pediatric patients with Wilms’ tumor (WT) is unclear. So far, there is a lack of studies investigating the best suited treatment for patients with WTLM, and the role of liver resection has rarely been investigated. Thus, the development of evidence-based guide‑ lines concerning indications of liver resection for WTLM remains difficult.

16p vielonmusk 21-01-2022 13 1   Download

Hepatocellular carcinoma (HCC) is the sixth most common form of cancer worldwide. Although surgi‑ cal treatments have an acceptable cure rate, tumor recurrence is still a challenging issue. In this meta-analysis, we investigated whether statins prevent HCC recurrence following liver surgery.

9p vielonmusk 21-01-2022 14 0   Download

Certain amino acids, like glutamine and leucine, induce an anabolic response in liver. They activate p70 ribosomal protein S6 kinase (p70S6K) and acetyl-CoA carboxylase (ACC) involved in protein and fatty acids synthesis, respectively. In contrast, the AMP-activated protein kinase (AMPK), which senses the energy state of the cell and becomes activated under metabolic stress, inactivates by phosphorylation key enzymes in biosynthetic pathways thereby conserving ATP.

9p system191 01-06-2013 50 5   Download

The Department of Biochemistry and Molecular Biology, 2CREST of Japan Science and Technology Corporation; 3The Department of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, Japan We have cloned cDNA for leukotriene B4 12-hydroxydehydrogenase (LTB 4 12-HD)/15-ketoprostaglandin 13-reductase (PGR) from guinea-pig liver. LTB4 12-HD catalyzes the conversion of LTB4 into 12-keto-LTB4 in the presence of NADP1, and plays an important role in inactivating LTB4.

9p system191 01-06-2013 42 4   Download

Wilson disease (WD), an inherited disorder affecting copper metabolism, is characterized by hepatic cirrhosis and neuronal degeneration, which result from toxic levels of copper that accumulate in the liver and brain, respectively. We reported previously that the  1.3-kb promoter of the WD gene contains four metal response elements (MREs). Among the four MREs, MREa plays the most important role in the transcriptional activation of the WD promoter.

11p research12 01-06-2013 53 3   Download

We have determined the nucleotide sequence of a zebrafish cDNAclone that codes for a cellular retinol-binding protein type II (CRBPII). Radiation hybrid mapping revealed that the zebrafish and human CRBPII genes are located in syntenic groups.In situhybridization and emulsion autora-diography localized theCRBPIImRNA to the intestine and the liver of adult zebrafish.

8p research12 23-04-2013 45 4   Download

Triacylglycerols secreted by liver and carried by very low density lipoprotein (VLDL) are hydrolysed in circulation by lipoprotein and hepatic lipases. These enzymes have been shown to have positional and fatty acid specificityin vitro.If there were specificity in basal lipolysisin vivo, triacylglycerol compositionsofcirculatingandnewlysecretedVLDLwould be different. To study this we compared the composition of normal fasting VLDL triacylglycerol of Wistar rats to that obtained after blocking lipolysis by Triton WR1339, which increasedplasmaVLDL triacylglycerol concentrationabout 4.

10p tumor12 22-04-2013 33 3   Download

A Drosophila melanogaster cDNA clone (GH01916) encoding a putative 723-residue long (82 kDa) protein (CG 7415) and displaying 50% identity with mammalian cytosolic dipeptidyl aminopeptidase (DPP) III was func-tionally expressed in Schneider S2 cells. Immunocytochemi-cal studies using anti-(rat liver DPP III) Ig indicated the expression of this putative DPP III at the outer cell mem-brane and into the cytosol of transfected cells.

9p tumor12 20-04-2013 37 3   Download

Induction of CYP3A genes by the ligand-activated preg-nane-X-receptor (PXR)involves the interaction of other as yet unidentified liver transcription factors. Here we show that the CYP3A1promoter contains two active sites con-trolled by the CCAAT/enhancer-binding protein a (C/ EBPa), previously shown to regulate a number of liver stress response genes. We have identified two functional C/EBP binding sites at theCYP3A1promoter that confer luciferase activity to C/EBPacotransfected CHO cells.

9p tumor12 20-04-2013 43 4   Download

Bilitranslocase is a rat liver plasma membrane carrier, displaying a high-affinity binding site for bilirubin. It is competitively inhibited by grape anthocyanins, including aglycones and their mono- and di-glycosylated derivatives. In plant cells, anthocyanins are synthesized in the cytoplasm and then translocated into the central vacuole, by mechanisms yet to be fully characterized.

15p fptmusic 11-04-2013 30 2   Download

Exposure of blood to tissue factor (TF) rapidly initiates the coagulation serine protease cascades. TF is expressed by macrophages and other types of cell within atherosclerotic lesions and plays an important role in throm-bus formation after plaque rupture. Macrophage TF expression is induced by pro-inflammatory stimuli including lipopolysaccharide (LPS), inter-leukin-1band tumor necrosis factor-a. Here we demonstrate that activation of liver X receptors (LXRs) LXRaand LXRbsuppresses TF expression....

11p awards 06-04-2013 45 4   Download

Iron overload in the liver may occur in clinical conditions such as hemo-chromatosis and nonalcoholic steatohepatitis, and may lead to the deterior-ation of the normal liver architecture by mechanisms not well understood. Although a relationship between the expression of ICAM-1, and classical major histocompatibility complex (MHC) class I molecules, and iron over-load has been reported, no relationship has been identified between iron overload and the expression of unconventional MHC class I molecules....

14p awards 05-04-2013 32 4   Download

In order to study the role of peroxisome proliferator-acti-vated receptor ain mouse intestine, its agonist-induced proteins were identified by peptide mass fingerprinting fol-lowed byNorthern blot analysis using their cDNAs. One of the most remarkably induced proteins was identified as 17b-hydroxysterol dehydrogenase type 11. Its very rapid induction by various agonists was most efficient in intestine and then in liver.

0p awards 05-04-2013 41 2   Download

Mitochondrialb-oxidation is a complex pathway involving, in the case of saturated straight chain fatty acids of even carbonnumber, at least 16proteinswhichare organized into two functional subdomains; one associated with the inner face of the inner mitochondrial membrane and the other in the matrix. Overall, the pathway is subject to intramito-chondrial control at multiple sites. However, at least in the liver, carnitine palmitoyl transferase I exerts approximately 80% of control over pathway flux under normal conditions....

8p dell39 03-04-2013 40 2   Download

7-Ethoxy (OEt) coumarin has been used as a model substrate in many cyto-chrome P450 (P450) studies, including the use of kinetic isotope effects to probe facets of P450 kinetics. P450s 1A2 and 2E1 are known to be the major catalysts of 7-OEt coumarinO-deethylation in human liver micro-somes.

9p inspiron33 26-03-2013 53 5   Download

The conversion of UDP-glucuronate to glucuronate, usually thought to proceed by way of glucuronate 1-phosphate, is a site for short-term regula-tion of vitamin C synthesis by metyrapone and other xenobiotics in isola-ted rat hepatocytes [Linster CL & Van Schaftingen E (2003) J Biol Chem 278, 36328–36333].

12p inspiron33 26-03-2013 43 5   Download

Fatty acid-binding protein type 1 (FABP1), commonly termed liver-type fatty acid-binding protein (L-FABP), is encoded by a single gene in mam-mals. We cloned and sequenced cDNAs for two distinct FABP1s in zebra-fish coded by genes designatedfabp1a andfabp1b. The zebrafish proteins, FABP1a and FABP1b, show highest sequence identity and similarity to the human protein FABP1.

14p inspiron33 25-03-2013 39 2   Download