Low tumor grade

Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549::BRAF fusions and BRAF V600E mutations. This makes pLGG an ideal candidate for MAPK pathway-targeted treatments.

11p vikoch 27-06-2024 1 1   Download

In high-grade serous ovarian cancer (HGSOC), intrinsic and/or acquired resistance against platinumcontaining chemotherapy is a major obstacle for successful treatment. A low frequency of somatic mutations but frequent epigenetic alterations, including DNA methylation in HGSOC tumors, presents the cancer epigenome as a relevant target for innovative therapy.

15p vioraclene 31-03-2024 4 2   Download

Here, we describe a novel approach for rapid discovery of a set of tumor-specific genomic structural variants (SVs), based on a combination of low coverage cancer genome sequencing using Oxford Nanopore with an SV calling and filtering pipeline. We applied the method to tumor samples of high-grade ovarian and prostate cancer patients and validated on average ten somatic SVs per patient with breakpoint-spanning PCR mini-amplicons.

14p vibransone 28-03-2024 3 2   Download

Meningiomas are the most commonly encountered intracranial tumors, usually showing indolent behavior. Extra-axial spreading and distant metastases are seldom detected in these tumors, and lung metastasis from a low-grade meningioma is a rare event.

8p vilazada 31-01-2024 5 2   Download

Papillary thyroid carcinoma accounts for the most common type of thyroid cancer of well-differentiated type. Papillary thyroid carcinoma is featured by biologically low-grade and less aggressive tumors with a survival rate of 10 years in most of the diagnosed cases.

8p vitiki 30-01-2024 6 2   Download

Pseudomyxoma Peritonei (PMP) is a severe neoplastic clinical syndrome characterised by secretion of mucin from tumors often originating in the appendix. The standard treatment includes cytoreductive surgery (CRS) combined with heated intraperitoneal chemotherapy (HIPEC). A new perspective in PMP treatment aims at the mucins themselves as a therapeutic target.

5p vitiki 30-01-2024 3 2   Download

Dermatofbrosarcoma protuberans (DFSP) is a rare, low to intermediate-grade sarcoma, which needs imaging examination. Small series of ultrasound findings in DFSP have been published; however, the usefulness of elastography and contrast-enhanced ultrasound (CEUS) in DFSP has not been studied.

9p vileonardodavinci 23-12-2023 9 3   Download

The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is characterized by the presence of tumor-infiltrating immune cells able to modulate immune response.

10p visharma 20-10-2023 4 2   Download

Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the status and function of immune infltration in the glioma microenvironment must be explored.

18p vioracle 29-09-2023 6 3   Download

Oncocytoma is a rare salivary gland tumor consisting of oncocytes with many hyperplastic mitochondria. It usually occurs in the parotid gland. Clinical diagnosis is often challenging due to the likeness of oncocytoma to other benign and low-grade malignant salivary gland tumors.

4p viintuit 26-09-2023 2 0   Download

Neuroendocrine carcinomas (NECs) of the luminal gastrointestinal tract and pancreas are rare, poorly differentiated neoplasms. There has been difficulty identifying associated risk factors given their very low incidence. Here we present three cases of NEC diagnosed in an 8-month period in a Minneapolis safety-net hospital.

3p viintuit 26-09-2023 1 0   Download

Solid pseudopapillary tumors (SPTs) of the pancreas is a low-grade malignant tumor, accounting for only 1–2.5% of all pancreatic tumors. In particular, small (≤ 3 cm) SPTs do not often have typical computed tomography (CT) features, making them easily misdiagnosed with other solid tumors and eventually affecting the choice of treatment method.

5p vigamora 23-05-2023 8 3   Download

Rectal neuroendocrine neoplasms are rare epithelial neoplasms of the rectum. The incidence of these tumors has increased over the past decades. However, many questions remain unanswered regarding their clinicopathology, including the possible mechanisms in which these tumors may grow and metastasize.

9p vidoctorstrange 06-05-2023 5 2   Download

Low-grade glioma (LGG) is susceptible to ferroptosis, which is involved in TMZ resistance. Ferroptosis induction can enhance the sensitivity to TMZ and synergistically kill glioma cells. T cell-promoted tumor ferroptosis is a vital anti-tumor mechanism of immune checkpoint inhibitors.

15p viangelamerkel 27-07-2022 6 1   Download

While lymphadenectomy of metastatic lymph nodes (LNs) has been associated with improved outcome, the clinical utility of prophylactic lymphadenectomy in dogs with stage I cutaneous mast cell tumors (cMCTs) remains a controversial topic.

10p vidarwin 22-02-2022 10 1   Download

There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and lowgrade UTUC after tumor resection, and to explore the difference between high- and low-grade patients.

16p vimahuateng 26-11-2021 7 1   Download

The differential diagnosis of endometrial stromal tumor (EST) and uterine cellular leiomyoma (CL) remains a challenge in clinical practice, especially low grade endometrial stromal sarcoma (ESS) and CL, suggesting the need for novel immunomarkers panels for differential diagnosis.

9p vimahuateng 26-11-2021 8 1   Download

The heterogeneous subtypes and stages of epithelial ovarian cancer (EOC) differ in their biological features, invasiveness, and response to chemotherapy, but the transcriptional regulators causing their differences remain nebulous.

18p vimahuateng 26-11-2021 8 1   Download

The aim of this study is to explore the clinicopathological significance, prognostic value and immune signature of TYROBP expression in lowgrade glioma (LGG). It is dysregulated in various malignancies, although little is known regarding its role in low-grade glioma.

14p vimahuateng 26-11-2021 10 1   Download

Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in numerous tumors or diseases including glioma.

10p vimahuateng 26-11-2021 7 1   Download