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Mammalian health
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Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system.
16p
vibransone
28-03-2024
2
1
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Part 1 book "Cardiac electrophysiology, from cell to bedside" includes content: Voltage gated sodium channels and electrical excitability of the heart, voltage regulated potassium channels, structural and molecular bases of cardiac inward rectifier potassium channel function, mammalian calcium pumps in health and disease,... and other contents.
487p
oursky06
13-10-2023
5
1
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Wild aquatic birds serve as the natural reservoir for avian influenza virus (AIV), a disease with significant implications for avian and mammalian health. Climate change is predicted to impact the dynamics of AIV, particularly in areas such as the Arctic, but the baseline data needed to detect these shifts is often unavailable. In this study, plasma from two species of gulls breeding on the high-Arctic Svalbard archipelago were screened for antibodies to AIV.
4p
vigalileogalilei
28-02-2022
13
1
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Mammals have wide variations in testicular position, with scrotal testes in some species and ascrotal testes in others. Although cryptorchidism is hazardous to human health, some mammalian taxa are natural cryptorchids. However, the evolution of testicular position and the molecular mechanisms underlying the maintenance of health, including reproductive health, in ascrotal mammals are not clear.
13p
vilarryellison
29-10-2021
6
1
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Akkermansia muciniphila is one of the most dominant bacteria that resides on the mucus layer of intestinal tract and plays key role in human health, however, little is known about its genomic content.
12p
vilarryellison
29-10-2021
11
1
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Each year, influenza is responsible for hundreds of thousand cases of illness and deaths worldwide. Due to the virus’ fast mutation rate, the World Health Organization (WHO) is constantly on alert to rapidly respond to emerging pandemic strains.
12p
viuchiha2711
21-04-2020
10
0
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Due to their rising incidence and progressive geographical spread, infections with mosquito-borne viruses, such as dengue (DENV), chikungunya and zika virus, have developed into major public health challenges.
11p
vihamax2711
21-04-2020
10
0
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Cytosine methylation at the 5-carbon position is the only known stable base modification found in the mammalian genome. The organization and modification of chromatin is a key factor in programming gene expression patterns. Recent findings suggest that DNA methylation at the junction of transcription initiation and elongation plays a critical role in suppression of transcription.
22p
vinaphone15
28-02-2013
39
2
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The small leucine-rich proteoglycans (SLRPs) are involved in many aspects of mammalian biology, both in health and disease. They are now being rec- ognized as key signaling molecules with an expanding repertoire of molecu- lar interactions affecting not only growth factors, but also various receptors involved in controlling cell growth, morphogenesis and immunity.
12p
viettel02
19-02-2013
44
2
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The mammalian natriuretic peptide system, consisting of at least three ligands and three receptors, plays critical roles in health and disease. Exam-ination of genetically engineered animal models has suggested the signifi-cance of the natriuretic peptide system in cardiovascular, renal and skeletal homeostasis.
12p
cosis54
05-01-2013
42
3
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The total number of mammalian cortical granule proteins has been estimated to be between four and fourteen or more [10,19,20]. Several specific proteins have been iden- tified as cortical granule proteins [21]. N-acetylglucosami- nidase was detected in exudates of ionophore-activated mouse oocytes using an enzymatic assay and was local- ized in the cortical granules at the electron microscopic level [13].
10p
ut_hai_can
25-12-2012
33
3
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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the horizon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions,whichweremedically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the first generation of protein therapeutics was produced in recombinant Escherichia coli, most recent products usemammalian cells as production hosts.Not long after the first production of recombinant proteins in E.
179p
codoc_pn87
24-11-2012
59
10
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PART 3 Further issues and future prospects © 2001 C. H. Walker CHAPTER 13 The ecotoxicological effects of herbicides 13.1 Introduction Chapters 5–12 deal with groups of pollutants that have been studied in some depth and detail, largely because they have appreciable – sometimes very high – mammalian toxicity and are perceived as human health hazards. Some of them are markedly persistent and undergo biomagnification with passage along food chains.
9p
bengoan741
24-12-2011
65
7
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It is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to the proteolytic activity of trypsin, cell surface proteins are often cleaved, which leads to dysregulation of the cell functions. Methods: In this study, a triplicate 2D-DIGE strategy has been performed to monitor trypsin-induced proteome alterations. The differentially expressed spots were identified by MALDI-TOF MS and validated by...
10p
toshiba23
18-11-2011
58
2
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The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S. Both isoforms function as bridge molecules to assemble their partners together to regulate their target genes. A typical LMO2 binding site consists of two elements, a GATA site and an E-box, with an interval of 9~12 bp. Methods: In this study, the combination of MBP pulldown assay and mammalian two hybrid assay were...
10p
toshiba23
18-11-2011
44
4
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