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Mammalian mitochondrial genome
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Mitochondria are organelles that fulfill a fundamental role in cell bioenergetics, as well as in other processes like cell signaling and death. Small non-coding RNAs (sncRNA) are now being considered as pivotal posttranscriptional regulators, widening the landscape of their diversity and functions. In mammalian cells, small RNAs encoded by the mitochondrial genome, mitosRNAs were discovered recently, although their biological role remains uncertain.
12p
vitzuyu2711
29-09-2021
12
1
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Although animal mitochondrial DNA sequences are known to evolve rapidly, their gene arrangements often remain unchanged over long periods of evolutionary time. Therefore, comparisons of mitochondrial genomes may result in significant insights into the evolution both of organisms and of genomes.
8p
vigiselle2711
30-08-2021
13
1
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Despite the likely requirement for a DNA topoisomerase II activity during synthesis of mitochondrial DNA in mam-mals, this activity has been very difficult to identify convin-cingly.TheonlyDNAtopoisomerase II activity conclusively demonstrated to be mitochondrial in origin is that of a type II activity found associated with the mitochondrial, kineto-plast DNAnetwork in trypanosomatid protozoa [Melendy, T., Sheline, C., and Ray, D.S. (1988)Cell55, 1083–1088; Shapiro, T.A.,Klein,V.A., andEnglund, P.A. (1989)J.Biol. Chem.264, 4173–4178]....
14p
tumor12
20-04-2013
24
1
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Termination of mitochondrial (mt) H-strand transcription in mammalian cells occurs at two distinct sites on the genome. The first site of termination, referred to as mt-TERM occurs beyond the 16 S rRNA gene. However, the second and final site of termination beyond the tRNA Thr gene remains unclear. In this study we have characterized the site of termination of the polycistronic distal gene transcript beyond the D-loop region, immedi-ately upstream of the tRNA Phe gene.
13p
tumor12
20-04-2013
39
2
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The ESSS protein is a recently identified subunit of mam-malian mitochondrial complex I. It is a relatively small integral membrane protein (122 amino acids) found in the b-subcomplex. Genomic sequence database searches reveal its localization to theX-chromosome inhumans andmouse. TheESSScDNAfromChinesehamster cellswas clonedand shown to complement one complementation group of our previously described mutants with a proposed X-linkage. Sequence analyses of the ESSS cDNA in these mutants revealed chain termination mutations. ...
9p
awards
05-04-2013
32
3
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