Báo cáo khoa học: A truncated form of DNA topoisomerase IIb associates with the mtDNA genome in mammalian mitochondria
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Despite the likely requirement for a DNA topoisomerase II activity during synthesis of mitochondrial DNA in mam-mals, this activity has been very difficult to identify convin-cingly.TheonlyDNAtopoisomerase II activity conclusively demonstrated to be mitochondrial in origin is that of a type II activity found associated with the mitochondrial, kineto-plast DNAnetwork in trypanosomatid protozoa [Melendy, T., Sheline, C., and Ray, D.S. (1988)Cell55, 1083–1088; Shapiro, T.A.,Klein,V.A., andEnglund, P.A. (1989)J.Biol. Chem.264, 4173–4178]....
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