Mammary gland development

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  • Identification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.

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  • The mammary gland develops through several distinct stages. The first transpires in the embryo as the ectoderm forms a mammary line that resolves into placodes which leads to various stages like mammary bud, primary sprout, secondary and tertiary sprouts. Simultaneously the connective tissue whorls, fat pad, teat and gland sinus and other associated structures like sweat and sebaceous glands are also developed. Regulated by epithelial/mesenchymal interactions, the placodes descend into the underlying mesenchyme and produce the ductal structure of the gland present at birth.

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  • Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers. Activated Wnt signaling leads to inappropriate mammary gland development and mammary tumorigenesis in mice.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Genomic analysis of early murine mammary gland development using novel probe-level algorithms...

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  • Data from in vivo and in vitro studies suggest that activation of Akt regulates cell survival signaling and plays a key role in tumorigenesis. Hence, transgenic mice were created to explore the oncogenic role of Akt1 in the development of mammary tumors.

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  • Steroid hormone receptors are important drug targets and have been the focus of basic and applied research for decades. Steroid hormone receptors act as ligand-dependent transcription factors. Upon ligand binding, the receptors bind to hormone responsive cis-acting DNA elements (HREs) in the nucleus and regulate the expression of target genes by recruiting chromatin-modifying activities that either promote or deny access to the basal transcription machinery.

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  • part 1 book “breast cancer - diagnostic imaging and therapeutic guidance” has contents: development, anatomy, and physiology of the mammary gland, tumor formation, pathology of benign and malignant changes in the breast, nonimaging diagnostics, mammography,.. and other contents.

    pdf125p tieu_vu14 15-08-2018 9 0   Download

  • (bq) part 1 book “breast cancer - diagnostic imaging and therapeutic guidance” has contents: development, anatomy, and physiology of the mammary gland, tumor formation, pathology of benign and malignant changes in the breast, nonimaging diagnostics, breast ultrasonography,… and other contents.

    pdf125p tieu_vu15 07-09-2018 13 0   Download

  • The objective of this study was to explore the gross morphological and histolmorphometric observations in the mammary gland of Boer graded local goats in India. The present study was conducted in adult lactating and nonlactating (n =6 each) Boer local she-goats. The mammary gland in both the group was a compound tubulo-alveolar gland surrounded by a connective tissue capsule. The alveoli were the principal secretory unit lined by simple cuboidal epithelium. In lactating animals, well developed alveoli, filled with secretions and lipid droplets were observed.

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  • The serine-threonine kinase AKT1 plays essential roles during normal mammary gland development as well as the initiation and progression of breast cancer. AKT1 is generally considered a ubiquitously expressed gene, and its persistent activation is transcriptionally controlled by regulatory elements characteristic of housekeeping gene promoters.

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  • The applications of multiphoton microscopy for deep tissue imaging in basic and clinical research are ever increasing, supplementing confocal imaging of the surface layers of cells in tissue. However, imaging living tissue is made difficult by the light scattering properties of the tissue, and this is extraordinarily apparent in the mouse mammary gland which contains a stroma filled with fat cells surrounding the ductal epithelium.

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  • A similar effort may well be in order targeting the gay and bisexual men who are most at risk, particularly those who are living with HIV. Further research is needed to determine the prevalence and incidence of ASIL in the general population of gay and bisexual men outside of major urban centers. Programs are needed to train colposcopists in the skills of identifying and biopsying ASIL; training of colorectal surgeons is needed to optimize identification and treat- ment of ASIL.

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  • Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen receptor dictates their possible contributing role in mammary gland development and disease.

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  • Deleted in Liver Cancer 1 (Dlc1) is a tumor suppressor gene, which maps to human chromosome 8p21-22 and is found frequently deleted in many cancers including breast cancer. The promoter of the remaining allele is often found methylated.

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  • Milk evolved as a means of providing for the postnatal needs of the developing mammalian neonate. Any perception that milk is a simple, homogeneous fluid does not adequately acknowledge the remarkable array of complex activities and functionalities of its constituent components.

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  • A four years age cow was presented to the Veterinary Clinical Complex (VCC), College of Veterinary Science, Rajendranagar, Hyderabad with the history of decreased appetite, depression, decreased milk yield and with swollen mammary gland for four days. General clinical examination revealed increased body temperature of 1040 F and palpation of udder revealed swollen udder and animal is feeling pain on touch. Milk was stripped for testing and found flakes and the colour of the milk is yellowish brown.

    pdf6p caygaocaolon6 30-07-2020 0 0   Download



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