Mechanical resistance

5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.

16p vishanshan 27-06-2024 2 1   Download

High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response and a drug resistance mechanism.

12p vishanshan 27-06-2024 1 1   Download

Part 2 of ebook "Reinforced concrete: Mechanics and design (Sixth edition)" provides readers with contents including: Chapter 12 - Slender columns; Chapter 13 - Two-way slabs behavior, analysis, and design; Chapter 14 - Two-way slabs elastic and yield-line analyses; Chapter 15 - Footings; Chapter 16 - Shear friction, horizontal shear transfer, and composite concrete beams; Chapter 17 - Discontinuity regions and strut-and-tie models; Chapter 18 - Walls and shear walls; Chapter 19 - Design for earthquake resistance;...

597p mothoiphong 28-06-2024 1 1   Download

This study aimed to explore the effect of CD276 expression on the sunitinib sensitivity of clear cell renal cell carcinoma (ccRCC) cell and animal models and the potential mechanisms involved.

15p vikoch 27-06-2024 1 1   Download

Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitro and in vivo.

14p vikoch 27-06-2024 1 1   Download

High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting.

18p vikoch 27-06-2024 1 1   Download

Water-borne acrylic resin has attracted much attention thanks to its environmetally friendly, high weather stability, good mechanical properties, high toughness. It is widely used in coatings, ships, bridges, locomotives, etc.

10p viamancio 04-06-2024 0 0   Download

The paper "The behavior analysis of bolted end-plate connections under static load by using finite element method" investigates the mechanical behavior of bolted end-plate beam-to- column connections with changes of thin of end-plate and size of bolts under bending moment. The finite element models are generated in ANSYS software, in specially all of meshes are hexahedral meshes as well as be continuous at welding. The results obtained from this study are validated based on three factors: loading capacity, moment resistance and joint rotation.

9p dathienlang1012 03-05-2024 2 0   Download

This study investigated the effect of graphene content on intumescent coating properties. Intumescent coatings contained Plextol R4152 as a binder, APP-PER-MEL as a flame retardant additive system, TiO2, Al(OH)3 as fillers, and other additive. The fire resistance test and furnace test were conducted. TGA, DSC, and SEM were used to assess the coating and char layers. The water resistance and mechanical properties of the coatings were examined.

12p dianmotminh02 03-05-2024 2 1   Download

In conclusion, sequence analysis may be useful for the rapid detection of STR resistance in MDR M. tuberculosis strains, which in turn could contribute to better control strategies of TB in Vietnam. Other molecular mechanisms associated with STR resistance in STR-resistant strains without mutations in the rpsL and rrs genes need to be further investigated.

11p dianmotminh02 03-05-2024 3 1   Download

The obtained results showed that the coating at the spray current of 300 A, the air pressure of 5.5 bar and the stand-off distance of 162.8 mm has the lowest porosity and highest microhardness. In addition, this coating also has better adhesion to the steel substrate and wear resistance than other coatings. Moreover, X–ray phase analysis showed that the following phases are created on the surface of the Al-Mg coatings: Al, Al2MgO4 and Al3Mg2.

7p dianmotminh02 03-05-2024 2 1   Download

Part 1 book "Review of medical microbiology and immunology" includes content: Bacteria compared with other microorganisms; structure of bacterial cells; growth; genetics; classification of medically important bacteria; normal flora; pathogenesis; host defenses; laboratory diagnosis; antimicrobial drugs - mechanism of action; antimicrobial drugs - resistance; bacterial vaccines; sterilization & disinfection.

419p zizaybay1101 30-04-2024 3 2   Download

Ebook "Targeted therapies in cancer: Myth or Reality?" contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures.

200p ladongphongthanh1008 22-04-2024 7 1   Download

Ebook "Mechanisms of insulin action" will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.

223p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Self and nonself" focuses on the origin of the immune response during the development of multicellularity (Chapters 1-4). Bacteria have developed defense systems against viruses and conversely, viruses have devised escape mechanisms that allow infection. Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity known as the CRISPR-Cas, that confers resistance to mobile genetic elements.

338p tracanhphuonghoa1007 22-04-2024 1 1   Download

Ebook "Fungal biofilms and related infections: Advances in microbiology, infectious diseases and public health (Volume 3)" covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections.

129p tracanhphuonghoa1007 22-04-2024 7 2   Download

Ebook "The long and short noncoding RNAs in cancer biology" conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance).

455p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Thermal treatments of canned foods" describes the chemical features of canned food products and gives background information on the technology of canning foods. It explains how canned foods are different from other packaged foods, and illustrates and discusses their unique properties, including risks and failures. Canned foods are usually considered to offer a particularly long shelf-life and durability.

58p tracanhphuonghoa1007 22-04-2024 7 2   Download

In this article, the effect of modified nanosilica (m-nanosilica) on the mechanical and creep performance of epoxy resin were investigated. At the same time, the toughnening mechanisms of epoxy resin with m-nanosilica were also considered.

13p viohoyo 25-04-2024 4 2   Download

Part 2 book "Electromagnetic, mechanical and transport properties of composite materials" includes content: Viscoelastic behavior of composites; general introduction to heat transfer; fundamentals of conductive heat transfer; thermal conductivity of composites; thermal conductivity of composites of core shell particles; influence of interfacial contact resistance on thermal conductivity of composites; thermal diffusivity and coefficient of thermal expansion of composites;... and other contents.

203p dianmotminh00 22-04-2024 5 1   Download