Medical condition

Temporomandibular disorders (TMD) are a common medical condition in Vietnam and around the world. Fonseca Anamnestic Index (FAI) is a quick and simple questionnaire to diagnose TMD. Objectives: (1) To evaluate the accuracy and reliability of FAI in the diagnosis of TMD and (2) to suggest adjustments to enhance the clinical value of FAI.

8p viharuno 03-01-2025 1 1   Download

The core list presents a list of minimum medicine needs for a basic health‐care system, listing the most efficacious, safe and cost‐effective medicines for priority conditions. Priority conditions are selected on the basis of current and estimated future public health relevance, and potential for safe and cost‐effective treatment. The complementary list presents essential medicines for priority diseases, for which specialized diagnostic or monitoring facilities, and/or specialist medical care, and/or specialist training are needed.

45p kikyou751998 23-05-2012 444 38   Download

Several 1985-7 deaths of cancer patients were due to overdoses of radiation resulting from a race condition between concurrent tasks in the Therac-25 software. Errors in medical software have caused deaths. Details in B.W. Boehm, "Software and its Impact: A Quantitative Assessment," Datamation,19(5), 48-59(1973). cần kinh nghiệm khiểm thử, một vài sự hiểu biệt về các pha phát triển của dự án co1 thể có ích, toán học có thể trợ giúp

31p phongk2t1 20-12-2010 307 78   Download

Normally, any ferromagnetic or ferrimagnetic material undergoes a transition to a paramagnetic state above its Curie temperature. Superparamagnetism is different from this standard transition since it occurs below the Curie temperature of the material. Superparamagnetism occurs in nanoparticles which are single domain. This is possible when their diameter is below 3–50 nm, depending on the materials.

33p thinh3m 28-03-2013 59 4   Download

This research project aimed to: (a) determine the demographic profile and common conditions of patients in a Teaching Clinic; (b) describe the adverse events from Chinese medicine treatment; (c) examine the overall treatment outcomes and treatment interventions of Chinese medicine in patients with respiratory disorders; and (d) assess the level of knowledge and compliance with Chinese medicine in patients with respiratory disorders.

304p runthenight07 01-03-2023 9 3   Download

Document "Constipation: A global perspective" introduction of content: Cascades—a resource-sensitive approach, pathogenesis and risk factors, associated conditions and medication, diagnostic criteria for functional constipation, patient evaluation,... Invite you to consult.

13p vovanvovan2013 13-05-2016 37 2   Download

Certain amino acids, like glutamine and leucine, induce an anabolic response in liver. They activate p70 ribosomal protein S6 kinase (p70S6K) and acetyl-CoA carboxylase (ACC) involved in protein and fatty acids synthesis, respectively. In contrast, the AMP-activated protein kinase (AMPK), which senses the energy state of the cell and becomes activated under metabolic stress, inactivates by phosphorylation key enzymes in biosynthetic pathways thereby conserving ATP.

9p system191 01-06-2013 50 5   Download

Protein refolding is currently a fundamental problem in biophysics and molecular biology. We have studied the refolding process of frutalin, a tetrameric lectin that presents structural homology with jacalin but shows a more marked biological activity. The initial state in our refolding puzzle was that proteins were unfolded after thermal denaturation or denaturation induced by guanidine hydrochloride, and under both conditions, frutalin was refolded.

6p research12 01-06-2013 43 4   Download

Bovineb-lactoglobulin was hydrolyzed with trypsin or chymotrypsin in the course of heat treatment at 55, 60 and 65°C at neutral pH. At these temperaturesb-lactoglobulin undergoes signi®cant but reversible structural changes. In the conditions used in the present study,b-lactoglobulinwas virtually insensitive to proteolysis by either enzyme at room temperature, but underwent extensive proteolysis when either proteasewas present during the heat treatment.

11p research12 29-04-2013 33 3   Download

The cAMP-dependent protein kinase (PKA) signaling pathway plays a major role in a number of pathophysio-logical conditions. However, there have been conflicting evidences regarding the action of cAMP/PKA on nuclear factor-jB(NF-jB). Inthis study,wehaveexplored the effect of cAMP/PKA on NF-jBactivity and determined its molecular mechanism. PKA activating agents or expression of thecatalyticsubunitofPKA(PKAc) inhibitedtheNF-jB-dependent reporter gene expression induced by tumor nec-rosis factora(TNFa). ...

7p research12 23-04-2013 33 4   Download

To examine whether valinomycin induces a mitochondrial permeability transition (PT), we investigated its effects on mitochondrial functions under various conditions. The acceleration of mitochondrial respiration and swelling, induced by valinomycin, were found to be insensitive to inhibitors of the ordinary PT, indicating that valinomycin does not induce the ordinary PT. Results of experiments usingmitochondria isolated fromtransgenicmice expressing human bcl-2 also supported this conclusion.

7p tumor12 22-04-2013 35 3   Download

Acomputational approach is used to analyse temporal gene expression in the context of metabolic regulation. It is based on the assumption that cells developed optimal adaptation strategies to changing environmental conditions. Time-dependent enzyme profiles are calculatedwhichoptimize the function of a metabolic pathway under the constraint of limited total enzymeamount.For linearmodel pathways it is shown thatwave-like enzyme profiles are optimal for a rapid substrate turnover.

8p tumor12 22-04-2013 49 3   Download

The transcription factor v-Myb is a potent inducer of myeloid leukemias, and its cellular homologue c-Myb plays a crucial role in the regulation of hematopoiesis. Recently, Bies and coworkers (Bies, J., Markus, J. & Wolff, L. (2002)J. Biol. Chem, 277, 8999–9009) presented evidence that murine c-Myb can be sumoylated under overexpression conditions in COS7 cells when cotrans-fected with FLAG-tagged SUMO-1.

11p tumor12 20-04-2013 38 3   Download

UMP-CMP kinase catalyses an important step in the phosphorylationofUTP, CTPanddCTP. It is also involved in the necessary phosphorylation by cellular kinases of nucleoside analogs used in antiviral therapies. The reactivity of human UMP-CMP kinase towards natural substrates and nucleotide analogs was reexamined. The expression of the recombinant enzyme and conditions for stability of the enzyme were improved. Substrate inhibition was observed for UMP and CMP at concentrations higher than 0.2 mM, but not for dCMP.

7p fptmusic 16-04-2013 37 3   Download

A new baculovirus-based fluorescence resonance energy transfer (Bv-FRET) assay for measuringmultimerization of cell surface molecules in living cells is described. It has been demonstrated that gonadotropin-releasing hormone recep-tor (GnRH-R) was capable of forming oligomeric com-plexes in the plasma membrane under normal physiological conditions. The mouse gonadotropin-releasing hormone receptor GnRH-R was used to evaluate the efficiency and potential applications of this assay.

9p fptmusic 12-04-2013 58 4   Download

The heat- and pressure-induced unfolding of the glycosyl-ated and unglycosylated forms of mature carboxypeptidase Y and the precursor procarboxypeptidase Y were analysed by differential scanning calorimetry and/or by their intrinsic fluorescence in the temperature range of 20–75
Corthe pressure range of 0.1–700 MPa. Under all conditions, the precursor form showed a clear two-state transition from a folded to an unfolded state, regardless of the presence of the carbohydrate moiety.

7p fptmusic 12-04-2013 53 2   Download

Catalytic antibodies capable of digesting crucial proteins of pathogenic bac-teria have long been sought for potential therapeutic use. Helicobacter pyloriurease plays a crucial role for the survival of this bacterium in the highly acidic conditions of human stomach. The HpU-9 monoclonal anti-body (mAb) raised againstH. pyloriurease recognized thea-subunit of the urease, but only slightly recognized theb-subunit. However, when isolated both the light and the heavy chains of this antibody were mostly bound to the b-subunit....

9p fptmusic 11-04-2013 45 3   Download

In eukaryotes, pre-rRNA processing depends on a large number of non-ribosomal trans-acting factors that form large and intriguingly organized complexes. A novel nucleolar protein, Nop53p, was isolated by using Nop17p as bait in the yeast two-hybrid system. Nop53p also interacts with a second nucleolar protein, Nip7p. A carbon source-conditional strain with the NOP53coding sequence under the control of theGAL1promoter did not grow in glucose-containing medium, showing the phenotype of an essential gene. ...

14p fptmusic 11-04-2013 32 2   Download

There is still a controversy over the mechanism of promoter DNA strand separation upon open transcription complex (RPo) formation by Escheri-chia coli RNA polymerase: is it a single or a stepwise process controlled by Mg 2+ ions and temperature? To resolve this question, the kinetics of pseudo-first-order oxidation of thymine residues by KMnO4 in the )11…+2 DNA region of RPo at thekPRpromoter was examined under single-hit conditions as a function of temperature (13–37
C) in the absence or presence of 10 mmMgCl2....

16p awards 06-04-2013 45 2   Download

Botulinum neurotoxin type A (BoNT⁄A), the most toxic substance known to mankind, is produced by Clostridium botulinumtype A as a complex with a group of neurotoxin-associated proteins (NAPs) through polycis-tronic expression of a clustered group of genes. NAPs are known to protect BoNT against adverse environmental conditions and proteolytic digestion. Hemagglutinin-33 (Hn-33) is a 33 kDa subcomponent of NAPs that is resistant to protease digestion, a feature likely to be involved in the protec-tion of the botulinum neurotoxin from proteolysis. ...

10p awards 06-04-2013 33 3   Download