Melanoma cell lines

The formation of blood vessels within solid tumors directly contributes to cancer growth and metastasis. Until recently, tumor vasculature was thought to occur exclusively via endothelial cell (EC) lined structures (i.e. angiogenesis), but a second source of tumor vasculature arises from the cancer cells themselves, a process known as vasculogenic mimicry (VM).

14p vimahuateng 26-11-2021 7 1   Download

The PI 3-kinase (PI3K) pathway has been implicated as a target for melanoma therapy. Methods: Given the high degree of genetic heterogeneity in melanoma, we sought to understand the breadth of variation in PI3K signalling in the large NZM panel of early passage cell lines developed from metastatic melanomas.

12p vianrose2711 27-04-2021 8 1   Download

This study demonstrated that high transcript expression levels of ZFP-280D in melanocytes and in benign tumors of 304 Ret mice, a transgenic mouse line in which a systemic skin melanosis, benign melanocytic tumors and malignant melanoma which develop stepwise were inhibited in melanoma cell lines (human and murine) and in the malignant melanoma of 304 Ret mice.

7p tamynhan9 02-12-2020 12 2   Download

Conventional therapeutic agents are largely unsatisfactory into the treatment of malignant melanoma. Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most prevalent alteration in melanoma patients) appears very promising from the clinical point of view.

3p vijisoo2711 29-09-2020 16 1   Download

Chemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesion and survival.

14p virose2711 25-09-2020 14 1   Download

The nerve growth factor (NGF) receptor tyrosine-kinase TrkA is a well-known determinant of the melanocytic lineage, through modulation of the MAPK and AKT cascades. While TrkA gene is frequently rearranged in cancers, its involvement in malignant melanoma (MM) development is still unclear.

18p vimoscow2711 29-08-2020 15 2   Download

We have previously demonstrated that the hydroxylated biphenyl compound D6 (3E,3′E) -4,4′-(5,5′,6,6′-tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)bis(but-3-en-2-one), a structural analogue of curcumin, exerts a strong antitumor activity on melanoma cells both in vitro and in vivo.

11p vinaypyidaw2711 26-08-2020 16 3   Download

Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas.

13p vidhaka2711 31-07-2020 12 1   Download

More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncontrolled cell growth.

10p vibaku2711 22-07-2020 15 2   Download

Metastatic melanoma is an aggressive form of skin cancer that evades various anti-cancer treatments including surgery, radio-,immuno- and chemo-therapy. TRAIL-induced apoptosis is a desirable method to treat melanoma since, unlike other treatments, it does not harm non-cancerous cells.

13p vimanila2711 29-06-2020 31 1   Download

Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis.

16p viputrajaya2711 22-06-2020 10 0   Download

Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel™ is an extract which has been demonstrated with experimental data that displays anticancer activity.

6p vienzym2711 03-04-2020 14 2   Download

Increased levels of calprotectin subunits S100A8 and S100A9 have been detected in human cancers. Melanoma is the most aggressive type of skin cancer, and its treatment is challenging because of its brain metastasis.

8p nutifooddau 27-01-2019 32 1   Download

A series of alpha-substituted 2’,5’-dihydroxychalcones bearing a cyanide, bromine, or methyl group at alpha-position were synthesized and evaluated for in vitro cytotoxicity against three cancer cell lines, including B16, murine melanoma, HCT116 (colon cancer), A431 (human epidermoid carcinoma), and HUVEC (human umbilical venous endothelial cell). The synthesized chalcones showed significant cytotoxicity against most of cell lines, with IC50 values ranging from 0.97 to 10 µg/mL.

6p uocvong04 24-09-2015 38 3   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

13p dauphong8 14-01-2012 32 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

13p dauphong6 04-01-2012 61 8   Download

Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma

11p dauphong4 03-01-2012 43 3   Download

Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032

11p dauphong4 03-01-2012 30 3   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines

11p dauphong3 03-01-2012 51 2   Download