Down regulation of zinc finger protein 280D (ZFD 280D)

This study demonstrated that high transcript expression levels of ZFP-280D in melanocytes and in benign tumors of 304 Ret mice, a transgenic mouse line in which a systemic skin melanosis, benign melanocytic tumors and malignant melanoma which develop stepwise were inhibited in melanoma cell lines (human and murine) and in the malignant melanoma of 304 Ret mice.