![](images/graphics/blank.gif)
Membrane fusion
-
In ebook "Caveolins and caveolae: Roles in signaling and disease mechanisms" caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae.
199p
ladongphongthanh1008
22-04-2024
5
2
Download
-
Ebook "Mitochondria and cell death" examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity.
242p
tracanhphuonghoa1007
22-04-2024
2
2
Download
-
Ebook "Viral entry into host cells" for a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism.
213p
cotieubac1004
15-03-2024
1
0
Download
-
Vacuolar protein sorting-associated protein 4B (VPS4B) is a member of the ATP enzyme AAA protein family, and is mainly involved in protein degradation and cell membrane fusion. Recently, a dominant mutation in this gene was identified in human dentin dysplasia type I (DD-I).
10p
vihagrid
30-01-2023
6
3
Download
-
SNAP-25 protein is contributory to plasma membrane and synaptic vesicle fusions that are critical points in neurotransmission. SNAP-25 gene is associated with behavioral symptoms, personality and psychological disorders. In addition, SNAP-25 protein can be related to different neurotransmitter functions due to its association with vesicle membrane transition and fusion.
5p
viannito2711
20-04-2021
11
1
Download
-
Dysferlinopathies are a group of muscle disorders causing muscle weakness and absence or low levels of dysferlin, a type-II transmembrane protein and the causative gene of these dystrophies. Dysferlin is implicated in vesicle fusion, trafficking, and membrane repair.
10p
vimariana2711
22-12-2020
7
1
Download
-
Influenza A viruses possess RNA genomes that mutate frequently in response to immune pressures. The mutations in the hemagglutinin genes are particularly significant, as the hemagglutinin proteins mediate attachment and fusion to host cells, thereby influencing viral pathogenicity and species specificity.
7p
viwyoming2711
16-12-2020
9
1
Download
-
The importance of the material properties of membranes for diverse cellular processes is well established. Notably, the elastic properties of the membrane, which depend on its composition, can directly influence membrane reshaping and fusion processes as well as the organisation and function of membrane proteins.
11p
vioklahoma2711
19-11-2020
13
3
Download
-
Characterizing membrane dynamics is a key issue to understand cell exchanges with the extra-cellular medium. Total internal reflection fluorescence microscopy (TIRFM) is well suited to focus on the late steps of exocytosis at the plasma membrane.
10p
viflorida2711
30-10-2020
18
1
Download
-
Spanins are phage lysis proteins required to disrupt the outer membrane. Phages employ either twocomponent spanins or unimolecular spanins in this final step of Gram-negative host lysis.
26p
viconnecticut2711
28-10-2020
17
1
Download
-
Bovine herpesvirus-1 (BHV-1) a member of the Herpes viridae family and Alphaherpes viridae subfamily genus Varicello virus is a most common viral pathogen found in bovine semen. The entry process of Alphaherpes viruses consist of two steps, initial virus attachment and subsequent virus penetration involving membrane fusion as in other alphaherpes viruses, BHV-1 glycoproteins are the major structural components of the viral envelope and virus-infected cell membranes.
10p
angicungduoc5
12-06-2020
14
2
Download
-
The OsSec18 complex interacts with P0(P1-P2)2 to regulate vacuolar morphology in rice endosperm cell
Sec18p/N-ethylmaleimide-sensitive factor (NSF) is a conserved eukaryotic ATPase, which primarily functions in vesicle membrane fusion from yeast to human. However, the function of the OsSec18 gene, a homologue of NSF in rice, remains unknown.
9p
viminato2711
22-05-2020
12
1
Download
-
Hybridomas are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, Bcells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow indefinitely in culture (myeloma is a B-cell cancer). This fusion is performed by making the cell membranes more permeable. The fused hybrid cells (called hybridomas), being cancer cells, will multiply rapidly and indefinitely and will produce large amounts of the desired antibodies.
7p
zingzing09
24-04-2013
68
4
Download
-
The N-terminal fusion peptide of Sendai virus F1envelope glycoprotein is a stretchof 14aminoacids,most ofwhichare hydrophobic. Following this region, we detected a segment of 11 residues that are strikingly similar to the N-terminal fusion peptide. We found that, when anchored to the mem-brane by palmitoylation of its N-terminus, this segment (WT-palm-19–33) induces membrane fusion of large unila-mellar liposomes toalmost the same extent as a segment that includes the N-terminal fusion peptide....
9p
research12
23-04-2013
39
1
Download
-
Translocation through the plasma membrane is a major limiting step for the cellular delivery of macromolecules. A promising strategy to overcome this problem consists in the chemical conjugation (or fusion) to cell penetrating peptides (CPP) derived from proteins able to cross the plasma membrane. A large number of dierent cargo mol-ecules such as oligonucleotides, peptides, peptide nucleic acids, proteins or even nanoparticles have been internalized in cells by this strategy.
8p
research12
23-04-2013
27
3
Download
-
The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amyloid b-peptides (Ab),which derive from the proteolitic cleavage of theamyloidprecursorproteins.InvitroAbmayundergoa conformational transition from a soluble form to aggrega-ted,fibrillary b-sheet structures,which seem to be neuro-toxic. Alternatively,it has been suggested that ana-helical form can be involved in a process of membrane poration, which would then trigger cellular death.
7p
tumor12
22-04-2013
34
1
Download
-
In Klebsiella pneumoniae, the flavoprotein, NifL regulates NifA mediated transcriptional activation of the N2-fixation (nif) genes in response tomolecular O2and ammonium.We investigated the influence of membrane-bound oxidoreduc-tases on nif-regulation by biochemical analysis of purified NifLandbymonitoringNifA-mediated expressionofnifH¢-¢lacZ reporter fusions in different mutant backgrounds. NifL-bound FAD-cofactor was reduced by NADH only in the presence of a redox-mediator or inside-out vesicles derived from anaerobically grown K.pneumoniaecells,...
12p
tumor12
20-04-2013
30
2
Download
-
Oxysterol binding protein (OSBP) and its homologs have been shown to regulate lipid metabolism and vesicular transport. However, the exact molecular function of individual OSBP homologs remains uncharacterized. Here we demonstrate that the yeast OSBP homolog, Osh6p, bound phos-phatidic acid and phosphoinositides via its N-terminal half containing the conserved OSBP-related domain (ORD). Using a green fluorescent protein fusion chimera, Osh6p was found to localize to the cytosol and patch-like or punctate structures in the vicinity of the plasma membrane....
13p
fptmusic
12-04-2013
50
1
Download
-
The structure and membrane interaction of the internal fusion peptide (IFP) fragment of the avian sarcoma and leucosis virus (ASLV) envelope glycoprotein was studied by an array of biophysical methods. The peptide was found to induce lipidmixing of vesicles more strongly than the fusion peptide derived from the N-terminal fusion peptide of influenza virus (HA2-FP). It was observed that the helical structure was enhanced in association with the model membranes, particularly in the N-terminal portion of the peptide.
12p
awards
05-04-2013
33
2
Download
-
TRPM4b is a Ca 2+ -activated, voltage-dependent monovalent cation chan-nel that has been shown to act as a negative regulator of Ca 2+ entry and to be involved in the generation of oscillations of Ca 2+ influx in Jurkat T-lymphocytes. Transient overexpression of TRPM4b as an enhanced green fluorescence fusion protein in human embryonic kidney (HEK) cells resulted in its localization in the plasma membrane, as demonstrated by confocal fluorescence microscopy.
10p
galaxyss3
21-03-2013
34
3
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)