Membranous nephropathy

According to recent studies, the phospholipase A2 receptor 1 (PLA2R1) may be used as a biomarker to diagnose idiopathic membranous nephropathy (iMN). Moreover, the immune-dominant regions of PLA2R1 have been identified.

6p vihamax2711 21-04-2020 13 1   Download

The role of immune complexes formed in situ has been most extensively studied in the Heymann nephritis model in the rat, a human counterpart of membranous nephropathy (MN). This is a non-proliferative form of GN in which the humoral, Th2 responses play an important role. In human idiopathic MN, an increase in the percentage of IL-4 (Masutani et al. 2004) and IL-10 (Hirayama et al. 2002) was observed in peripheral blood T cells, which correlated with the amount of proteinuria.

420p kmkmkmkmkm 08-09-2012 37 4   Download

An additional factor for lack of better therapeutic choices is the lack of suitable animal models to replicate human glomerular injury in order to develop and test novel treatment strategies. There are three detailed chapters that exemplify the recent advances in using animal models to explore the pathogenesis of glomerulonephritis. Immunopathogenic mechanisms in a murine model of membranous nephropathy are discussed by Chia-Chao Wu et al., while autoimmune glomerulonephritis complicating chronic graft versus host reaction was discussed by Elena Goiman et al....

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The currently available treatment options for glomerular disorders are not optimal since most of them either respond only partially or poorly so that relapse and progression is often the rule. Inadequate understanding of the factors underlying the development and progression of glomerular injury in various clinical scenarios is primarily responsible for lack of ideal therapies. The section on immune system and glomerulonephritis has three chapters which basically cover some of the actively investigated areas. Tetsuhiro Tanaka et al.

224p kmkmkmkmkm 08-09-2012 69 5   Download

This book is produced not as a comprehensive review of current understanding of the pathogenesis of glomerulonephritis but rather as a series of well selected individual update chapters that provide snapshots of the breadth and depth of renal science, as it exists today. Thus, chapters cover the dual roles of the innate immune system in mediating disease and initiating the immune response (Yahuan Lou), while others focus on both the humoral and cellular arms of the adaptive immune system (Tetsuhiro Tanaka et al.

150p kmkmkmkmkm 08-09-2012 73 7   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Membranous nephropathy in a patient with hereditary angioedema: a case report

4p dauphong1 21-12-2011 40 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Anti-glomerular basement membrane disease superimposed on membranous nephropathy: a case report and review of the literature...

5p thulanh27 12-12-2011 68 3   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Membranous nephropathy and lupus-like syndrome after hematopoietic cell transplantation: a case report

4p toshiba25 09-12-2011 31 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan

8p toshiba23 18-11-2011 49 1   Download

Isolated microscopic hematuria can be a manifestation of glomerular diseases. The RBCs of glomerular origin are often dysmorphic when examined by phase-contrast microscopy. Irregular shapes of RBCs may also occur due to pH and osmolarity changes produced along the distal nephron. There is, however, significant observer variability in detecting dysmorphic RBCs. The most common etiologies of isolated glomerular hematuria are IgA nephropathy, hereditary nephritis, and thin basement membrane disease. IgA nephropathy and hereditary nephritis can lead to episodic gross hematuria.

5p ongxaemnumber1 29-11-2010 73 2   Download