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MET receptor
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As a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor (MET) exhibits high aberrant expression across various tumors. This study aimed to evaluated the safety, tolerability, efficacy and pharmacokinetics (PK) of BPI-9016M, a novel tyrosine kinase inhibitor (TKI) targeting c-MET, in c-MET overexpression or MET exon 14 skipping mutation patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC).
13p
vischultz
20-10-2023
3
1
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Well-differentiated (WD) neuroendocrine tumors (NETs) are a group of rare neoplasms with limited therapeutic options. Cabozantinib is an inhibitor of multiple tyrosine kinases with a pivotal role in NET pathogenesis, including c-MET and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2).
10p
vioracle
29-09-2023
8
2
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Non-small cell lung cancers (NSCLC) are highly heterogeneous at the molecular level and comprise 75% of all lung tumors. We have previously shown that the receptor tyrosine kinase (RTK) MET frequently suffers gain-of-function mutations that significantly promote lung tumorigenesis.
12p
virose2711
25-09-2020
8
0
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Deregulation of receptor tyrosine kinases (RTK) contributes to the initiation and progression of intestinal-derived epithelial cancers, including colorectal cancer (CRC). However, the roles of the proximal signaling molecules engaged by RTKs in different oncogenic functions of CRC remain unclear.
15p
virose2711
25-09-2020
10
1
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Hepatocellular carcinoma (HCC) patients with active hepatocyte growth factor (HGF)/c-Met signaling have a significantly worse prognosis. c-Met, a high affinity receptor for HGF, plays a critical role in cancer growth, invasion and metastasis. c-Met and CD44 have been utilized as cell surface markers to identify mesenchymal tumorinitiating stem-like cells (TISC) in several cancers including HCC.
11p
vialabama2711
21-09-2020
14
1
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The prognosis of synovial sarcoma (SS), an aggressive soft tissue sarcoma, remains poor. We previously reported that c-MET or platelet-derived growth factor receptor α (PDGFRα) signalling pathway is related to SS progression based upon the findings of phospho-receptor tyrosine kinase (RTK) arrays.
14p
vidhaka2711
31-07-2020
10
1
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Activation of c-Met, a receptor tyrosine kinase, induces radiation therapy resistance in non-small cell lung cancer (NSCLC). The activated residual of c-Met is located in lipid rafts (Duhon et al. Mol Carcinog 49:739-49, 2010).
11p
vibaku2711
22-07-2020
10
2
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Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis. Recurrence and metastasis rates in LPS remain high even after chemotherapy and radiotherapy following complete resection.
12p
vikuala271
13-06-2020
8
0
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HGF/MET pathway may have a role in pulmonary hypertension (PH). However, the link between the pathway and development of target organ damage in PH remains elusive. We aimed to demonstrate the relation between plasma HGF and HGF/MET tissue expressions in affected organs during PH progression.
10p
vinasaki2711
12-11-2019
13
1
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The definition of research priorities for the European food sector will necessarily focus on the single stages of the food chain, from raw material production through post harvesting, processing, post-processing, and distribution to the end consumer. Therefore it’s essential to have at the beginning an idea of the current state of the art of the sector and the main developments along the food chain at the moment. During the next 10 years, the European food sector will continue its since long ongoing structural transition.
34p
conduongdinhmenh
07-05-2013
51
4
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Residue Leu10 of substance P (SP) is critical for NK-1 receptor recognition and agonist activity. In order to probe the bioactive conformation of this residue,cis-andtrans-3-substituted prolinoleucines were introduced in position 10 of SP. The substituted SP analogues were tested for their affinity to humanNK-1 receptor specific binding sites (NK-1M and NK-1m) and their potency to stimulate adenylate cyclase and phospholipase C in CHO cells transfected with the human NK-1 receptor.
10p
fptmusic
16-04-2013
31
3
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Chronic obstructive pulmonary disease is a major clinical disorder usually associated with cigarette smoking. A central feature of chronic obstructive pulmonary disease is inflammation coexisting with an abnormal protease/anti-protease balance, leading to apoptosis and elastolysis. In anin vitro study of rat lung alveolar L2 cells, cigarette smoke extract (CSE) induced apoptotic cell death. Expo-sure of L2 cells to CSE at a concentration of 0.25% resulted in a 50% increase of caspase-3 and matrix met-alloproteinase (MMP) activities.
11p
dell39
03-04-2013
51
2
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We report the development of a high-level bacterial expression system for the Alzheimer’s disease-associated amyloid b-peptide (Ab), together with a scaleable and inexpensive purification procedure. Ab(1–40) and Ab(1–42) coding sequences together with added ATG codons were cloned directly into a Pet vector to facilitate production of Met-Ab(1–40) and Met-Ab(1– 42), referred to as Ab(L1–40) and Ab(L1–42), respectively.
11p
vinaphone15
27-02-2013
42
1
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Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor⁄scatter factor. Hepatocyte growth factor⁄scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its recep-tor, MET. In vivo, HGFA also activates macrophage-stimulating protein, which has roles in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor, RON....
8p
mobifone23
21-01-2013
32
3
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Our aim is to provide a high level of service that the principals of Esquire Management Group see is often lacking in today’s business practices. It is our aim to create partnerships of service with our clients to ensure that our clientele’s needs and goals are met. We are here to serve you, by listening and responding to your interests. We will work to ensure the highest possible net return to the property owners over the longest period of time.
5p
connhobinh
07-12-2012
39
3
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Hospitals, health care systems, and health care providers are also affected by a mass trauma. The number of people who need immediate physical and psychological help may be too much for health systems to handle. Some patients may not ind help when they need it because hospitals do not have enough staff or supplies. In some cases, health care providers themselves may be struggling to recover as well. NIMH scientists are working on this problem. For example, research ers are testing how to give CBT and other treatments using the phone and the Internet.
112p
quygia123
06-11-2012
51
1
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In the Western world, the arrival in the 20th century of the Welfare State meant that the basic needs of citizens in terms of health, hygiene and socio-economic considerations were met to a greater extent than ever before. It soon however became apparent that, as Maslow’s hierarchy of need predicts (Maslow, 1943), people continued to want more, they needed choices, and they sought opportunities to fulfil ambitions and goals.
200p
ti_du_hoang
02-08-2012
49
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài:" The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells...
10p
toshiba10
15-10-2011
33
1
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Morphin nội sinh Hai năm sau khi tìm ra receptor của opiat, một số công trình nghiên cứu cho thấy receptor của morphin còn có ái lực rất mạnh với một số peptid đặc hiệu sẵn có trong cơ thể động vật, những peptid này gây ra những tác dụng giống morphin. Các morphin nội được chia thành 3 họ: - Enkephalins (Met - enkephalin và leu - enkephalin) - Endorphins - Dynorphins Mỗi loại có tiền thân khác nhau và phân bố ở những vị trí khác nhau trên thần kinh tru ng ương. Các morphin nội sinh hoạt động như một...
5p
super_doctor
25-10-2010
119
17
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