Metabolic regulation

Ovarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it is vital to determine the prognostic value and therapy response of PCD-related genes in OC.

17p vishanshan 27-06-2024 1 1   Download

RNA interactomes and their diversified functionalities have recently benefited from critical methodological advances leading to a paradigm shift from a conventional conception on the regulatory roles of RNA in pathogenesis.

14p vishanshan 27-06-2024 2 1   Download

Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation.

12p vikoch 27-06-2024 1 1   Download

This study aims to identify functionally relevant lncRNAs impacting OS proliferation and lipid metabolism and seeks to shed light on the upstream regulatory mechanisms governing lipogenic enzyme activity. Based on comprehensive bioinformatic analysis and the establishment of a risk model, we identified seven lncRNAs signifcantly associated with clinical characteristics and lipid metabolism-related genes in patients with OS.

15p vikoch 27-06-2024 1 1   Download

Part 2 book "Anaesthesia science" includes content: Fluids and electrolytes, the microcirculation, respiratory physiology at the molecular level, non-respiratory functions of the lun, the brain as a site of inflammation after acute injury, heart failure, the hormonal and metabolic response to anaesthesia, surgery and trauma, temperature regulation.

269p zizaybay1101 30-04-2024 5 2   Download

Ebook "CtBP family proteins" are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the molecular basis of its dual activity and the interaction with target peptides.

131p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "The long and short noncoding RNAs in cancer biology" conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance).

455p tracanhphuonghoa1007 22-04-2024 4 2   Download

Part 2 book "Textbook of veterinary physiology" includes content: General endocrinology and hormones of hypothalamus and pituitary; hormonal regulation of metabolism, water and minerals; hormones of gonads and non classical endocrine organs; development of sex organs; functional morphology of the male reproductive system; spermatogenesis and semen; functional morphology of the female reproductive system; female reproductive physiology; fertilisation, gestation and parturition; assisted reproductive technologies in farm animals,... and other contents.

424p muasambanhan10 03-04-2024 3 1   Download

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system.

16p vibransone 28-03-2024 2 1   Download

Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes (T2D). However, the underlying biological mechanisms for many of these associations remain unknown. GWAS signals close to the glucokinase regulatory protein gene (GCKR) have been reported for lipid and glucose metabolism traits and the risk of T2D.

14p vioraclene 31-03-2024 2 2   Download

Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, emphasizes the interlinked nature of host metabolism and the disease.

13p vioraclene 31-03-2024 6 2   Download

The liver X receptors (LXRs, NR1H2 and NR1H3) and peroxisome proliferator-activated receptor gamma (PPARG, NR1C3) nuclear receptor transcription factors (TFs) are master regulators of energy homeostasis. Intriguingly, recent studies suggest that these metabolic regulators also impact tumor cell proliferation.

16p vioraclene 31-03-2024 5 2   Download

Epidemiological and animal studies have reported that prenatal nicotine exposure (PNE) leads to obesity and type-2 diabetes in offspring. Central leptin-melanocortin signaling via hypothalamic arcuate proopiomelanocortin (POMC) neurons is crucial for the regulation of energy and glucose balance.

27p vioraclene 31-03-2024 7 2   Download

The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can dissect the genetic contributions to metabolome and transcriptome regulations.

15p vioraclene 31-03-2024 3 2   Download

Ebook "Post-transcriptional regulation by STAR proteins: Control of RNA metabolism in development and disease" reviews the available information on the structure of the RNA binding STAR domain and provides insights into how these proteins discriminate between different RNA targets; Overviews of the post-translational modifications of STAR proteins and their effects on biological functions.

176p cotieubac1004 15-03-2024 3 0   Download

Part 1 book "Advanced nutrition and human metabolism" includes content: The cell - A microcosm of life, the digestive system - mechanism for nourishing the body, carbohydrates, fiber, lipids, protein, integration and regulation of metabolism and the impact of exercise, energy expenditure, body composition and healthy weight.

323p muasambanhan08 01-03-2024 6 2   Download

Ebook "Epigenetics in plants of agronomic importance: Fundamentals and applications (Transcriptional regulation and chromatin remodelling in plants)" provides a detailed understanding of the epigenetic mechanisms involved in plants of agronomic importance. The information presented here is significant because it is expected to provide the knowledge needed to develop in the future treatments to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases and to increase crop productivity.

158p manmanthanhla0201 26-02-2024 6 1   Download

Part 1 book "Advanced nutrition and human metabolism" includes content: The cell - A microcosm of life; the digestive system - mechanism for nourishing the body; carbohydrates; fiber; lipids; protein; integration and regulation of metabolism and the impact of exercise and sport; body composition, energy expenditure, and energy balance.

331p muasambanhan08 23-02-2024 3 1   Download

Part 2 book "Equine clinical nutrition" includes content: Feeding horses - Manufactured feeds, dietary supplements, USA feed regulations and safety, feeding and drinking behaviors, feeding adult and senior horses, feeding athletes and working horses, feeding stallions, feeding broodmares, feeding growing horses, pain and discomfort behaviors, weight management, refeeding and assisted feeding of horses, musculoskeletal system disorders, digestive system disorders, endocrine system disorders, metabolic syndrome.

308p muasambanhan08 23-02-2024 4 1   Download

Part 2 book "Ruminant physiology - Digestion, metabolism, growth and reproduction" includes content: Muscle growth and genetic regulation, control and manipulation of hyperplasia and hypertrophy in muscle tissue, regulation of protein synthesis for wool growth, regulation of macronutrient partitioning between maternal and conceptus tissues in the pregnant ruminant, the thermal physiology of the ruminant fetus,... and other contents.

262p muasambanhan07 20-02-2024 3 0   Download