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Metallo-β- lactamases
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Bài viết trình bày xác định tỷ lệ nhiễm và tỷ lệ mang gen kháng thuốc MBL, gồm 3 kiểu gen imipenemase (IMP), Verona integron-encoded MBLs (VIM), New Delhi metallo-β-lactamase (NDM) trên các trực khuẩn gram âm Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa và Klebsiella pneumoniae, phân lập từ mẫu bệnh phẩm đường hô hấp dưới ở bệnh nhân viêm phổi.
8p
viellison
06-05-2024
10
2
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Bài viết trình bày tỷ lệ gen kháng thuốc metallo-βlactamase NDM, IMP, VIM và tìm hiểu mối liên quan giữa kiểu gen trên với đề kháng kháng sinh nhóm carbapenem của trực khuẩn gram âm Escherichia coli, Klebsiella pneumoniae, Acinebacter baumannii và Pseudomonas aeruginosa trên bệnh nhân viêm phổi tại Bệnh viện Đa khoa thành phố Cần Thơ năm 2022-2023.
6p
vioraclene
16-04-2024
3
1
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Escherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodefciency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae.
4p
vilazada
31-01-2024
3
2
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Từ những năm 80 của thế kỉ XX, carbapnemase được coi là vũ khí cuối cùng để chống lại các vi khuẩn Gram âm đa kháng thuốc. Việc phát hiện các chủng vi khuẩn E. coli mang gen kháng kháng sinh mới: New Delhi metallo-β-lactamase (blaNDM-1) trên người đã được biết đến trong những năm qua; Tuy nhiên, rất ít các nghiên cứu được tiến hành trên động vật tại Việt Nam. Mục đích của nghiên cứu là khảo sát tính đề kháng và đánh giá kiểu hình, kiểu gen của các chủng E. coli kháng carbapenem trên chó khỏe mạnh ở Đắk Lắk.
11p
viericschmid
12-01-2022
36
1
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This study was taken up, to compare different phenotypic tests for identification of producing P. aeruginosa from pus samples. This possibly will help to prevent the associated morbidity and mortality caused due to this organism by implementing proper control measures and to evaluate antibiotic therapy.
8p
cothumenhmong9
04-01-2021
9
1
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The study was done in Department of Microbiology, RMC, Loni. The clinical samples were subjected to Gram staining, aerobic culture using MacConkey and blood agar. Acinetobacter species were identified by standard microbiological identification methods. Antimicrobial susceptibility testing was done by Kirby Bauer disc diffusion technique and according to CLSI guidelines.
9p
angicungduoc8
07-11-2020
11
1
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This retrospective study aims to analyze various uropathogens and their antimicrobial susceptibility pattern in a tertiary care hospital, which assist in selecting the most appropriate antibiotic therapy in treatment of Urinary Tract Infection.
8p
cothumenhmong7
09-09-2020
11
1
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Neonatal septicemia is responsible for nearly half of neonatal deaths. With emerging drug resistance mechanisms like Metallo Beta lactamase (MBL) production, treatment of neonatal sepsis has become a challenge. The present study was done to identify prevalence of bacterial pathogens, their resistance profile and incidence of MBL mediated resistance among Gram negative bacterial isolates in neonatal sepsis. Seventy three cases of suspected neonatal septicemia were included in this prospective study. Blood culture was done by BacT/Alert 3D system, bacterial isolates were identified.
7p
angicungduoc6
20-07-2020
10
1
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Pseudomonas aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infection causing serious infections in patients who are mechanically ventilated individuals, who are immunocompromised, and patients with malignancies or HIV infection. The present study was undertaken with the aim to find prevalence of Metallo-β-Lactamases producing Pseudomonas aeruginosa among clinical isolates by different phenotypic confirmatory methods.
7p
nguaconbaynhay6
24-06-2020
14
1
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Metallo-β-lactamases (MβLs) production in gram negative bacilli is an emerging health problem worldwide. We aimed to determine the occurrence of MβLs among gram negative bacilli (GNB) by phenotypic and genotypic methods in Mansoura University hospital, Egypt. We conducted a prospective study on 107 GNB isolates recovered from different clinical specimens collected from different patients. Species identification and antibiotic susceptibility profile was determined by MicroScan Wa1kAway system.
10p
nguaconbaynhay6
24-06-2020
7
0
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Infections caused by multidrug-resistant bacteria expressing
9p
quenchua6
15-06-2020
15
1
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Acinetobacter species are the commonest pathogens causing nosocomial infections. Acinetobacter is essentially resistant to many antibiotics and they are known to produce extended spectrum beta lactamase and metalo beta lactamase. Aim of the study is to detect Metalo beta lactamase producing Acinetobacter spp. from clinical samples in tertiary care hospital. Between January 2015 and June 2015, total 368 Acinetobacter spp were isolated from different clinical samples.
10p
gaocaolon5
14-06-2020
10
1
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Acinetobacter, has been identified as an important pathogen in nosocomial outbreaks with high levels of emerging drug resistance. So the present study was conducted in Acinetobacter spp to find out the utility of the multiplex PCR assay, which may be used as a useful technique in the early detection & prevention of NDM-1 gene harbouring in clinical isolates taken from the patients coming to the tertiary care hospital.
5p
angicungduoc5
12-06-2020
10
0
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Acinetobacter causes a wide variety of illness in debilitated and hospitalized patients. Carbapenem resistance in Acinetobacter is an emerging problem and is a cause of concern as many nosocomial infections with Acinetobacter are resistant to most other antibiotics. The present study was aimed to study metallo-β-lactamase (MBL) production in Acinetobacter species. During one year study (Sep.2010 to Aug.2011), all isolates of Acinetobacter obtained from various clinical samples like respiratory, pus, blood and others were included.
6p
kethamoi5
03-06-2020
36
0
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The aim of this study was to analyze the extended spectrum of β lactamase (ESBL), metallo β lactamase (MBL) and AmpC production in Pseudomonas aeruginosa in various clinical samples. A Total of 100 clinical isolates of P. aeruginosa were collected from different clinical specimen and confirmed by standard tests. Antibiotic susceptibility was determined by the Kirby-Bauer disc diffusion method. ESBL screening was done using 3rd generation cephalosporins and confirmatory combined double disc test, imipenem-EDTA double disc synergy test for MBL enzyme and AmpC test using Cefoxitin disc.
9p
trinhthamhodang1213
30-05-2020
11
1
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This situation prompts early and accurate detection of MBL producers. Hence the present study was done to phenotypically evaluate the prevalence of MBL production among 235 clinical isolates of Pseudomonas aeruginosa (183) and Acinetobacter species (52). The antimicrobial susceptibility testing was done by Kirby Bauer disk diffusion method.
11p
trinhthamhodang5
16-05-2020
13
1
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Non fermenting Gram Negative Bacilli (NFGNB) once considered as contaminants, now emerged as a major cause of life threatening nosocomial infections and as multidrug resistant pathogens. Acinetobacter species are the opportunistic pathogens with increasing prevalance in the nosocomial infections. Community acquired infections are also common in Acinetobacter. It accounts for 10% of all community-acquired bacteremic pneumonias. To isolate, identify and detect Carbapenem resistance producing Acinetobacter spp., and confirm Metallo Beta Lactamase ( MBL) production by phenotypic methods.
10p
trinhthamhodang5
16-05-2020
15
1
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The present study was done to detect Extended spectrum β lactamase and metallo-βlactamase producing isolates of Pseudomonas aeruginosa from various clinical samples from patients admitted in Tirunelveli Government medical college hospital. In this study we studied the prevalence of ESBL and MBL among 112 Pseudomonas aeruginosa isolates, following standard methods of isolation and identification of these bacteria from clinical materials
8p
kethamoi4
18-04-2020
15
0
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Resistance to carbapenems is an emerging problem among Klebsiella pneumoniae isolates. A simple and effective phenotypic detection method for carbapenemase production is required in health care settings. A total of 100 clinical isolates of Klebsiella pneumoniae from various samples were screened for imipenem resistance. The imipenem resistant strains were further tested for metallo-beta-lactamase (MBL) production by imipenem combined disc test and ceftazidime combined disc test.
6p
kethamoi4
16-04-2020
8
1
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Acinetobacter calcoaceticus baumannii (ACB) is a significant pathogen in hospitals with a growing incidence of multi-drug resistant (MDR) strains. This was a prospective study carried out on ACB isolates from clinical samples between 2013 and 2015. Anti-microbial susceptibility testing was done by Kirby-Bauer Disk Diffusion method (KBBD) method. CRAB strains were tested by Modified Hodge test (MHT) to detect MBL producers. Of the 190 ACB isolates, 142 (75%) were MDR strains. 93% were hospital acquired and 7% community acquired. MDR was seen only in hospital acquired isolates.
11p
cothumenhmong4
25-03-2020
16
1
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