Methylation data
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Garcinia multiflora belonging to the Clusiaceae family is one of the medicinal plant species native to Viet Nam and southern China and its use is an ethno-medicinal remedy to treat acne, scabies, constipation, and inflammation. In this paper, the chemical investigation on the fruits of Garcinia multiflora growing in the north of Vietnam was reported.
9p viamancio 04-06-2024 1 0 Download
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From CHCl3-soluble extract of the leaves of Taxus wallichiana (Taxaceae), collected in Lam Dong Province, five compounds were isolated and identified as sciadopitysin, ginkgetin, (S)-(+)-rhododenol, (+)-erythro-N-benzoyl3-phenylisoserine methyl ester, and (−)-α-conidendrin (5). Their chemical structures were determined by 1D and 2D NMR spectra and comparison with published data. Except for (−)-α-conidendrin, these remaining compounds were first reported of Taxus wallichiana.
6p dianmotminh02 03-05-2024 5 3 Download
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wo germacranolide sesquiterpenes, 9β-acetoxy-3-epi-nobilium, zoapatanolide B and four benzoate ester derivatives, benzyl 2-O-β-D-glucopyranosyl-6-methoxybenzoate, benzyl 2-O-β-D-glucopyranosyl-6- hydroxybenzoate, methyl 2-O-β-D-glucopyranosylbenzoate, ficuside G were isolated from aerial part of Sigesbeckia orientalis. Structural elucidation of the isolated compounds was done using a combination of HR-ESI-MS, one-dimensional and two-dimensional NMR spectral methods, and comparison their spectral data with the previous literature.
7p dianmotminh02 03-05-2024 4 2 Download
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Advances in cancer biology are increasingly dependent on integration of heterogeneous datasets. Large-scale efforts have systematically mapped many aspects of cancer cell biology; however, it remains challenging for individual scientists to effectively integrate and understand this data.
12p vibransone 28-03-2024 5 2 Download
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In this study, we dissect the subcutaneous adipose tissue (SAT) methylome signature relevant to metabolic health by focusing on VF as the major risk factor of metabolic disease. We integrate results with genetic, blood methylation, SAT gene expression, blood metabo‑ lomic, dietary intake and metabolic phenotype data to assess and quantify genetic and environmental drivers of the identified signals, as well as their potential functional roles.
22p viellison 28-03-2024 4 2 Download
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Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.
4p viellison 28-03-2024 6 2 Download
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Variation in cell composition can dramatically impact analyses in bulk tissue samples. A commonly employed approach to mitigate this issue is to adjust statistical models using estimates of cell abundance derived directly from omics data.
14p vicwell 29-02-2024 3 1 Download
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Ebook "Cancer systems biology: Methods and protocols" comprises protocols describing systems biology methodologies and computational tools, offering a variety of ways to analyze different types of high-throughput cancer data. Chapters give an overview over data types available in large-scale data repositories and state-of-the-art methods used in the field of cancer systems biology.
397p lucchinguyen 28-12-2023 7 2 Download
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Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects of different biological data types can boost learning capabilities and lead to a better understanding of the underlying interactions among molecular levels.
10p visteverogers 24-06-2023 8 2 Download
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From the ethyl acetate extract of the leaves of Amensiodendron chinense (Merr.) Hu (Sapindaceae), we isolated three known phenolic compounds: 4-hydroxy-3-methoxybenzaldehyde (1), methyl 3,4-dihydroxybenzoate (2), and 3,4-dihydroxybenzoic acid (3). We elucidated their chemical structures from the spectral data and compared them with those reported in the literature.
5p vispiderman 15-06-2023 6 2 Download
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Study of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on brain tissue between human and rhesus on two methylation cytosine variants based data-profiles (viz., 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) samples) through TF-miRNA-gene network based module detection.
22p vinarcissa 21-03-2023 1 1 Download
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We propose a novel Markov Blanket-based repeated-fishing strategy (MBRFS) in attempt to increase the power of existing Markov Blanket method (DASSO-MB) and maintain its advantages in omic data analysis.
14p vinarcissa 21-03-2023 4 1 Download
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DNA methylation plays a key role in development, contributes to genome stability, and may also respond to external factors supporting adaptation and evolution. To connect different types of stimuli with particular biological processes, identifying genome regions with altered 5-methylcytosine distribution at a genome-wide scale is important.
9p vinarcissa 21-03-2023 4 1 Download
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The research project deals with two different types of data for two separate analysis. The first analysis deals with normalised RNA-seq breast cancer data where machine learning techniques are used to classify and identify the biomarker of cancer. Second analysis deals with raw DNA methylated leukemia samples to determine the mutations.
102p runthenight04 02-02-2023 4 2 Download
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An important feature in many genomic studies is quality control and normalization. This is particularly important when analyzing epigenetic data, where the process of obtaining measurements can be bias prone.
6p vihagrid 30-01-2023 9 3 Download
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Association studies using a single type of omics data have been successful in identifying diseaseassociated genetic markers, but the underlying mechanisms are unaddressed. To provide a possible explanation of how these genetic factors affect the disease phenotype, integration of multiple omics data is needed.
5p vihagrid 30-01-2023 5 3 Download
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Genome-wide association studies performed on triglycerides (TGs) have not accounted for epigenetic mechanisms that may partially explain trait heritability. Parent-of-origin (POO) effect association analyses using an agnostic approach or a candidate approach were performed for pretreatment TG levels, posttreatment TG levels, and pre-and posttreatment TG-level differences in the real GAW20 family data set.
5p vihagrid 30-01-2023 6 3 Download
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An accumulation of evidence has revealed the important role of epigenetic factors in explaining the etiopathogenesis of human diseases. Several empirical studies have successfully incorporated methylation data into models for disease prediction. However, it is still a challenge to integrate different types of omics data into prediction models, and the contribution of methylation information to prediction remains to be fully clarified.
5p vihagrid 30-01-2023 6 3 Download
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Multiple layers of genetic and epigenetic variability are being simultaneously explored in an increasing number of health studies. We summarize here different approaches applied in the Data Mining and Machine Learning group at the GAW20 to integrate genome-wide genotype and methylation array data.
8p vihagrid 30-01-2023 3 3 Download
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The rise in popularity and accessibility of DNA methylation data to evaluate epigenetic associations with disease has led to numerous methodological questions. As part of GAW20, our working group of 8 research groups focused on gene searching methods.
9p vihagrid 30-01-2023 11 3 Download