Microrna regulation in disease

important regulators of biological processes in animals and plants. MiRNAs regulate gene expression at the posttranscriptional level by binding to mRNAs and either inhibit translation or modify the stability of the mRNA. Due to the important biological role of miRNAs it is of great interest to study their expression level in the cells. Furthermore, miRNAs have been associated with cancer and other diseases [1] and miRNA expression can help in the diagnosis and prognostic of human disease [2,3].

11p zingzing09 24-04-2013 51 3   Download

Many recent studies have reported that microRNA (miRNA) biogenesis and function are related to the molecular mechanisms of various clinical diseases. Several methods, including northern blotting and DNA chip anal-yses, are capable of assessing miRNA-production patterns in cells. How-ever, the development of repetitive monitoring of the miRNA-production profile in a noninvasive manner is demanded for the application of miRNAs to human medicine.

10p viettel02 22-02-2013 42 2   Download

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovas-cular system under some pathological conditions.

15p cosis54 05-01-2013 44 5   Download

MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate gene expression by cleaving mRNAs or inhibiting translation. The baboon is a well-characterized cardiovascular disease model; however, no baboon miRNAs have been identified. Evidence indicates that the baboon and human genomes are highly conserved; based on this conservation, we hypothesized that comparative genomic methods could be used to identify baboon miRNAs.

8p toshiba23 18-11-2011 56 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" MicroRNAs in inflammatory lung disease - master regulators or target practice?...

13p toshiba11 19-10-2011 41 4   Download