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Mitochondrial biogenesis
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Ebook "Mitochondrial oxidative phosphorylation: Nuclear-encoded genes, enzyme regulation, and pathophysiology" focuses on new developments in mitochondrial morphology, biogenesis, and evolution, as well as in structure and regulatory functions of the enzyme complexes of OxPhos by experts in their fi elds. Particular emphasis is given to the oxygen consuming enzyme of the respiratory chain, cytochrome c oxidase, representing a controlling step of OxPhos.
378p
tracanhphuonghoa1007
22-04-2024
3
2
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Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ coactivator-1α (PGC-1α), as a master coregulator of gene expression in mitochondrial biogenesis, was found to be transiently upregulated in microglia after AIS. However, the role of microglial PGC-1α in poststroke immune modulation remains unknown.
19p
vibransone
28-03-2024
4
2
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Ebook "Artemisinin and nitric oxide: Mechanisms and implications in disease and health" discusses both the beneficial and harmful aspects of NO in biology and medicine, and also introduces the emerging discovery of artemisinin in antitumor, antibacterial infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) was voted “Molecule of the Year” by Science magazine, and the discovery of its physiological roles has led to Nobel Prize-winning work in neuroscience, physiology and immunology.
137p
nhanphanguyet
28-01-2024
4
2
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Both mitophagy, a selective mechanism for clearance of mitochondria, and mitochondrial biogenesis are key processes determining mitochondrial content and oxidative capacity of the musculature. Abnormalities in these processes could therefore contribute to deterioration of peripheral muscle oxidative capacity as observed in e.g. chronic obstructive pulmonary disease.
21p
vimaine2711
26-03-2021
11
2
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Helicases play crucial role in almost all the nucleic acid metabolism including replication, repair, recombination, transcription, translation, ribosome biogenesis and splicing and these processes regulate plant growth and development.
9p
viminato2711
22-05-2020
12
2
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Uncoupling protein one (UCP1) is a mitochondrial inner membrane protein capable of uncoupling the electrochemical gradient from adenosine-5′-triphosphate (ATP) synthesis, dissipating energy as heat. UCP1 plays a central role in nonshivering thermogenesis in the brown adipose tissue (BAT) of hibernating animals and small rodents.
15p
viminato2711
22-05-2020
10
0
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Mitochondrial uncoupling protein 1 (UCP1) is a speci®c marker of multilocular brown adipocytes. Ectopic UCP1 in white fat of aP2-Ucp1micemitigates development of obesity byboth, increasing energy expenditure anddecreasingin situ lipogenesis. In order to further analyse consequences of respiratory uncoupling inwhite fat, the eects of the ectopic UCP1 on the morphology of adipocytes and biogenesis of mitochondria in these cells were studied.
10p
research12
29-04-2013
37
2
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Alterations in mitochondrial activity resulting from defects in mitochond-rial DNA (mtDNA) can modulate the biogenesis of mitochondria by mech-anisms that are still poorly understood. In order to study mitochondrial biogenesis in cells with impaired mitochondrial activity, we used rho-L929 and rho 0 143 B cells (partially and totally depleted of mtDNA, respectively),
25p
fptmusic
12-04-2013
53
2
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Mitochondrial biogenesis is a complex and highly regulated process that requires the controlled expression of hundreds of genes encoded in two separated genomes, namely the nuclear and mitochondrial genomes. To identify regulatory proteins involved in the transcriptional control of key nuc-lear-encoded mitochondrial genes, we have performed a detailed analysis of the promoter region of theasubunit of the Drosophila melanogasterF1F0 ATP synthase complex.
11p
awards
05-04-2013
37
3
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Prohibitin (PHB-1) is a highly conserved protein involved in mitochondrial biogenesis and function. It is secreted in lipid droplets from adipocytes and is present in the circulation. In adipose tissue it functions as a membrane receptor and can target binding partners to the mitochondria.
9p
dell39
27-03-2013
38
3
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Lithium is a therapeutic agent commonly used to treat bipolar disorder and its beneficial effects are thought to be due to a combination of activa-tion of the Wnt⁄b-catenin pathway via inhibition of glycogen synthase kin-ase-3b and depletion of the inositol pool via inhibition of the inositol monophosphatase-1.
17p
galaxyss3
19-03-2013
23
2
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Mitochondrial cytochromescandc1 are present in all eukaryotes that use oxygen as the terminal electron acceptor in the respiratory chain. Matura-tion of c-type cytochromes requires covalent attachment of the heme cofac-tor to the protein, and there are at least five distinct biogenesis systems that catalyze this post-translational modification in different organisms and organelles.
18p
media19
06-03-2013
36
2
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Peroxiredoxin V (PRDX5) is a member of the family of mammalian pro-teins that neutralize reactive oxygen species. The PRDX5gene is constitu-tively expressed at a high level in many human tissues, but functional elements of its promoter responsible for a high basal activity in the absence of oxidative stress have still not been identified.
11p
media19
05-03-2013
41
1
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Complex IV is the terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. The early stages of complex IV assembly involving mitochondrial DNA-encoded subunits CO1 and CO2 have been well studied.
13p
viettel02
20-02-2013
29
2
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Mitochondrial biogenesis, which depends on nuclear as well as mitochon-drial genes, occurs in response to increased cellular ATP demand. The nuclear transcriptional factors, estrogen-related receptor a (ERRa) and nuclear respiratory factors 1 and 2, are associated with the coordination of the transcriptional machinery governing mitochondrial biogenesis
13p
mobifone23
18-01-2013
32
2
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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?
13p
sting03
06-02-2012
50
2
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Deficient mitochondrial biogenesis in critical illness: cause, effect, or epiphenomenon?
2p
coxanh_4
26-10-2011
50
2
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