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Mitochondrial physiology
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Ebook "Folding for the synapse" addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex.
315p
tracanhphuonghoa1007
22-04-2024
3
2
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Ebook "Physiological mechanisms and adaptation strategies in plants under changing environment: Volume 1" discuss drought and temperature stresses and their mitigation through different means. This volume illuminates how plants that are bombarded by diverse and changing environmental stimuli, undergo appropriate physiological alterations that enable their survival. The information covered in the book is also useful in building apposite strategies to counter abiotic and biotic stresses in plants.
386p
manmanthanhla0201
26-02-2024
5
1
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Ebook "Artemisinin and nitric oxide: Mechanisms and implications in disease and health" discusses both the beneficial and harmful aspects of NO in biology and medicine, and also introduces the emerging discovery of artemisinin in antitumor, antibacterial infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) was voted “Molecule of the Year” by Science magazine, and the discovery of its physiological roles has led to Nobel Prize-winning work in neuroscience, physiology and immunology.
137p
nhanphanguyet
28-01-2024
4
2
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Part 1 book "Sturkie's avian physiology" includes content: The importance of avian physiology; avian genomics; transcriptomic analysis of physiological systems; avian proteomics; avian metabolomics; mitochondrial physiology—sturkie's book chapter; evolution of birds; domestication of poultry; the avian somatosensory system - a comparative view; avian vision; avian hearing; chemesthesis and olfaction; taste in birds; avian nociception and pain,... and other contents.
791p
muasambanhan03
02-01-2024
9
2
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Quercetin, a multifunctional therapeutic agent, is used in various types of cancer. However, its therapeutic effect is limited by virtue of poorly aqueous solubility and instability in the physiological medium. To overcome these limitations, we aimed (i) to design quercetin loaded liposomes with unlinked-PEG4000 with regard to not only surface modification but also solubility enhancement, and (ii) to investigate the antineoplastic effects on HeLa cells.
13p
lyhuyenthu
31-01-2023
2
2
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Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs in monocytes and macrophages in response to hypoxia and interferons, the physiological significance of such editing is unclear.
17p
vigalileogalilei
27-02-2022
10
1
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Adipose tissue is a major endocrine organ and is thought to play a central role in the metabolic control of reproductive function in cattle. Plane of nutrition during early life has been shown to influence the timing of puberty in both male and female cattle, though the exact biological mechanisms involved are currently unknown. The aim of this study was to investigate the effect of early calf-hood nutrition on the transcriptomic profile of subcutaneous adipose tissue in Holstein-Friesian bulls to identify possible downstream effects on reproductive physiology.
12p
vibeauty
23-10-2021
12
1
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Cumulative evidence indicates that statins induce myotoxicity. However, the lack of understanding of how statins affect skeletal muscles at the structural, functional, and physiological levels hampers proper healthcare management. The purpose of the present study was to investigate the early after-effects of lovastatin on the slowtwitch soleus (Sol) and fast-twitch extensor digitorum longus (EDL) muscles.
7p
vitennessee2711
02-02-2021
17
2
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Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is yet not well explored, as most of known cases have not been assessed by objective testing, but only by interview.
6p
vitennessee2711
02-02-2021
12
2
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All known mechanisms of apoptosis induced by resveratrol act through cell cycle arrest and changes in mitochondrial membrane potential. It is currently unknown whether resveratrol-induced apoptosis is associated with other physiological processes, such as autophagy.
10p
vibaku2711
22-07-2020
9
2
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Lactic acidosis is a common finding in neonates, in whom mitochondrial dysfunction is often secondary to tissue hypoperfusion, respiratory failure, and/or sepsis. Primary (non-physiological) lactic acidosis is comparatively rare, and suggests the presence of an inborn error of mitochondrial energy metabolism.
4p
viorochimaru2711
29-05-2020
12
0
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It is now almost 60 years since the discovery of melatonin and new physiological functions of the indole continuously appear in the most recent studies worldwide.
10p
sony2711
28-01-2019
21
1
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Mitochondrial DNA (mtDNA) deletion mutations accumulate with age in tissues of a variety of species. Although the relatively low calculated abundance of these deletion mutations in whole tissue homogenates led some investigators to suggest that these mutations do not have any physiological impact, their focal and segmental accumulation suggests that they can, and do, accumulate to levels sufficient to affect the metabolism of a tissue.
6p
research12
01-06-2013
22
3
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The effects of physiologically relevant hypoxia on the catalytic activity of cytochromecoxidase (CytOX), mito-chondrial gene expression, and both nuclear and mito-chondrial encoded CytOX mRNA levels were investigated in murine monocyte macrophages, mouse C2C12 skeletal myocytes and rat adrenal pheochromocytoma PC12 cells. Our results suggest a coordinated down regulation of mito-chondrial genome-coded CytOX I and II and nuclear genome-codedCytOX IV andVbmRNAs during hypoxia.
9p
tumor12
20-04-2013
33
2
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The humanSUV3gene encodes an NTP-dependent DNA⁄RNA DExH box helicase predominantly localized in mitochondria. Its orthologue in yeast is a component of the mitochondrial degradosome complex involved in the mtRNA decay pathway. In contrast to this, the physiological func-tion of human SUV3remains to be elucidated. In this report we demon-strate that the hSuv3 protein interacts with HBXIP, previously identified as a cofactor of survivin in suppression of apoptosis and as a protein that binds the HBx protein encoded by the hepatitis B virus....
12p
fptmusic
12-04-2013
36
1
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To assess the expression and physiological role of the mitochondrial NAD + -independent lactate dehydrogenase (iLDH) inEuglena gracilis, cells were grown with different carbon sources, and theD-andL-iLDHactivities and several key metabolic intermediates were examined. iLDH activity was significant throughout the growth period, increasing by three- to fourfold from latency to the stationary phase. Intracellular levels ofD-andL-lactate were high (5–40 mM) fromthe start of the culture and increased (20–80 mM)when the stationaryphasewas entered....
10p
fptmusic
12-04-2013
32
1
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The development of targeted probes (based on the molecular engineering of luminescent or fluorescent proteins) has allowed the specific measure-ment of [Ca 2+ ] in intracellular organelles or cytoplasmic subdomains. This approach gave novel information on different aspects of cellular Ca 2+ homeostasis. Regarding mitochondria, it was possible to demonstrate that, upon physiological stimulation of cells, Ca 2+ is rapidly accumulated in the matrix.
10p
fptmusic
11-04-2013
40
1
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Reactive oxygen species are generated by various biological systems, including NADPH oxidases, xanthine oxidoreductase, and mitochondrial respiratory enzymes, and contribute to many physiological and pathologi-cal phenomena.
12p
galaxyss3
07-03-2013
41
5
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Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thio-sulfate in three consecutive reactions has been identified in rat liver as well as in the body-wall tissue of the lugworm,Arenicola marina.
10p
galaxyss3
07-03-2013
30
2
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The principal physiological role of mitochondrial cytochromecis electron transfer during oxidative phosphorylation. c-Type cytochromes are almost always characterized by covalent attachment of heme to protein through two thioether bonds between the heme vinyl groups and the thiols of cyste-ine residues in a Cys-Xxx-Xxx-Cys-His motif.
11p
viettel02
22-02-2013
28
2
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