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Mitotic catastrophe
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To determine whether ceramide is responsible for the induction of p53-independent early or late apoptosis in response to high- and low-Linear-Energy-Transfer (LET) irradiation. Methods: Four cell lines displaying different radiosensitivities and p53-protein status were irradiated with photons or 33.4 or 184 keV/μm carbon ions.
11p
vijisoo2711
29-09-2020
11
1
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Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy. TMZ is an alkylating agent that induces autophagy, apoptosis and senescence in GBM cells.
13p
vijisoo2711
29-09-2020
9
0
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Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the antitumor mechanism of MASTL targeting in cancer cells is still unclear.
13p
vibaku2711
22-07-2020
11
3
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The goals of chemotherapy (and radiotherapy) are to eliminate tumor cell targets by promoting cell death. In recent years, a major focus has been placed on programmed cell death or apoptosis as the primary mechanism of cell killing. However, tumor cells may respond to various forms of treatment in diverse ways, only some of which culminate in cell death and loss of clonogenic survival. In addition to apoptosis, cell death may occur through mitotic catastrophe, autophagy (a subtype of apoptosis), or anoikis.
596p
spy107
11-10-2012
77
14
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Delayed cell death associated with mitotic catastrophe in g-irradiated stem-like glioma cells...
15p
toshiba10
14-10-2011
53
4
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