Molecular characterization
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Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvironment and the influx of tumor-infiltrating lymphocytes, and the combination of its inducers and immune checkpoint inhibitors plays a synergistic role in enhancing antitumor effects.
16p vishanshan 27-06-2024 1 1 Download
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The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive molecular mechanism to be elucidated. The continuous focus on both clinical and basic biology of bladder cancer leads us to characterize aberrant abundance of BACH1-IT2 associating with stabilization of Siglec-15, which eventually contributes to local immune suppressive microenvironment and therefore tumor advance.
11p vikoch 27-06-2024 1 1 Download
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In this research, a prototypical polymer system reinforced by a Silica nanoscopic inclusion is considered. Molecular Dynamics (MD) simulations are performed and used to characterize the conformational properties of the polymer chains in the neighborhood of the inclusion. It is shown that these chains are characterized by a specific tangential orientation which, together with the density profile and variations in chain mobility, allows for the geometric definition of the interphase region.
10p dathienlang1012 03-05-2024 2 0 Download
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A magnetic molecularly imprinted electrochemical sensor was developed for selective determination of sufentanil (SUF) based on carbon paste electrode (CPE) modified with methacrylic acid-ethylene glycol dimethacrylate-coated Fe3O4 nanoparticles (Fe3O4@MAA-EGDMA NPs). The structural properties, chemical structure, and electrochemical behaviors of the imprinted sensor were characterized by X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FT-IR), and square wave voltammetry (SWV), respectively.
14p dianmotminh02 03-05-2024 4 1 Download
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In this research paper we report the detailed synthesis, spectral (1H-NMR, FT-IR, and UV-Vis), crystal structure determination, DFT studies, and molecular modeling of 4-amino-3-mercapto-5-methyl-1,2,4-triazole (L2) Schiff base ligand and its complexes of cadmium as suitable bioactive agents for the treatment of malaria. From the spectroscopic results, the synthesized Schiff base has potentialtridentate coordination with themetal ion via hydroxy naphthalinic-O, azomethine-N and sulphur atom of the thione group.
17p dianmotminh02 03-05-2024 2 1 Download
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In this study, two derivatives of hydrazineylidene-3-oxopropanal: chlorophenyl (CPHO) and Nitrophenyl (NPHO) substituted hydrazineylidene compounds were synthesized, spectroscopically characterized using (FT-IR, UV, and NMR), and theoretically modelled as a potential drug for the treatment of antiviral hepatitis (HBV and HCV) using insillico molecular docking approach.
17p dianmotminh02 03-05-2024 3 1 Download
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In conclusion, sequence analysis may be useful for the rapid detection of STR resistance in MDR M. tuberculosis strains, which in turn could contribute to better control strategies of TB in Vietnam. Other molecular mechanisms associated with STR resistance in STR-resistant strains without mutations in the rpsL and rrs genes need to be further investigated.
11p dianmotminh02 03-05-2024 3 1 Download
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In this continuity, the potentiality of D. citrea essential oil was subjected to screening research. The extract yield was obtained experimentally and its chemical characterization was acquired by gas chromatography-mass spectrometry (GC-MS). The determined data was subjected as the input for computational implementations, including density functional theory calculation, molecular docking simulation, and biopharma-potential predicting analyses.
20p dianmotminh02 03-05-2024 1 1 Download
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In this study, we present an innovation method to synthesize ZnO nanoparticles colloidal solution by Zn2+ precipitation, and using COS and COS-I2 as a stabilizer agent to replace high molecular weight chitosan in previous studies. [17,18,24] It was favorable due to COS with small Mw did not precipitate at alkaline pH. Thus, ZnO/COS and ZnO/COS-I2 composite nanomaterials were prepared in this work will be oriented to use as antimicrobial agrochemicals, and post-harvest preservation.
8p dianmotminh02 03-05-2024 2 2 Download
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Ebook "Functional coherence of molecular networks in bioinformatics" will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective.
235p ladongphongthanh1008 22-04-2024 5 3 Download
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Ebook "Molecular markers in mycology: Diagnostics and marker developments" contains a thorough discussion of molecular characterization and detection of different groups of fungi by using PCR-based markers and provides a comprehensive view of the applications and uses of different molecular markers in molecular mycology. It also addresses the recent molecular markers employed to solve the problems of identification and discusses current approaches used in molecular characterization and detection of fungi.
368p tracanhphuonghoa1007 22-04-2024 1 1 Download
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Ebook "Cell death signaling in cancer biology and treatment" is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described.
412p tracanhphuonghoa1007 22-04-2024 2 1 Download
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Ebook "Theory of sum frequency generation spectroscopy" describes fundamental theory and recent advances of sum frequency generation (SFG) spectroscopy. SFG spectroscopy is widely used as a powerful tool of surface characterization, although theoretical interpretation of the obtained spectra has been a major bottleneck for most users.
273p tracanhphuonghoa1007 22-04-2024 9 3 Download
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Ebook "Zeolites in sustainable chemistry: Synthesis, characterization and catalytic applications" is devoted to the new development of zeolitic catalysts with an emphasis on new strategies for the preparation of zeolites, novel techniques for their characterization and emerging applications of zeolites as catalysts for sustainable chemistry, especially in the fields of energy, biomass conversion and environmental protection.
490p tracanhphuonghoa1007 22-04-2024 5 2 Download
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Ebook "An integrated approach for added-value products from lignocellulosic biorefineries: Vanillin, syringaldehyde, polyphenols and polyurethane" offers the state of the art on the progress and accomplishments of 25 years of research at the Associate Laboratory LSRE-LCM - Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials on lignin conversion to value-added products and their downstream separation.
173p tracanhphuonghoa1007 22-04-2024 5 2 Download
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Part 1 book "Molecular diagnostics - Fundamentals, methods, and clinical applications" includes content: Nucleic acids and proteins; gene expression and epigenetics; nucleic acid extraction methods; resolution and detection of nucleic acids; analysis and characterization of nucleic acids and proteins; nucleic acid amplifi cation; chromosomal structure and chromosomal mutations, gene mutations; DNA sequencing.
280p muasambanhan10 06-04-2024 2 0 Download
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In Vietnam, SMEDI syndrome in sows caused by PPV is nationwide and has been of concern since the early 1990s. Previous studies have investigated the prevalence of PPVs using serological testing and PCR methods. The objective of this study is to analyze the genotypic prevalence of PPVs and molecular characterization of VP gene of PPV2 from slaughtered pigs in Central Vietnam.
10p viritesh 02-04-2024 1 1 Download
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Glycosylphosphatidylinositol biosynthesis defects (GPIBDs) cause a group of phenotypically overlapping recessive syndromes with intellectual disability, for which pathogenic mutations have been described in 16 genes of the corresponding molecular pathway.
13p vibransone 28-03-2024 4 2 Download
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Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease.
18p vibransone 28-03-2024 8 2 Download
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Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium.
20p vibransone 28-03-2024 2 1 Download