Molecular identification
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In recent years, there has been an increase in the incidence and mortality rates of prostate cancer (PCa). However, the specific molecular mechanisms underlying its occurrence and development remain unclear, necessitating the identification of new therapeutic targets.
10p vishanshan 27-06-2024 2 1 Download
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Part 1 of ebook "Timber: Structure, properties, conversion and use" provides readers with contents including: nomenclature of timbers; structure of wood; gross structure; cellular structure; molecular structure; variability in structure; identification of timbers; properties of wood - influence of structure; density of wood; moisture in wood; strength, elasticity and toughness of wood;...
137p mothoiphong 28-06-2024 1 1 Download
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Considering the age relevance of prostate cancer (PCa) and the involvement of the cGAS-STING pathway in aging and cancer, we aim to classify PCa into distinct molecular subtypes and identify key genes from the novel perspective of the cGAS-STING pathway. It is of significance to guide personalized intervention of cancer-targeting therapy based on genetic evidence.
11p vikoch 27-06-2024 2 1 Download
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The sialic acid binding Ig like lectin 15 (Siglec-15) was previously identified as tumor immune suppressor gene in some human cancers with elusive molecular mechanism to be elucidated. The continuous focus on both clinical and basic biology of bladder cancer leads us to characterize aberrant abundance of BACH1-IT2 associating with stabilization of Siglec-15, which eventually contributes to local immune suppressive microenvironment and therefore tumor advance.
11p vikoch 27-06-2024 1 1 Download
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In this research, a prototypical polymer system reinforced by a Silica nanoscopic inclusion is considered. Molecular Dynamics (MD) simulations are performed and used to characterize the conformational properties of the polymer chains in the neighborhood of the inclusion. It is shown that these chains are characterized by a specific tangential orientation which, together with the density profile and variations in chain mobility, allows for the geometric definition of the interphase region.
10p dathienlang1012 03-05-2024 2 0 Download
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In this study, numerous Grateloupia spp. collected from coastal Vietnam and voucher specimens were used for morphological observation and phylogenetic analyses. Both analyses for samples collected at Nha Trang reveal a new record of G. yangjiangensis. The phylogenetic trees indicated that the herbarium vouchers labeled ‘G filicina’ and ‘G. livida’ from other locations of Vietnam group to G. yinggehaiensis clade. In addition, the phylogenetic trees also showed that the unknown Grateloupia sp. recently collected from Cat Ba Island is Phyllymenia taiwanensis. Therefore, a new record, G.
12p dianmotminh02 03-05-2024 6 1 Download
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In this continuity, the potentiality of D. citrea essential oil was subjected to screening research. The extract yield was obtained experimentally and its chemical characterization was acquired by gas chromatography-mass spectrometry (GC-MS). The determined data was subjected as the input for computational implementations, including density functional theory calculation, molecular docking simulation, and biopharma-potential predicting analyses.
20p dianmotminh02 03-05-2024 1 1 Download
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Ebook "Molecular markers in mycology: Diagnostics and marker developments" contains a thorough discussion of molecular characterization and detection of different groups of fungi by using PCR-based markers and provides a comprehensive view of the applications and uses of different molecular markers in molecular mycology. It also addresses the recent molecular markers employed to solve the problems of identification and discusses current approaches used in molecular characterization and detection of fungi.
368p tracanhphuonghoa1007 22-04-2024 1 1 Download
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Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...
203p tracanhphuonghoa1007 22-04-2024 3 2 Download
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Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.
327p tracanhphuonghoa1007 22-04-2024 3 3 Download
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Part 1 book "Textbook of microbiology and immunology" includes content: History of microbiology; morphology and physiology of bacteria; sterilization and disinfection; culture media; culture methods; laboratory identification of bacteria and taxonomy; bacterial genetics; genetic engineering and molecular methods; antimicrobial agents - therapy and resistance,... and other contents.
320p muasambanhan10 11-04-2024 7 1 Download
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Exome sequencing (ES) has been successfully applied in clinical detection of single nucleotide variants (SNVs) and small indels. However, identification of copy number variants (CNVs) using ES data remains challenging. The purpose of this study is to understand the contribution of CNVs and copy neutral runs of homozygosity (ROH) in molecular diagnosis of patients referred for ES.
17p vibransone 28-03-2024 3 1 Download
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Exome sequencing is now mainstream in clinical practice. However, identification of pathogenic Mendelian variants remains time-consuming, in part, because the limited accuracy of current computational prediction methods requires manual classification by experts.
11p vibransone 28-03-2024 3 2 Download
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Comprehensive molecular profiling has revealed somatic variations in cancer at genomic, epigenomic, transcriptomic, and proteomic levels. The accumulating data has shown clearly that molecular phenotypes of cancer are complex and influenced by a multitude of factors.
13p vibransone 28-03-2024 6 1 Download
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Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from massspectrometry (MS) datasets, as traditional proteomic analyses only identify proteins from a reference sequence database.
12p vioraclene 31-03-2024 6 2 Download
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Genome rearrangements are critical oncogenic driver events in many malignancies. However, the identification and resolution of the structure of cancer genomic rearrangements remain challenging even with whole genome sequencing.
17p vioraclene 31-03-2024 4 1 Download
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Precision medicine approaches are ideally suited for rare tumors where comprehensive characterization may have diagnostic, prognostic, and therapeutic value. We describe the clinical case and molecular characterization of an adolescent with metastatic poorly differentiated carcinoma (PDC).
17p vioraclene 31-03-2024 8 1 Download
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Phenotypic changes during cancer progression are associated with alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival.
14p vioraclene 31-03-2024 4 2 Download
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Molecular autopsy refers to DNA-based identification of the cause of death. Despite recent attempts to broaden its scope, the term remains typically reserved to sudden unexplained death in young adults. In this study, we aim to showcase the utility of molecular autopsy in defining lethal variants in humans.
11p vibransone 28-03-2024 3 2 Download
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Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...
248p tudohanhtau1006 29-03-2024 1 1 Download