Molecular tools

Circulating cell-free DNA (cfDNA, liquid biopsy) is a powerful tool to detect molecular alterations. However, depending on tumor characteristics, biology and anatomic localization, cfDNA detection and analysis may be challenging. Gliomas are enclosed into an anatomic sanctuary, which obstacles the release of cfDNA into the peripheral blood.

10p vishanshan 27-06-2024 1 1   Download

The primary aim of Cerebral Signal Transduction: From First to Fourth Messengers, therefore, is to offer a comprehensive picture of the recent advances made in the signaling field as it relates to neuronal and cere­ bral function. The current state of progress provides an exciting opportunity for such a comprehensive focus because molecular tools have become available to selectively remove, reduce, or enhance spe­ cific components in the signaling pathways, e. g. , by interfering with the genes encoding key proteins.

441p vimeyers 29-05-2024 3 2   Download

Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor.

1368p vimeyers 29-05-2024 5 2   Download

The wave function regards like localized orbital locator, electron localized function, average localized ionization energy and non-covalent interaction are also examined as a means of theoretical evidence of the titled compound. The NBO calculations probe the intermolecular and intramolecular movement of charges, and additionally the molecule's stability. The ADMET properties are also considered for the compound with the assistance of Swiss ADMET online tool.

17p dianmotminh02 03-05-2024 1 1   Download

Ebook "Theory of sum frequency generation spectroscopy" describes fundamental theory and recent advances of sum frequency generation (SFG) spectroscopy. SFG spectroscopy is widely used as a powerful tool of surface characterization, although theoretical interpretation of the obtained spectra has been a major bottleneck for most users.

273p tracanhphuonghoa1007 22-04-2024 9 3   Download

Exosomes are promising tools for improving cancer care, but conversely may also contribute to tumor progression. Here, we highlight recently discovered roles of exosomes in modulating immune responses in cancer, with emphasis on exosomal surface proteins and on RNA and DNA content. We also discuss how exosomes could be exploited as biomarkers and delivery vehicles in cancer therapy.

4p vibransone 28-03-2024 2 2   Download

Ebook "Biogas science and technology (Advances in Biochemical engineering/biotechnology, Volume 151)" provides readers with contents including: microbiology and molecular biology tools for biogas process analysis, diagnosis and control; anaerobic fungi and their potential for biogas production; hygiene and sanitation in biogas plants;...

200p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Correlation force spectroscopy for single molecule measurements" addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to µm3) at kHz-MHz frequency range. CFS measures the simultaneous thermal fluctuations of two closely-spaced atomic force microscopy (AFM) cantilevers. CFS then calculates the cross-correlation in the thermal fluctuations that gives the mechanical properties of the matter that spans the gap of the two cantilevers.

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Ebook "Disruption of protein–protein interfaces: In search of new inhibitors" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs.

166p coduathanh1122 27-03-2024 1 1   Download

Ebook "A systems biology approach to blood" is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine.

402p cotieubac1004 15-03-2024 0 0   Download

Part 1 book "Molecular biology of drug addiction" includes content: Molecular mechanisms of opioid dependence by using knockout mice, molecular genetic approaches, different intracellular signaling systems involved in opioid tolerance dependence, inhibitors of enkephalin catabolism - new therapeutic tool in opioid dependence, recent advances in the molecular mechanisms of psychostimulant abuse using knockout mice,... and other contents.

143p muasambanhan08 04-03-2024 1 1   Download

Ebook "Annual, lunar, and tidal clocks: Patterns and mechanisms of nature’s enigmatic rhythms" aims at promoting the exciting potential of a deeper understanding of circannual, circatidal, and circalunar clocks. It highlights new developments, summarizes existing knowledge, and integrates different perspectives with the tools and ideas of diverse fields of current biology.

361p manmanthanhla0201 26-02-2024 1 1   Download

Ebook "Molecular mechanisms in yeast carbon metabolism" provides a dozen of most comprehensive reviews on the recent developments and achievements in the field of yeast carbon metabolism, from academic studies on gene expression to biotechnology relevant topics.

328p manmanthanhla0201 26-02-2024 4 1   Download

Ebook "Plant biotechnology: Experience and future prospects" updates and introduces the scope and method of plant biotechnologies and molecular breeding within the context of environmental analysis and assessment, a diminishing supply of productive arable land, scarce water resources and climate change. New plant breeding techniques including CRISPR-cas system are now tools to meet these challenges both in developed countries and in developing countries.

290p manmanthanhla0201 26-02-2024 4 1   Download

Ebook "Legumes in the Omic Era" provides a timely review of recent advances in legume genomics research and application. In this post-genomic era enormous amount of biological information is available which could be of huge potential use for crop improvement applications. This aspect of genomics assisted plant breeding is focused throughout the book for all the important grain legume crops. Role of functional genomics and importance of bioinformatics tools in present day genomics and molecular breeding research is also discussed in detail.

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Ebook "Marine toxins as research tools (Marine molecular biotechnology, Volume 46)" has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools.

268p manmanthanhla0201 26-02-2024 3 1   Download

Ebook "Static compression of energetic materials" is an introduction and review of theoretical, experimental and numerical aspects of static compression of such materials. Chapter 1 introduces the basic experimental tool, the diamond anvil pressure cell and the observational techniques used with it such as optical microscopy, infrared spectrometry and x-ray diffraction. Chapter 2 outlines the principles of high-nitrogen energetic materials synthesis. Chapters 3 and 4, examine and compare various EOS formalisms and data fitting for crystalline and non-crystalline materials, respectively....

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Part 2 book "Global food safety - Microbial interventions and molecular advancements" includes content: Foodborne pathogen detection using next generation sequencing; next generation sequencing for strain tracking and community profiling of food microbes; whole genome sequencing for food safety and quality; application of microorganism in food production and control of foodborne illness, food quality and food safety - management systems and analytical tools for public health.

155p muasambanhan07 20-02-2024 4 0   Download

Ebook "Aptamers selected by Cell-SELEX for theranostics" as the fundamental tool used to generate aptamer molecules for a wide range of applications in molecular medicine, bioanalysis and chemical biology. Easily integrated into the natural heterogeneous cell matrix, aptamers can be effectively used in theranostics, bioanalysis, environment detection and biomedical studies.

352p nhanphanguyet 28-01-2024 2 2   Download

Ebook "G protein-coupled receptors - Modeling and simulation" which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.

228p nhanphanguyet 28-01-2024 5 2   Download