Multi-component reaction

The outcomes are to be compared with typical drugs given that compounds are examined against gram-positive and gram-negative strains of bacteria and fungus. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p-position of the benzene ring, as well as products with the nitro group at the m-position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum.

8p dianmotminh02 03-05-2024 7 2   Download

The efficient synthesis of 12-substituted-3,4,4a,5,12,12a-hexahydrobenzo[b]acridine-1,6,11(2H)-triones starting from 2-amino-1,4-naphthoquinone, 1,3-cyclohexanedione, and different (hetero)aromatic aldehydes was developed. These reactions were carried out in acetic acid under microwave irradiation in the presence of p-toluenesulfonic acid as catalyst. The structure of the newly synthesized compounds were confirmed employing spectroscopic data as well as elemental analysis. The plausible mechanism of these three-component domino reactions was also described.

7p dianmotminh02 03-05-2024 4 1   Download

A simple, efficient protocol for one pot synthesis of bis(indolyl)methanes from primary alcohols is investigated with N-bromosuccinimde as a catalyst under ultrasound irradiation.

7p tocectocec 26-05-2020 14 0   Download

A Convenient and green synthesis of 4H-pyran derivatives via one-pot multicomponent reaction of aromatic aldehydes, malononitrile and ethyl acetoacetate using KOH loaded CaO as a catalyst under solvent free condition is reported. The morphology of the catalyst has been characterized by XRD and TEM.

12p tocectocec 25-05-2020 17 0   Download

Alkene monooxygenase (AMO) fromRhodococcus rhodochrous(formerly Nocardia corallina) B-276 belongs to a family of multicomponent nonheme binuclear iron-centre oxygenases that includes the soluble methane mono-oxygenases (sMMOs) found in some methane-oxidizing bacteria. The enzymes catalyse the insertion of oxygen into organic substrates (mostly hydrocarbons) at the expense of O2and NAD(P)H.

0p awards 06-04-2013 26 2   Download

Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobactersp. strain YAA. Saturation mutagen-esis of the substrate-binding pocket residues, which were identified using a homology model of theasubunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity.

12p galaxyss3 21-03-2013 34 3   Download