Multiple chronic diseases
-
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects.
16p vibransone 28-03-2024 4 1 Download
-
Multiple sclerosis is a chronic neuroinfammatory disease with a highly heterogeneous disease course. Preventing lasting disability requires early identification of persons at risk and novel approaches towards patient stratification for personalized treatment decisions. In this comment, we discuss the importance of large datasets of real-world cohorts in order to address this unmet need.
3p viellison 28-03-2024 4 2 Download
-
Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part of the pathogenesis mediating disease impact through an altered gut microbiota-brain axis.
17p vicwell 29-02-2024 2 1 Download
-
Chronic kidney disease (CKD) is highly prevalent among Indigenous Australians, especially those in remote regions. The Tiwi population has been isolated from mainland Australia for millennia and exhibits unique genetic characteristics that distinguish them from other Indigenous and non-Indigenous populations.
16p vicwell 29-02-2024 8 2 Download
-
Ebook "Studies in diabetes (Oxidative stress in applied basic research and clinical practice series)" examines how increased oxidative and nitrosative stress – one of the leading causes of diabetes complications – pathologically affects multiple tissues in the body. The volume editors and chapter authors are leading investigators in the field of basic and clinical research in diabetes and vascular disease.
277p manmanthanhla0201 26-02-2024 2 1 Download
-
Inflammatory bowel disease involves chronic inflammation and ulceration, primarily Crohn’s disease and ulcerative colitis. The prevalence of inflammatory bowel disease is rising in industrialized countries. We describe the case of a patient with inflammatory bowel disease and multiple electrolyte disturbances that emphasize the link between a vitamin D deficiency and electrolyte imbalances.
6p vitiki 30-01-2024 5 2 Download
-
Systemic lupus erythematosus (SLE) is a chronic disease that causes systemic inflammation which affects multiple organs. There is no cure for SLE. Conventional treatment options include antimalarial drugs, corticosteroids, and immune suppressants, but a number of patients are resistant to treatment or suffer from severe side effects.
6p visoros 01-11-2023 3 1 Download
-
Part 2 book "Gomella’s neonatology" includes content: ABO incompatibility, bronchopulmonary dysplasia/chronic lung disease oagulation disorders, common multiple congenital anomalies - syndromes, sequences, and associations, congenital heart disease disorders of sex development, hydrocephalus and ventriculomegaly, multiple gestation, meconium aspiration, neural tube defects, necrotizing enterocolitis,... and other contents.
641p oursky03 28-08-2023 7 1 Download
-
In this respect, a highly suspected clinical presentation should prompt the clinician to investigate the possibility of IE diagnosis. We report a case of a successful management of IE in an elderly HD patient with multiple comorbidities.
5p viwhitewolf 03-07-2023 6 2 Download
-
Multiple sclerosis is a diffuse chronic demyelinating disease of the central nervous system. It is relatively uncommon in the Asian population and even more so in males. Despite the usual involvement of the brainstem, eight-and-a-half syndrome remains a rare first presentation in multiple sclerosis.
4p videadpool 05-05-2023 3 2 Download
-
Multiple sclerosis is a chronic inflammatory, demyelinating disease of the central nervous system. Recent genome-wide studies have revealed more than 110 single nucleotide polymorphisms as associated with susceptibility to multiple sclerosis, but their functional contribution to disease development is mostly unknown.
9p vinarcissa 21-03-2023 3 1 Download
-
Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously identified a ~1.5 Mb locus on canine chromosome 27 associated with CAD in German shepherd dogs (GSDs). Fine-mapping indicated association closest to the PKP2 gene encoding plakophilin 2.
14p vinarcissa 21-03-2023 5 1 Download
-
Low serum magnesium levels have been associated with multiple chronic diseases. The regulation of serum magnesium homeostasis is not well understood. A previous genome-wide association study (GWAS) of European ancestry (EA) populations identified nine loci for serum magnesium.
9p vinarcissa 21-03-2023 5 1 Download
-
Multimorbidity is a major problem in Europe, increasing the need for prevention and rehabilitation programs. In Germany no guidelines have been developed that focus on patients with multiple chronic non-communicable diseases (NCDs). Benefits of physical activity (PA) and exercise in NCDs have been proven, but most interventions focus on single conditions.
21p viferrari 28-11-2022 8 2 Download
-
Guidelines promoting healthy lifestyles are cornerstones of chronic disease prevention and treatment. The purpose of this study is to investigate independent and joint associations of fve key health behaviors with health outcomes (body mass index (BMI kg/m2 ) and depressive symptoms) in adult twins.
15p viferrari 28-11-2022 13 2 Download
-
Chronic diseases are important risk factors of falls. However, most studies explored the effect of a single chronic disease on falls and few studies explored the combined effect of multiple chronic diseases on falls. In this study, we examined the associations between falls and multimorbidity and multimorbidity patterns.
7p viferrari 29-10-2022 6 4 Download
-
In the long-term use of multiple medications for elderly patients diagnosed with chronic diseases, medication problems are prominent, which seriously reduces their quality of life. The burden of medications of patients critically affects their medication beliefs, behaviors and disease outcomes.
9p vinobelprisen 26-03-2022 19 4 Download
-
Patients with diabetic mellitus (DM) and chronic kidney disease (CKD) are at an increased risk of urinary tract infection (UTI) due to their altered immunological integrity. These patients are similarly prone to developing frailty, a state of cumulative health deficits involving multiple domains and leading to adverse outcomes.
12p vinobelprisen 26-03-2022 13 5 Download
-
Multimorbidity is defined as the co-occurrence of multiple chronic or acute diseases and medical conditions in the same individual and can be grouped into different patterns based on the type of disease. These patterns are associated with poorer quality of life and premature death. It is believed that these patterns entail functional limitations, which may contribute to the fear of falling; however, this association remains unknown.
8p vinobelprisen 26-03-2022 16 6 Download
-
Co-existence of multiple chronic diseases is increasingly becoming a norm among ageing population. The study aims to investigate the prevalence of multimorbidity and the association between anthropometric measures of obesity and multimorbidity among men and women aged 60 years and above in India.
12p vinobelprisen 26-03-2022 15 4 Download