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Multiplex phenotyping
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The production of carbapenem enzyme is one of the most frequent mechanisms reported in cabapenem resistant Pseudomonas aeruginosa. Besides, a growing number of mobile colistin resistance (MCR) genes are threatening the renewed interest of colistin as a "last-resort" against carbapenemresistant pathogens.
5p
vikissinger
21-12-2023
1
1
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We present a method for identifying genomic modifications that optimize a complex phenotype through multiplex genome engineering and predictive modeling. We apply our method to identify six single nucleotide mutations that recover 59% of the fitness defect exhibited by the 63-codon E. coli strain C321.ΔA.
12p
vialfrednobel
29-01-2022
11
0
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Breast cancer is the most common cancer, and the leading cause of cancer-related deaths, among females world-wide. Recent research suggests that extracellular vesicles (EVs) play a major role in the development of breast cancer metastasis.
17p
vielonmusk
21-01-2022
14
0
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Improvements in asthma diagnosis and management require deeper understanding of the heterogeneity of the complex airway inflammation. We hypothesise that differences in the two major inflammatory phenotypes of asthma; eosinophilic and neutrophilic asthma, will be reflected in the lung protein expression profile of murine asthma models and can be delineated using proteomics of bronchoalveolar lavage (BAL).
12p
vimontana2711
05-04-2021
13
1
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The present study was undertaken with an objective of phenotypic and molecular detection of beta-lactam antimicrobial resistance in E. coli isolated from freshwater fish in Andhra Pradesh.
7p
gaocaolon9
22-12-2020
11
2
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Genomic, transcriptomic, and metabolic variations shape the complex adaptation landscape of bacteria to varying environmental conditions. Elucidating the genotype-phenotype relation paves the way for the prediction of such effects, but methods for characterizing the relationship between multiple environmental factors are still lacking.
13p
vioklahoma2711
19-11-2020
16
1
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A brief study was carried on forty Staphylococcus aureus isolates from Bovine milk from Ludhiana, Punjab, India for detecting the antibiotic resistance profile using E-strips and genotypically targeting various antibiotic resistance genes. The antibiotics used for phenotypic resistance detection were Penicillin, Gentamicin, Erythromycin, Clindamycin, Tetracycline, Chloramphenicol, Ciprofloxacin, Trimethoprim-sulphamethoxazole, Oxacillin, Vancomycin and Amoxyclav.
14p
nguaconbaynhay5
16-05-2020
6
0
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Present study was undertaken to assess the hygiene quality of the meat, milk and also its prevalence on human population. A total of 330 samples including, chicken meat (n=98), Chevon (n=82), raw milk samples (n=90) and human urine (n=56) and stool samples (n=4) Samples were aseptically collected from different districts of Chhattisgarh. Samples were processed for isolation of Salmonella further subjected for the different biochemical tests and confirmed by serotyping. Confirmed isolates were tested for its antibiogram pattern against 13 different antibiotic discs.
9p
kethamoi2
15-12-2019
16
0
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This study, the presence of 4 common beta-lactamase encoding genes including OXA-23, OXA-51, VIM and IMP was determined simultaneously by multiplex PCR, either directly with sputum samples or with purified DNA, giving results within 3-4 hours instead of 2 days compared to the culture method. Within 58 samples positive with Acinetobacter baumannii collected from the hospital, OXA-51 fragment was dominant (81%), whereas, VIM fragment was only identified in one sample (DNA and sputum samples) (1.7%).
4p
caygaocaolon1
13-11-2019
16
0
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Genomics and other "omics” technologies have largely contributed to the identification and the development of biomarkers. Due to genetic causes of variability among individuals, genotyping and gene expression analysis are indeed key elements of the emergence of personalised medicine. However, genomic technologies have limitations (functional significance of genetic variants, false negatives, etc) and cannot encompass all approaches for the development of stratification biomarkers.
8p
quynho77
14-11-2012
46
0
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