Neural crest cells

Ebook "Neural crest induction and differentiation" compile contributions by recognized leaders in the neural crest field who discuss all aspects of modem neural crest biology. From its evolutionary significance, to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function.

267p ladongphongthanh1008 22-04-2024 2 1   Download

Human bone marrow stromal cells (BMSCs) are an easily accessible and expandable progenitor population with the capacity to generate neural cell types in addition to mesoderm. Lineage tracing studies in transgenic animals have indicated Nestin+BMSCs to be descended from the truncal neural crest.

12p vicwell 29-02-2024 5 1   Download

Ganglioneuromas are a benign tumor originating from neural crest cells. As one of the neuroblastic tumors, ganglioneuromas are most common in children, with a mean age at presentation of 7 years. Ganglioneuro‑ mas are typically singular in nature, but rarely can present with lymph node involvement and distant metastasis.

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Ebook "Current topics in developmental biology (Volume 1)" provides both a unique perspective and a much needed resource. Work in zebrafish disease models has expanded beyond genetic disorders and developmental defects, and there is now an active and growing community of researchers studying a range of diseases in zebrafish.

373p lucchinguyen 28-12-2023 4 2   Download

Waardenburg syndrome is a genetic disorder, resulting in defective control of the division and migration of neural crest cells including the melanocyte lineage during embryonic development. Primary involvement of melanocytes results in the characteristic phenotypic involvement including a white forelock, vitiligo, and heterochromia.

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Part 1 book "Avian embryology" includes content: Operations on primitive streak stage avian embryos; quail–chick transplantations, other chimeras - quail–duck and mouse–chick; manipulations of neural crest cells or their migratory pathways; embryo slices and strips - guidance and adhesion assays in the avian embryo; embryo slices and strips - guidance and adhesion assays in the avian embryo; cell division, diverentiation, and death in avian embryos;.... and other contents.

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The evolutionarily conserved Sonic Hedgehog (Shh) signaling pathway is essential for embryogenesis and orofacial development. SHH ligand secreted from the surface ectoderm activates pathway activity in the underlying cranial neural crest cell (cNCC)-derived mesenchyme of the developing upper lip and palate. Disruption of Shh signaling causes orofacial clefts, but the biological action of Shh signaling and the full set of Shh target genes that mediate normal and abnormal orofacial morphogenesis have not been described.

11p vibeauty 23-10-2021 18 1   Download

The neural crest (NC) is a class of transitory stem cell-like cells unique to vertebrate embryos. NC cells arise within the dorsal neural tube where they undergo an epithelial to mesenchymal transition in order to migrate and differentiate throughout the developing embryo. The derivative cell types give rise to multiple tissues, including the craniofacial skeleton, peripheral nervous system and skin pigment cells.

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Human dental pulp represents a suitable alternative source of stem cells for the purpose of cell-based therapies in regenerative medicine, because it is relatively easy to obtain it, using low invasive procedures. This study characterized and compared two subpopulations of adult stem cells derived from human dental pulp (hDPSCs).

16p viwyoming2711 16-12-2020 9 1   Download

Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of origin along the antero-posterior axis cranial NCCs are rapidly sorted into distinct migratory streams that give rise to axial specific structures.

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Small-cell lung cancer (SCLC) is known to express antigens of both the neural crest and epithelium, and to secrete polypeptide hormones and enzymes. Anecdotal reports correlate lung cancer with marked hyperamylasemia, and a review of the literature reveals only one case of metastatic SCLC linked to high paraneoplastic lipase production.

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Neuroblastoma is a pediatric cancer with a low survival rate of patients with metastatic stage 4 disease. Tumor aggressiveness and progression have been associated with structural copy number variations (CNVs) that are observed in malignant cells. In contrast, localized Neuroblastomas, which are associated with a low number of structural CNVs but frequent numerical CNVs, are less aggressive, and patients have good outcomes.

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Neuroblastoma (NB), a tumor of the primitive neural crest, despite aggressive treatment portends a poor long-term survival for patients with advanced high stage NB. New treatment strategies are required.

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Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for tumour progression, chemotherapy resistance and recurrence in NBTs.

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Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. New therapeutic approaches for both NF1 and NF2 are badly needed.

13p vimax2711 27-03-2020 10 0   Download

Idiopathic scoliosis is one of the most common disabling pathologies of children and adolescents. Etiology and pathogenesis of idiopathic scoliosis remain unknown. To study the etiology of this disease we identified the cells’ phenotypes in the vertebral body growth plates in patients with idiopathic scoliosis

11p vinasaki2711 12-11-2019 9 1   Download

HAND2/dHAND is a basic helix-loop-helix transcription factor expressed in the heart and neural crest derivatives during embryogenesis. Although dHAND is essential for branchial arch, cardiovascular and limb development, its target genes have not been identified. The regulatory mech-anisms of dHAND function also remain relatively unknown. Here we report that Akt/PKB, a serine/threonine protein kinase involved in cell survival, growth and differ-entiation, phosphorylates dHAND and inhibits dHAND-mediated transcription....

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Familiarity with lacrimal system embryology is necessary to understand congenital abnormalities of the nasolacrimal drainage system. The orbital walls are embryologically derived from neural crest cells. Ossifi cation of the orbital walls is completed by birth except at the orbital apex. The lesser wing of the sphenoid is initially cartilaginous, unlike the greater wing of the sphenoid and other orbital bones that develop via intramembranous ossifi cation.

292p taurus23 26-09-2012 83 7   Download

In Chapter 5, Carrascosa Romero and de Cabo de la Vega consider the relevance of genetics and brain imaging findings in the diagnosis of diseases which result from abnormal development or neoplasia of cells derived from the neural crest (neurocristopathies). Koga and Saito (Chapter 6) provide a beautifully illustrated discussion of the use of neuroimaging tools to guide gamma knife radiosurgery.

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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Compound developmental eye disorders following inactivation of TGF signaling in neural-crest stem cells...

16p toshiba3 07-09-2011 40 3   Download