Neural crest origin

Human bone marrow stromal cells (BMSCs) are an easily accessible and expandable progenitor population with the capacity to generate neural cell types in addition to mesoderm. Lineage tracing studies in transgenic animals have indicated Nestin+BMSCs to be descended from the truncal neural crest.

12p vicwell 29-02-2024 5 1   Download

Ganglioneuromas are a benign tumor originating from neural crest cells. As one of the neuroblastic tumors, ganglioneuromas are most common in children, with a mean age at presentation of 7 years. Ganglioneuro‑ mas are typically singular in nature, but rarely can present with lymph node involvement and distant metastasis.

5p vilazada 31-01-2024 4 2   Download

Cranial neural crest cells (NCCs) are a unique embryonic cell type which give rise to a diverse array of derivatives extending from neurons and glia through to bone and cartilage. Depending on their point of origin along the antero-posterior axis cranial NCCs are rapidly sorted into distinct migratory streams that give rise to axial specific structures.

12p viwyoming2711 16-12-2020 7 1   Download

Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. New therapeutic approaches for both NF1 and NF2 are badly needed.

13p vimax2711 27-03-2020 10 0   Download

Melanotic neuroectodermal tumour of infancy (MNTI) is a rare, pigmented neoplasm neural crest origin. The mean age of patients at diagnosis is 4.3 months, with a near-equal male to female ratio of 6:7.

6p vistockholm2711 13-12-2019 17 1   Download