Neurological disorders

Migraine is a common disorder; however, it is still not perfectly diagnosed and treated due to many difficulties in recognizing symptoms or accompanying risk factors. Understanding migraine headaches through surveying standard samples can guide clinicians in the appropriate way of diagnosis and treatment.

6p vinara 11-01-2025 1 0   Download

The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.

234p runthenight04 02-02-2023 11 3   Download

Neurodegenerative disorders, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases, affect millions of people worldwide and currently there are few effective treatments and no cures for these diseases. Transgenic mice expressing human transgenes for huntingtin, amyloid precursor protein, and other genes associated with familial forms of neurodegenerative disease in humans provide remarkable tools for studying neurodegeneration because they mimic many of the pathological and behavioural features of the human conditions. ...

15p awards 06-04-2013 39 4   Download

The GM2-activator protein (GM2AP) is an essential cofactor for the degradation of ganglioside GM2 by lyso-somal b-hexosaminidase A. It mediates the interaction between the water-soluble exohydrolase and its membrane-bound substrate at the lipid–water interphase. Inherited defects in the gene encoding this glycoprotein result ina fatal neurological storage disorder, the AB variant of GM2-gangliosidosis. To elucidate the mode of action of this gly-coprotein cofactor, we synthesized the two photoaffinity labels [ 14 C]C3 -TPD-GM2 and [ 14 C]C7 -TPD-GM2. ...

14p dell39 03-04-2013 62 4   Download

The GM2-activator protein (GM2AP) is an essential cofactor for the lyso-somal degradation of ganglioside GM2 by b-hexosaminidase A (HexA). It mediates the interaction between the water-soluble exohydrolase and its membrane-embedded glycolipid substrate at the lipid–water interface. Functional deficiencies in this protein result in a fatal neurological storage disorder, the AB variant of GM2 gangliosidosis.

10p inspiron33 26-03-2013 53 4   Download

Gaucher disease is an autosomal recessive lysosomal storage disorder caused by the deficient activity of glucocerebrosidase. Accumulation of glucosylceramide, primarily in the lysosomes of cells of the reticuloendo-thelial system, leads to hepatosplenomegaly, anemia and skeletal lesions in type I disease, and neurologic manifestations in types II and III disease.

11p inspiron33 25-03-2013 52 4   Download

Human glutamate carboxypeptidase II [GCPII (EC 3.4.17.21)] is recog-nized as a promising pharmacological target for the treatment and imaging of various pathologies, including neurological disorders and prostate can-cer. Recently reported crystal structures of GCPII provide structural insight into the organization of the substrate binding cavity and highlight residues implicated in substrate⁄inhibitor binding in the S1¢ site of the enzyme.

11p media19 04-03-2013 43 4   Download

Alzheimer’s disease (AD) is a neurological disorder characterized by the presence of amyloidb(Ab) peptide fibrils and oligomers in the brain. It has been suggested that soluble Ab oligomers, rather than Ab fibrils, contribute to neurodegeneration and dementia due to their higher level of toxicity.

12p vinaphone15 28-02-2013 34 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)

5p panasonic01 13-12-2011 46 5   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Upper limb impairments associated with spasticity in neurological disorders

15p panasonic01 12-12-2011 68 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: WHO global campaigns: A way forward in addressing public health importance of common neurological disorders...

2p thulanh10 09-10-2011 48 4   Download